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Bicalutamide

Latest prescription information about Bicalutamide. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Bicalutamide
Pronunciation : bye ka LOO ta mide
Trade Name(s): 
India- Biprosta Tab, Caludec Tab, Caluran Tab, Calutide-50 Film-Coated Tab, Casodex Tab, Cosalon Tab, Utamide Tab.
International- Casodex.
Why it is prescribed (Indications) : 
This medication is a non-steroidal anti-androgen, prescribed for prostate cancer.  It blocks testosterone action.
When it is not to be taken (Contraindications): 
Contraindicated in women, lactation, pregnancy; hypersensitivity.

Pregnancy Category :

A B C D X
Category X : Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.

Dosage & When it is to be taken : 
Adult: PO- 50 mg (1 tablet) once daily at the same time of day with or without food.
How it should be taken : 
It comes as a tablet to take by mouth, with or without food.
Warnings and Precautions : 
* Monitor liver function regularly.
* Monitor serum level of prostate specific antigen (PSA) regularly, to evaluate patient's clinical progress.
* It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.
Side Effects : 
Body as a Whole- Pain (general), back pain, weakness, pelvic pain, infection, abdominal pain, chest pain headache, flu like syndrome, fever and chills.
Heart- Hot flashes, high blood pressure, chest pain and congestive heart failure.
Gastrointestinal- Constipation, nausea, diarrhea, increased liver enzyme, indigestion, flatulence, loss of appetite, vomiting, blood in stool, dry mouth, difficulty in swallowing and gastrointestinal disorder.
Blood- Anemia.
Metabolic- Swelling in the extremities, weight loss, increased blood sugar level, weight gain, blood urea nitrogen and dehydration.
Musculoskeletal - Muscle/joint pain, leg cramps and fractures.
Central Nervous System- Dizziness, drowsiness, tingling, sleeplessness, anxiety, confusion, decreased libido, nervousness and depression.
Respiratory - Difficulty in breathing, increased cough, inflammation of pharynx/bronchus/nose/sinus, asthma and nosebleed.
Skin - Rash, sweating, dry skin, hair loss, itching and skin cancer.
Genitourinary- Blood in urine, urinary tract infection, breast enlargement in male, impotence, painful urination, breast pain, increased urinary frequency, urinary retention and urinary incontinence.
Other Precautions : 
* Limit the intake of alcoholic beverages.
Storage Conditions : 
Oral: Store it at controlled room temperature (30°C).

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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