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Benazepril HCl and Hydrochlorothiazide

Updated on : September - 2012
Latest prescription information about Benazepril HCl and Hydrochlorothiazide. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Benazepril HCl and Hydrochlorothiazide
Pronunciation : ben-AZ-e-pril - HYE-droe-KLOR-oh-THYE-a-zide
Trade Name(s): 
International- Lotensin HCT.
Why it is prescribed (Indications) : This combination medication contains angiotensin-converting enzyme (ACE) inhibitor and thiazide diuretic, prescribed for high blood pressure. It helps the kidney to get rid of unneeded water and salt from the body into the urine.
When it is not to be taken (Contraindications): Contraindicated in patients with anuria (unable to urinate) or hypersensitivity.

Pregnancy Category :

A B C D X
Category D : There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : The usual recommended initial dose is 10/12.5 mg once daily. The maximum recommended dose is 20mg/25mg.
How it should be taken : It comes as a tablet to take by mouth, with or without food.
Warnings and Precautions : 
* Caution should be exercised in patients with history of heart, liver or kidney disease, aortic stenosis, blood vessel problems, bone marrow problems, high cholesterol or lipid levels, diabetes, gout, stroke, recent heart attack, kidney transplant, autoimmune disease, dehydration, low blood pressure, who are taking other medications, any allergy, elderly, children, during pregnancy and breast feeding.
* It may cause dizziness, light-headedness, or fainting, do not drive a car or operate machinery and sit up or stand slowly while taking this medication.
* Patient may develop with increased risk of certain eye problems; if it is so consult with your doctor immediately.
* It may lead to dehydration; drink adequate fluid.
* Avoid exposure to sunlight.
* Monitor blood electrolytes, blood pressure, complete blood cell counts, liver function, and kidney function regularly while taking this medication.
Side Effects : 
Cough, dizziness, headache, and fatigue.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Do not store above (30°C). Protect from moisture and light.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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