Azithromycin - Drug InformationGeneric Name : Azithromycin | Pronunciation : ay-ZITH-roe-MYE-sin
Why it is prescribed (Indications) :
This medication is a macrolide antibiotic used for various bacterial infections such as infections of the middle ear, throat, bronchus, sinuses, skin and soft tissue. It is also useful in treating pneumonia, typhoid, gonorrhoea, granuloma inguinale and chancroid. It prevents bacterial growth.
When it is not to be taken (Contraindications):
Pregnancy Category :
Category B :Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.
Dosage & When it is to be taken :
Adult: PO- Respiratory tract, Skin and soft tissue infections- 500 mg once daily for 3 days. Or 500mg on day 1 followed by 250mg on days 2 to 5.
Typhoid- 500 mg once daily for 7 days.
Uncomplicated gonorrhoea- 2 g single dose.
Granuloma inguinale- Initial: 1 g, then 500 mg/day until all lesions has healed completely.
Chancroid/Chlamydial urethritis: 1 g single dose Prophylaxis of disseminated MAC infections 1.2 g once weekly. Treatment or secondary prophylaxis: administered along with other antimycobacterials: 500 mg once daily.
How it should be taken :
It comes as a tablet and liquid to take by mouth, with or without food.
Warnings and Precautions :Caution should be exercised in patients with history of cystic fibrosis, human immunodeficiency virus (HIV), irregular heartbeat, or kidney or liver disease, during pregnancy and breastfeeding.
Side Effects :
Heart- Chest pain, abnormal heart rate, low blood pressure, abnormal heart rhythm with QT prolongation and torsades de pointes.
Gastrointestinal- Indigestion, loss of appetite, flatulence, gastritis, loose stools, vomiting, colitis and constipation.
Genitourinary- Kidney failure and vaginal inflammation.
Blood- Decrease in platelets.
Liver- Abnormal liver function, jaundice and liver failure.
Central Nervous System- Weakness, tingling, fatigue, uneasiness, dizziness/vertigo, headache, drowsiness, hyperactivity, nervousness, agitation and syncope.
Skin- Itching, severe allergic reactions, irritation, fungal infection, sweating, hives and blistering.
ENT- Hearing loss and/or tinnitus, abnormalities in taste and smell sensation.
Hypersensitivity - Allergic reaction.
Respiratory- Increased cough, inflammation of pharynx, pleural effusion and rhinitis.