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Generic Name : Azacitidine
Pronunciation : ay-za-SYE-ti-deen
Trade Name(s):
International- Vidaza. This medication is an antineoplastic agent, prescribed for blood cancer. When it is not to be taken (Contraindications):
When it is to be taken : SC/IV- First Treatment Cycle: The recommended starting dose is 75 mg/m2, daily for 7 days. Subsequent Treatment Cycles: Cycles should be repeated every 4 weeks. The dose may be increased to 100 mg/m2. How it should be taken : It comes as a solution for injection to be administered by a healthcare provider into the vein or large muscle. Special Instruction : * Caution should be exercised in patients with history of kidney or liver problems, any allergy, who are taking other medication, elderly, children, during pregnancy and breastfeeding. * It may cause dizziness, fainting, or lightheadedness, do not drive a car or operate machinery and get up slowly from bed while taking this medication. * It may reduce platelet counts; avoid injury or bruising. * Monitor liver, kidney functions, and blood cell counts regularly while taking this medication. * Avoid contact with people who have infections. Side Effects : Most Common - Nausea, anemia, decrease in blood cells, vomiting, pyrexia, diarrhea, injection site redness, constipation and skin discoloration. Blood- Anemia. Gastrointestinal - Abdominal tenderness, constipation, diarrhea, gum bleeding, loose stools, bleeding of mouth, nausea, vomiting and mouth ulcer. General - Chest pain, injection site bruising, redness, pain, pigmentation, itching, swelling; lethargy, uneasiness and fever. Infections - Pneumonia and upper respiratory tract infection. Metabolic - Loss of appetite. Musculoskeletal - Joint pain, chest wall pain and muscle pain. Central Nervous system - Dizziness, headache, anxiety and sleeplessness. Respiratory - Difficulty in breathing. Skin - Dry skin, discoloration, redness, rash, scar and hives. Heart - Blood clot, low blood pressure, and red spots. * Avoid excess dosage. Storage Conditions : Store unreconstituted vials at room temperature (25ºC). |
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