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Atropine and diphenoxylate

Latest prescription information about Atropine and diphenoxylate. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Atropine and diphenoxylate
Pronunciation : a' troe peen - dye fen ox' i late
Therapeutic Classification : Anticholinergics
ICD Code : Y51.3
Trade Name(s): 
India- Lomotil.
International- Di-Atro , Dimotal , Lomocot , Lomotil , Lomotil Solution , Lonox , Vi-Atro.
Why it is prescribed (Indications) : 
This medication is an antidiarrheal and anticholinergic combination, prescribed for diarrhea. Atropine works by reducing spasms where as Diphenoxylate decreases bowel movement.
When it is not to be taken (Contraindications): 
Contraindicated in patients with obstructive jaundice, pseudomembranous enterocolitis and hypersensitivity.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
In adults, the usual dose is 5 mg (2 tablets) three to four times per day initially. The dose for children is based on weight.
How it should be taken : 
It comes as a tablet to take by mouth, with or without food.
Warnings and Precautions : 
* Caution should be exercised in patients with history of lung disease, ulcerative colitis, or liver disease, alcohol abuse, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.
* It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.
* Avoid alcohol consumption.
* Avoid hot weather; otherwise it may cause heatstroke.
* It may cause fluid or electrolyte disturbances; if it so consult with your doctor.
Side Effects : 
Central Nervous system - Numbness, emotional state, depression, tiredness, confusion, drowsiness, dizziness, restlessness and headache.
Allergic - Hives, rashes, itching and swelling of the gums.
Gastrointestinal - Intestinal toxicity, intestinal obstruction, inflammation of pancreas, vomiting, nausea, loss of appetite and abdominal discomfort.
Other Precautions : 
* Avoid excess dosage.
* It may cause photosensitivity, wear sunglasses while going out.
Storage Conditions : 
Store it at room temperature (25o C), and in an airtight container, keep away from children.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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