Atropine and diphenoxylate - Drug Information

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General Information on Atropine and diphenoxylate

Generic Name : Atropine and diphenoxylate

Pronunciation : a' troe peen - dye fen ox' i late

Latest prescription information about Atropine and diphenoxylate. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y51.3 | Therapeutic Classification : Anticholinergics

Trade Names/Brand Names of Atropine and diphenoxylate

India : 

International : 

Di-Atro , Dimotal , Lomocot , Lomotil , Lomotil Solution , Lonox , Vi-Atro

Why is Atropine and diphenoxylate Prescribed? (Indications)

This medication is an antidiarrheal and anticholinergic combination, prescribed for diarrhea. Atropine works by reducing spasms where as Diphenoxylate decreases bowel movement.

When should Atropine and diphenoxylate not to be taken? (Contraindications)

Contraindicated in patients with obstructive jaundice, pseudomembranous enterocolitis and hypersensitivity.

Pregnancy Category

A B C D X

Category C :

Animal studies have shown adverse effects on the fetus and there are no appropriate studies in pregnant women, but potential benefits may allow the use of the drug in pregnant women despite the potential for risks.

What is the dosage of Atropine and diphenoxylate?

In adults, the usual dose is 5 mg (2 tablets) three to four times per day initially. The dose for children is based on weight.

How should Atropine and diphenoxylate be taken?

It comes as a tablet to take by mouth, with or without food.

What are the warnings and precautions for Atropine and diphenoxylate?

Caution should be exercised in patients with history of lung disease, ulcerative colitis, or liver disease, alcohol abuse, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.
It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.
Avoid alcohol consumption.
Avoid hot weather; otherwise it may cause heatstroke.
It may cause fluid or electrolyte disturbances; if it so consult with your doctor.

What are the side effects of Atropine and diphenoxylate?

   Central Nervous system : Numbness, emotional state, depression, tiredness, confusion, drowsiness, dizziness, restlessness and headache.
   Allergic : Hives, rashes, itching and swelling of the gums.
   Gastrointestinal : Intestinal toxicity, intestinal obstruction, inflammation of pancreas, vomiting, nausea, loss of appetite and abdominal discomfort.

What are the other precautions for Atropine and diphenoxylate?

Avoid excess dosage.
It may cause photosensitivity, wear sunglasses while going out.

What are the storage conditions of Atropine and diphenoxylate?

Store it at room temperature (25o C), and in an airtight container, keep away from children.

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