This medication is an antidiarrheal and anticholinergic combination, prescribed for diarrhea. Atropine works by reducing spasms where as Diphenoxylate decreases bowel movement.
Contraindicated in patients with obstructive jaundice, pseudomembranous enterocolitis and hypersensitivity.
In adults, the usual dose is 5 mg (2 tablets) three to four times per day initially. The dose for children is based on weight.
It comes as a tablet to take by mouth, with or without food.
• Caution should be exercised in patients with history of lung disease, ulcerative colitis, or liver disease, alcohol abuse, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.
• It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.
• Avoid alcohol consumption.
• Avoid hot weather; otherwise it may cause heatstroke.
• It may cause fluid or electrolyte disturbances; if it so consult with your doctor.
• Central Nervous system :
Numbness, emotional state, depression, tiredness, confusion, drowsiness, dizziness, restlessness and headache.
• Allergic : Hives, rashes, itching and swelling of the gums.
• Gastrointestinal : Intestinal toxicity, intestinal obstruction, inflammation of pancreas, vomiting, nausea, loss of appetite and abdominal discomfort.
Avoid excess dosage.
It may cause photosensitivity, wear sunglasses while going out.
Store it at room temperature (25o C), and in an airtight container, keep away from children.
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