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Articane HCl and Epinephrine Injection

Latest prescription information about Articane HCl and Epinephrine Injection. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Articane HCl and Epinephrine Injection
Pronunciation : AR ti kane and EP i NEF rin
Therapeutic Classification : Local Anesthetics
Trade Name(s): 
International- Septocaine.
Why it is prescribed (Indications) : 
This medication is a local dental anesthetic, used as an anesthesia for dental procedures. 
When it is not to be taken (Contraindications): 
Hypersensitivity.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
The recommended dose is 7 mg/kg (0.175 mL/kg).
How it should be taken : 
It comes as a solution for injection, to be administered by a healthcare provider either via submucosal infiltration or nerve block.
Warnings and Precautions : 
* Caution should be exercised in patients with history of low or high blood pressure, asthma, seizures, any allergy, during pregnancy and breastfeeding.
Side Effects : 
Body as a Whole - Weakness, back pain, injection site pain, burning sensation above injection site, uneasiness and neck pain.
Heart - Bleeding, migraine, fainting, fast heart rate and elevated blood pressure.
Gastrointestinal - Indigestion, tongue inflammation, gum bleeding, mouth ulceration, nausea, tongue swelling, tooth disorder and vomiting.
Blood and Lymphatic - Bruising, swelling of lymph nodes.
Metabolic - Fluid retention and increased thirst.
Musculoskeletal - Joint pain, muscle pain, and chronic bone infection.
Central Nervous System - Dizziness, dry mouth, facial paralysis, abnormal increase in sensitivity, increased salivation, nervousness, nerve disease, tingling, drowsiness, exacerbation of Kearns-Sayre Syndrome.
Respiratory - Inflammation of pharynx, runny nose and sinus pain.
Skin - Itching and skin disorder.
Eye and ENT - Ear pain and taste perversion.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it at controlled room temperature (25°C).

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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