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Generic Name : Aprotinin
Pronunciation : a-proe-TYE-nin
Therapeutic Classification : Hemostatic Agents
Trade Name(s): India- Aprogen Inj, Apronin Vial, Aprostat Vial, Aprotec Vial, Aprotin Vial, Haemaprot Inj, Haemoprot Vial, Kallistat Vial. International- Emend,Trasylol. International-Trasylol. Why it is prescribed (Indications) : This medication is a protease inhibitor, prescribed for reducing blood loss and the need for blood transfusion in patients undergoing cardiopulmonary bypass surgery. When it is not to be taken (Contraindications): Hypersensitivity.
Dosage & When it is to be taken : The 1ml initial (test) dose should be administered intravenously at least 10 minutes before the loading dose. Adult: IV- 5 lac KIU (Kallikrein in activator unit) initially, followed by 2 lac KIU every 4 hour. How it should be taken : It comes as a solution for injection, to be administered by a healthcare provider into the vein. Warnings and Precautions : * Test dose is recommended to all patients to assess the risk of hypersensitivity. * Caution should be exercised in patients with history of heart surgery, liver or kidney disease, allergy, during pregnancy and lactation. * Patient may develop with increased risk of severe allergic reactions if it is administered within 12 months of previous use of this medication. Side Effects : Body as a Whole- Fever, infection, chest pain and weakness. Heart- Low blood pressure, fast heart rate, heart attack and heart failure. Gastrointestinal- Nausea, constipation, vomiting and diarrhea. Blood- Anemia. Metabolic- Increased liver enzyme level. Musculoskeletal- Any event. Central Nervous System- Confusion and sleeplessness. Respiratory- Lung disorder, pleural effusion, difficulty in breathing, asthma and shortness of breath. Skin- Rash. Genitourinary- Abnormal kidney function, urinary retention and urinary tract infection. Potentially Fatal-: Fatal anaphylactic reactions. * It should not be used in neonates and children. Storage Conditions : Intravenous: Store at 2-25°C. |
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