Generic Name : Aprotinin Pronunciation : a-proe-TYE-nin Therapeutic Classification : Hemostatic Agents
India- Aprogen Inj, Apronin Vial, Aprostat Vial, Aprotec Vial, Aprotin Vial, Haemaprot Inj, Haemoprot Vial, Kallistat Vial.
International-Trasylol. Why it is prescribed (Indications) :
This medication is a protease inhibitor, prescribed for reducing blood loss and the need for blood transfusion in patients undergoing cardiopulmonary bypass surgery. When it is not to be taken (Contraindications):
Dosage & When it is to be taken :
The 1ml initial (test) dose should be administered intravenously at least 10 minutes before the loading dose.
Adult: IV- 5 lac KIU (Kallikrein in activator unit) initially, followed by 2 lac KIU every 4 hour. How it should be taken :
It comes as a solution for injection, to be administered by a healthcare provider into the vein. Warnings and Precautions :
* Test dose is recommended to all patients to assess the risk of hypersensitivity.
* Caution should be exercised in patients with history of heart surgery, liver or kidney disease, allergy, during pregnancy and lactation.
* Patient may develop with increased risk of severe allergic reactions if it is administered within 12 months of previous use of this medication.
Side Effects :
Body as a Whole- Fever, infection, chest pain and weakness.
Heart- Low blood pressure, fast heart rate, heart attack and heart failure.
Gastrointestinal- Nausea, constipation, vomiting and diarrhea.
Metabolic- Increased liver enzyme level.
Musculoskeletal- Any event.
Central Nervous System- Confusion and sleeplessness.
Respiratory- Lung disorder, pleural effusion, difficulty in breathing, asthma and shortness of breath.
Genitourinary- Abnormal kidney function, urinary retention and urinary tract infection.
Potentially Fatal-: Fatal anaphylactic reactions.
* It should not be used in neonates and children.
Storage Conditions :
Intravenous: Store at 2-25°C.
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