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Aprotinin

Latest prescription information about Aprotinin. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Aprotinin
Pronunciation : a-proe-TYE-nin
Therapeutic Classification : Hemostatic Agents
Trade Name(s): 
India- Aprogen Inj, Apronin Vial, Aprostat Vial, Aprotec Vial, Aprotin Vial, Haemaprot Inj, Haemoprot Vial, Kallistat Vial.
International- Emend,Trasylol.
International-Trasylol.
Why it is prescribed (Indications) : 
This medication is a protease inhibitor, prescribed for reducing blood loss and the need for blood transfusion in patients undergoing cardiopulmonary bypass surgery.  
When it is not to be taken (Contraindications): 
Hypersensitivity.

Pregnancy Category :

A B C D X
Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Dosage & When it is to be taken : 
The 1ml initial (test) dose should be administered intravenously at least 10 minutes before the loading dose.
Adult: IV- 5 lac KIU (Kallikrein in activator unit) initially, followed by 2 lac KIU every 4 hour.
How it should be taken : 
It comes as a solution for injection, to be administered by a healthcare provider into the vein.
Warnings and Precautions : 
* Test dose is recommended to all patients to assess the risk of hypersensitivity.
* Caution should be exercised in patients with history of heart surgery, liver or kidney disease, allergy, during pregnancy and lactation.
* Patient may develop with increased risk of severe allergic reactions if it is administered within 12 months of previous use of this medication.
Side Effects : 
Body as a Whole- Fever, infection, chest pain and weakness.
Heart- Low blood pressure, fast heart rate, heart attack and heart failure.
Gastrointestinal- Nausea, constipation, vomiting and diarrhea.
Blood- Anemia.
Metabolic- Increased liver enzyme level.
Musculoskeletal- Any event.
Central Nervous System- Confusion and sleeplessness.
Respiratory- Lung disorder, pleural effusion, difficulty in breathing, asthma and shortness of breath.
Skin- Rash.
Genitourinary- Abnormal kidney function, urinary retention and urinary tract infection.
Potentially Fatal-: Fatal anaphylactic reactions.
Other Precautions : 
* It should not be used in neonates and children.
Storage Conditions : 
Intravenous: Store at 2-25°C.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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