Generic Name : Aprepitant Pronunciation : ap-RE-pi-tant Therapeutic Classification : Antiemetics ICD Code : Y43.0
India- Aprecap, Aprelief, Apretero, Empov.
International- Emend. Why it is prescribed (Indications) :
This medication is an antiemetic, prescribed for prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) and for prevention of postoperative nausea and vomiting. When it is not to be taken (Contraindications):
Contraindicated in patients who are taking astemizole, cisapride, pimozide, or terfenadine and hypersensitivity.
Dosage & When it is to be taken :
PO- The recommended dose is 125 mg, 1 hour prior to chemotherapy treatment (Day 1) and 80 mg orally once daily in the morning on Days 2 and 3. How it should be taken :
It comes as a capsule to take by mouth, with or without food. Warnings and Precautions :
* Caution should be exercised in patients with history of nausea or vomiting, liver disease, any allergy, who are taking other medications, during pregnancy and breastfeeding.
* It may cause dizziness, do not drive a car or operate machinery while taking this medication.
* Avoid alcohol consumption. Side Effects :
Body as a Whole - Weakness/fatigue, dizziness, dehydration, abdominal pain and fever.
Gastrointestinal - Nausea, constipation, diarrhea, vomiting, heartburn and stomach discomfort.
ENT - Ringing in the ear.
Blood - Decrease in white blood cells.
Metabolic - Loss of appetite.
Central Nervous System - Headache and sleeplessness.
Respiratory - Hiccups.
* Avoid excess dosage. Storage Conditions :
Store it at room temperature (20-25°C).
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