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Medindia » Medication Manual » Aprepitant

Aprepitant

Latest prescription information about Aprepitant. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.

Generic Name : Aprepitant

Pronunciation : ap-RE-pi-tant

Therapeutic Classification : Antiemetics

ICD Code : Y43.0

Trade Name(s):
India- Aprecap, Aprelief, Apretero, Empov.
International- Emend.

Why it is prescribed (Indications) :
This medication is an antiemetic, prescribed for prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) and for prevention of postoperative nausea and vomiting.

When it is not to be taken (Contraindications):
Contraindicated in patients who are taking astemizole, cisapride, pimozide, or terfenadine and hypersensitivity.

Pregnancy Category :

A B C D X

Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Dosage & When it is to be taken :
PO- The recommended dose is 125 mg, 1 hour prior to chemotherapy treatment (Day 1) and 80 mg orally once daily in the morning on Days 2 and 3.

How it should be taken :
It comes as a capsule to take by mouth, with or without food.

Warnings and Precautions :
* Caution should be exercised in patients with history of nausea or vomiting, liver disease, any allergy, who are taking other medications, during pregnancy and breastfeeding.
* It may cause dizziness, do not drive a car or operate machinery while taking this medication.
* Avoid alcohol consumption.

Side Effects :
Body as a Whole - Weakness/fatigue, dizziness, dehydration, abdominal pain and fever.
Gastrointestinal - Nausea, constipation, diarrhea, vomiting, heartburn and stomach discomfort.
ENT - Ringing in the ear.
Blood - Decrease in white blood cells.
Metabolic - Loss of appetite.
Central Nervous System - Headache and sleeplessness.
Respiratory - Hiccups.

Other Precautions :
* Avoid excess dosage.

Storage Conditions :
Store it at room temperature (20-25°C).