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Anastrozole

Latest prescription information about Anastrozole. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Anastrozole
Pronunciation : an as' troe zole
Therapeutic Classification : antiestrogens
Trade Name(s): 
India- Altraz Tab, Altrol Tab, Anabrez Tab, Arimidex Tab, Armotraz Tab, Redest Tab, Stazonex Tab.
International-Arimidex.
Why it is prescribed (Indications) : 
This medication is prescribed for early breast cancer in women who have experienced menopause including women with disease progression after tamoxifen therapy. It is a non-steroidal aromatase inhibitor. It decreases the amount of estrogen the body makes.

When it is not to be taken (Contraindications): 


Contraindicated to pregnancy, premenopausal women, patients who are experienced with hypersensitivity to any components.

Pregnancy Category :

A B C D X
Category D : There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.


When it is to be taken : 
Adjuvant treatment in early breast cancer; Advanced or locally advanced breast cancer in postmenopausal women: 1 mg/day.
How it should be taken : 
This medication available in the form of tablets to take by mouth once a day, with or without food.
Special Instruction : 
*Caution should be exercised in patients with history of moderate or severe liver impairment, excess fat.
*It may cause dizziness. Do not drive a car or operate machinery while driving this medication.
* Avoid alcohol consumption.
*Do the lab test for menopause if status is doubtful.
*Bone mass density (bone mineral density) test should be conducted at the start of the therapy and at regular intervals thereafter.
Side Effects : 
Heart- Widening of blood vessels, hypertension, sudden cardiac death, blood clot in veins and insufficient blood supply to brain.
Central Nervous System- Lack of energy, mood disturbances, headache, depression, sleeplessness, dizziness, abnormal sensations, anxiety, increased tightness of muscle and fatigue.
Skin- Rash, sweating, redness of the skin, mucous membrane infection.
Eye and ENT- Inflammation of pharynx and clouding of eye lenses.
Gastrointestinal- Stomach disturbances, nausea, vomiting, abdominal pain, constipation, diarrhea, loss of appetite, indigestion, gastrointestinal disorder and dry mouth.
Genitourinary- Breast pain, urinary tract infection, inflammation of vagina, breast neoplasm, vaginal bleeding, whitish or yellowish vaginal discharge and vaginal dryness.
Blood-Lymphatic- Lymph nodes swelling, decrease in hemoglobin, and white blood cells.
Liver- Increased level of liver enzymes and jaundice.
Hypersensitivity- Allergic reactions including hypersensitivity reaction, rapid swelling of the dermis and skin rash.
Metabolic-Nutritional- Edema, high blood cholesterol and weight gain.
Musculoskeletal- Inflammation of joints, joint pain, back pain, bone pain, an increased risk of fracture, pelvic pain and muscle pain.
Respiratory-Difficulty in breathing, increased cough, sinus or sinusitis and inflammation of bronchus.
Miscellaneous- Hot flashes, pain, accidental injury, infection, chest pain, flu syndrome, cyst, neoplasm and tumor flare.
Other Precautions : 
* Monitor cholesterol levels and bone mineral density periodically.
Storage Conditions : 
Oral: Store at 20-25�C. Store it in airtight container.

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