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Generic Name : Anastrozole
Pronunciation : an as' troe zole
Therapeutic Classification : antiestrogens
Trade Name(s):
India- Altraz Tab, Altrol Tab, Anabrez Tab, Arimidex Tab, Armotraz Tab, Redest Tab, Stazonex Tab. International-Arimidex. This medication is prescribed for early breast cancer in women who have experienced menopause including women with disease progression after tamoxifen therapy. It is a non-steroidal aromatase inhibitor. It decreases the amount of estrogen the body makes. When it is not to be taken (Contraindications):
When it is to be taken : Adjuvant treatment in early breast cancer; Advanced or locally advanced breast cancer in postmenopausal women: 1 mg/day. How it should be taken : This medication available in the form of tablets to take by mouth once a day, with or without food. Special Instruction : *Caution should be exercised in patients with history of moderate or severe liver impairment, excess fat. *It may cause dizziness. Do not drive a car or operate machinery while driving this medication. * Avoid alcohol consumption. *Do the lab test for menopause if status is doubtful. *Bone mass density (bone mineral density) test should be conducted at the start of the therapy and at regular intervals thereafter. Side Effects : Heart- Widening of blood vessels, hypertension, sudden cardiac death, blood clot in veins and insufficient blood supply to brain. Central Nervous System- Lack of energy, mood disturbances, headache, depression, sleeplessness, dizziness, abnormal sensations, anxiety, increased tightness of muscle and fatigue. Skin- Rash, sweating, redness of the skin, mucous membrane infection. Eye and ENT- Inflammation of pharynx and clouding of eye lenses. Gastrointestinal- Stomach disturbances, nausea, vomiting, abdominal pain, constipation, diarrhea, loss of appetite, indigestion, gastrointestinal disorder and dry mouth. Genitourinary- Breast pain, urinary tract infection, inflammation of vagina, breast neoplasm, vaginal bleeding, whitish or yellowish vaginal discharge and vaginal dryness. Blood-Lymphatic- Lymph nodes swelling, decrease in hemoglobin, and white blood cells. Liver- Increased level of liver enzymes and jaundice. Hypersensitivity- Allergic reactions including hypersensitivity reaction, rapid swelling of the dermis and skin rash. Metabolic-Nutritional- Edema, high blood cholesterol and weight gain. Musculoskeletal- Inflammation of joints, joint pain, back pain, bone pain, an increased risk of fracture, pelvic pain and muscle pain. Respiratory-Difficulty in breathing, increased cough, sinus or sinusitis and inflammation of bronchus. Miscellaneous- Hot flashes, pain, accidental injury, infection, chest pain, flu syndrome, cyst, neoplasm and tumor flare. * Monitor cholesterol levels and bone mineral density periodically. Storage Conditions : Oral: Store at 20-25�C. Store it in airtight container. |
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