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Anakinra

Latest prescription information about Anakinra. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Anakinra
Pronunciation : an-ah-KIN-rah
Therapeutic Classification : Antirheumatics
ICD Code : Y45.4
Trade Name(s): 
International- Kineret.
Why it is prescribed (Indications) : 
This medication is a recombinant human interleukin 1 antagonist, prescribed for reducing the pain and swelling associated with moderate to severe rheumatoid arthritis either alone or in combination with methotrexate. It inhibits the binding of the interleukin 1 to its receptor. 
When it is not to be taken (Contraindications): 
Hypersensitivity to Escherichia coli -derived proteins, anakinra, or any component of product.

Pregnancy Category :

A B C D X
Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Dosage & When it is to be taken : 
SC- The recommended dose is 100 mg/day.
How it should be taken : 
It comes as a solution for injection, administered subcutaneously by a healthcare provider once a day, at the same time every day.
Warnings and Precautions : 
*Avoid vaccination while taking this medication.
*Swelling or bruising at the injection site occurs; apply a cold pack on the injection site immediately after injection.
*It should not be used in children.
*Caution needed for patients with history of infection, asthma, HIV infection or AIDS, or kidney disease, during pregnancy and breast feeding.
*Do not reuse needles, syringes, or other materials.
Side Effects : 
Most Common- Injection site reactions such as redness, bruising, swelling, and pain, chest infection, worsening of condition, urinary tract infection, headache, nausea, diarrhea, sinusitis, joint pain, flu like-symptoms, and abdominal pain.
Other Precautions : 
*Patient may experience a decrease in neutrophil counts, monitor complete blood count regularly.
Storage Conditions : 
Store it in refrigerator (2 to 8°C). Do not freeze it. Keep away from children.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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