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Ampicillin/Sulbactam

Latest prescription information about Ampicillin/Sulbactam. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Ampicillin/Sulbactam
Pronunciation : am- pi- sill' in- sul- bak' tam
Trade Name(s): 
India- Amisul Vial, Ampitum Vial, Ampy S Inj Vial, Ampysul Vial, Betamp Vial, Cinclox-S Vial, Osocillin-S Inj, Reopin-Sb Inj, Saltum Inj Vial, Sulbacin Tab, Sulbacin Vial.
International- Unasyn.
Why it is prescribed (Indications) : 
This medication is a penicillin antibiotic, prescribed for susceptible bacterial infections like skin infections, gynecological infections or infections of the abdomen either alone or with other medications. It blocks the bacteria's cell wall growth, which kills the bacteria. Sulbactam blocks the enzyme which breaks down ampicillin and thereby allows ampicillin to attack and kill the bacteria.

When it is not to be taken (Contraindications): 


Allergic to penicillins, infectious mononucleosis (kissing disease).

Pregnancy Category :

A B C D X
Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.


When it is to be taken : 
Dose is based on ampicillin dose. IV Endocarditis 2g 6 hourly for 4-6 week with gentamicin or vancomycin. Aspiration, community-acquired pneumonia 1-2g 6 hourly. Hospital-acquired pneumonia 2g 6 hourly. IV/IM Susceptible infections 1-2g 6 hrly. Max: 8 g/day. Uncomplicated gonorrhoea 1-2g as single dose, may use with oral probenecid. Acute pelvic inflammatory disease 2g 6 hourly with IV or oral doxycycline. Discontinue parenteral treatment 24 hr after clinical improvement; continue oral doxycycline to complete 14 days of treatment. The total dose of sulbactam should not exceed 4gms per day.
How it should be taken : 
It comes as a solution for injection, to be administered by a healthcare provider into the large muscle or the vein. It also comes as a tablet for oral use.
Special Instruction : 
*Monitor for signs of anaphylaxis, blood count, kidney and liver function, signs of super infections with mycotic or bacterial pathogens during treatment.
*Prolonged use may increase the risk of fungal infection.
*Caution needed during pregnancy and lactation.
* It should not be mixed with aminoglycosides while administering into the vein.
Side Effects : 
Local- Pain at injection site.
Central Nervous System- Fatigue and malaise.
Gastrointestinal- Upset stomach, gas, nausea, and diarrhea.
Allergic reactions- Itching, swelling of the face/hands/feet, difficulty in breathing, dizziness, chest pain, skin rash, unusual bleeding or bruising, sore throat, difficult or painful urination and swollen tongue.
Other Precautions : 
* Keep this product, as well as syringes and needles, out of the reach of children and pets.
Storage Conditions : 
Injection: Store dry powder at 20-25�C. Store it at room temperature.

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