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Amobarbital

Latest prescription information about Amobarbital. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Amobarbital
Pronunciation : am- oh- bar'- bi- tal
Therapeutic Classification : ANXIOLYTICS, SEDATIVES AND HYPNOTICS
ICD Code : Y47.5
Trade Name(s): 
International- Amytal.
Why it is prescribed (Indications) : 
This medication is a barbiturate derivative, prescribed for anxiety, insomnia and induction of preanesthetic sedation.  It alters cerebellar function and produces drowsiness, sedation and hypnosis
When it is not to be taken (Contraindications): 
Contraindicated in patients with history of acute or chronic pain, respiratory disease, severe liver impairment, porphyria and hypersensitivity.

Pregnancy Category :

A B C D X
Category D : There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
Insomnia- Adults - PO/IM/IV 65 to 200 mg at bedtime.
Sedation- Adults - PO/IM/IV 30 to 50 mg twice daily or 3 times daily.
Children - PO/IM 2 to 6 mg/kg/dose.
How it should be taken : 
It comes as a solution for injection to be administered by a healthcare provider into the vein or large muscle.
Warnings and Precautions : 
* Caution should be exercised in patients with history of liver or kidney disease, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.
* Avoid long-term use of this medication; otherwise patient may get addicted to this drug.
* Avoid rapid administration; otherwise it may lead to breathing problem.
* Avoid alcohol consumption.
Side Effects : 
Heart - Slow heart rate, low blood pressure and fainting.
Central Nervous System - Drowsiness, agitation, confusion, headache, in coordination, CNS depression, excitement, abnormal dreams, mental disturbances, hallucinations, sleeplessness and dizziness.
Gastrointestinal - Nausea, vomiting and constipation.
Blood - Blood disorders.
Liver - Liver damage.
Respiratory - Shortness of breath, difficulty in breathing and asthma.
Miscellaneous - Hypersensitivity reactions (eg, swelling, rashes, exfoliative dermatitis), fever and injection site reactions (eg, local pain, thrombophlebitis).
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it at controlled room temperature (15° to 30°C), and in an airtight container. Keep away from children.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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