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Amiodarone
Latest prescription information about Amiodarone. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Amiodarone
Pronunciation : A-mi-OH-da-rone
Therapeutic Classification : antiarrhythmics
Trade Name(s):
India- Aldarone Inj, Amiodar Tab, Amiodon Inj, Biodaron Tab, Cardasol Amp, Cardichek Inj, Cordarone Inj, Cordarone Tab, Cordarone X Amp, Cordarone X Tab, Duron Inj, Duron Tab, Eurythmic Amp, Eurythmic Tab, Panaron Tab, Ritebeat Tab, Ritebeat Vial, Tachyra Tab. International- Cordarone and Pacerone. This medication is used to treat life-threatening irregular heart rhythms (arrhythmias) and to maintain a normal heart rate in patients who have not responded to other medications. It is an antiarrhythmic drug. When it is not to be taken (Contraindications):
When it is to be taken : Oral:Ventricular arrhythmias- Adult: 800-1,600 mg/day in 1-2 divided doses for 1-3 week until initial therapeutic response is achieved then reduce dose to 600-800 mg/day in 1-2 divided doses for 1 month. Maintenance: 400 mg/day; lower doses may be used for supraventricular arrhythmias. Close monitoring of the patient is recommended. Use the minimum effective dose. Liver impairment: Dosage reduction may be necessary. IV Recommended starting dose is approximately 1,000 mg over the first 24 h administered as follows: rapid administration of 150 mg over first 10 min (15 mg/min), followed by 360 mg over next 6 h (1mg/min), then 540 mg over remaining 18 h (0.5 mg/min). After first 24 h, continue maintenance infusion rate of 0.5 mg/min (720 mg/24 h). How it should be taken : It comes as a tablet to take by mouth. It is usually taken once or twice a day with or without food. (Take consistently with or without meals. Take with meals if high dose or to reduce GI discomfort.). Injection administered into the vein by a health care provider. Special Instruction : * Close monitoring is recommended as AMIODARONE may worsen arrhythmia especially when used concurrently with other anti-arrhythmic drugs or drugs that prolong QT interval. * Corneal refractive laser surgery is not recommended in patients on amiodarone treatment. * It may cause hypotension and slow heart beat, increase risk of liver toxicity, visual disturbance/impairment; lung damage; monitor for pulmonary toxicity e.g. acute respiratory distress syndrome. * Monitor liver functions regularly. * It may affect defibrillation or pacing thresholds of cardiac devices. * Correct electrolyte imbalance before starting treatment. * Caution when used in patients undergoes surgery, hepatic impairment, thyroid disease, elderly, breast feeding. Side Effects : Heart- Abnormal heart rhythm, heart failure, heart attack, low blood pressure, sinus arrest. Central Nervous System- Abnormal gait/ lack of coordination, dizziness, fatigue, uneasiness, tingling, tremor/abnormal involuntary movement, headache, sleep disturbances, confusion, delirium, disorientation, pseudotumor cerebri( increased pressure inside the skull). Skin- Sensitivity to sunlight, flushing, redness, severe allergic reactions, itching, blue-gray discoloration, skin cancer. Eye and ENT- Visual disturbances, abnormal smell sensation, ringing in the ears, may lead to blindness. Gastrointestinal- Nausea, vomiting, loss of appetite, constipation, abdominal pain, abnormal salivation, abnormal taste, inflammation of pancreas. Genitourinary- Acute kidney failure, inflammation of testis, impotence, decreased sexual activities. Blood- Blood clot abnormalities, anemia, and decrease in blood cells. Liver- Abnormal liver function tests, liver disorders, jaundice. Local- Swelling, redness, necrosis, pain, inflammation , blood clot. Musculoskeletal- Muscle weakness, muscle pain, muscle damage. Respiratory- Cough, difficulty in breathing, lung infiltrates, wheezing, lung inflammation, fibrosis. Miscellaneous- It may cause severe allergic reactions, leg swelling , fever and increased secretion of antidiuretic hormone. It interferes with thyroid function and may increase or decrease thyroid hormone levels. * Avoid excessive sunlight exposure due to increased risk of photosensitivity Storage Conditions : Injection: Store at 15-25°C. Store it in airtight container and keep away from children. |
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