Generic Name : Amifostine Pronunciation : A-mi-FOS-teen Therapeutic Classification : Contraceptives
India- Amfos Vial, Amiphos Inj, Cytofos Vial, Ethyol Vial, M-Fost Vial, Naprofos Vi.
International- Ethyol. Why it is prescribed (Indications) :
This medication is a cytoprotective agent, prescribed for preventing kidney damage due to chemotherapy and reducing the mouth dryness due to radiation therapy. When it is not to be taken (Contraindications):
Contraindicated in patients with low BP, dehydration, patients with kidney or liver disease, children and elderly >70 years, and hypersensitivity.
Dosage & When it is to be taken :
As a cell protective agent in chemotherapy and radiation.
Adult: Initially, 910 mg/m2 BSA once daily, as an infusion given over 15 minutes, 30 minutes before start of chemotherapy. May reduce to 740 mg/m2 if patient is unable to tolerate the full dose.
For patients receiving cisplatin- <100 mg/m2, a dose of 740 mg/m2 may be given to reduce renal toxicity.
Prophylaxis of dry mouth in patients undergoing radiotherapy for head and neck cancer- Adult: 200 mg/m2 BSA once daily, as an infusion given over 3 minutes, beginning 15-30 minutes before radiotherapy. How it should be taken :
This medication available in the form of injection, administered by the healthcare providers. Warnings and Precautions :
*Caution needed for pregnant women and breast feeding.
*Patients should drink water adequately to avoid dehydration.
*Prolonged infusion causes greater side effects.
*Stop antihypertensive drugs one day before infusion.
*Take antiemetics (drug against vomiting and vomiting sensation) before infusion especially if the treatment causes vomiting. Side Effects :
Heart-Low blood pressure during infusion, fall in pulse pressure.
Central Nervous System- Transient and reversible loss of consciousness rarely, dizziness, drowsiness.
Miscellaneous- Flushing, feeling of warmth, chills, sneezing, cough and skin rashes.
*Monitor blood pressure regularly, at least before and immediately after infusion. Storage Conditions :
Intravenous: Vials containing lyophilized powder: Store at 20-25°C. Reconstituted solution (500 mg/10 mL): Chemically stable for up to 5 hr at room temperature (about 25°C) or up to 24 hr under refrigeration (2-8°C).
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