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Alteplase
Latest prescription information about Alteplase. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Alteplase
Pronunciation : AL-teh-PLACE
Trade Name(s):
India- Actilyse Vial. International- Cathflo Activase. This medication is an enzyme (tissue plasminogen activator (tPA)), prescribed for heart attack, stroke, and pulmonary embolism. It helps to break down unwanted blood clots. When it is not to be taken (Contraindications):
When it is to be taken : Adult: Acute massive pulmonary embolism- Total dose: 100 mg (not >1.5 mg/kg for patients weighing <65 kg). 10 mg as bolus, followed by infusion of the remainder dose over 2 hour. Acute stroke: 0.9 mg/kg (not more than 90 mg) IV over 1 hour. The first 10% should be administered in 1 minute. Heart attack: For patients weighing > 67 kg, 15 mg iv, followed by 50 mg over the next half an hour, and then 35 mg over the next 1 hour. The total dose of 100 mg may also be administered over 3 hours. How it should be taken : It comes as a solution for injection, to be injected by a healthcare provider into the vein. Special Instruction : *It may lead to serious bleeding, contact your doctor immediately. *Caution should be exercised in children, elderly, pregnant women, and patients with kidney disease. *Monitor for intracranial bleeding and blood pressure in acute stroke. Side Effects : Potentially Fatal- Bleeding in the brain. Heart - Heart failure, abnormal heart rhythm and heart arrest. Central Nervous System - Cerebral edema (increased fluid content in the brain). Miscellaneous- Allergic reactions, nausea, vomiting, low blood pressure and fever. *Caution needed when administered with other drugs such as heparin and aspirin. Storage Conditions : Injection: Store it at room temperature (<30°C) or under refrigeration. |
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