Aliskiren and Amlodipine - Drug Information

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General Information on Aliskiren and Amlodipine

Generic Name : Aliskiren and Amlodipine

Latest prescription information about Aliskiren and Amlodipine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y52.5 | Therapeutic Classification : Anti- Hypertensives

Trade Names/Brand Names of Aliskiren and Amlodipine

International- Tekamlo.

Why is Aliskiren and Amlodipine Prescribed? (Indications)

This combination medication contains renin inhibitor and calcium channel blocker, prescribed for high blood pressure.  Amlodipine relaxes (widens) blood vessels where as Aliskiren inhibits renin and increase the blood flow.

When should Aliskiren and Amlodipine not to be taken? (Contraindications)

Contraindicated in patients with diabetes, and hypersensitivity.
Do not use aliskiren with angiotensin receptor blockers (ARBs) and the angiotensin converting enzyme inhibitors (ACEIs)in patients with diabetes.

Pregnancy Category

A B C D X

Category D :

There is an evidence of fetal risk based on adverse reaction data, but potential benefits may allow the drug to be used in pregnant women despite risks.

What is the dosage of Aliskiren and Amlodipine?

The recommended initial once-daily dose is 150mg/5 mg. Titrate as needed to a maximum of 300-mg/10 mg.

How should Aliskiren and Amlodipine be taken?

It comes as a tablet to take by mouth, with or without food.

What are the warnings and precautions for Aliskiren and Amlodipine?

Caution should be exercised in patients with history of angioedema, dehydration, low blood volume, high blood potassium, low-salt (sodium) diet, gout, heart, liver or kidney disease, low blood pressure, blood vessel problems, diabetes, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.
It may cause dizziness, lightheadedness, or fainting, do not drive a car or operate machinery and get up slowly from bed while taking this medication.
It may cause a serious side effect called angioedema, with the following symptoms: swelling of the hands, face, lips, eyes, throat, or tongue; difficulty in swallowing or breathing or hoarseness. If it is so consult with your healthcare provider.
Monitor blood pressure, kidney function, and blood electrolyte levels.

What are the side effects of Aliskiren and Amlodipine?

  Gastroenterology: Diarrhea, abdominal pain, indigestion, and gastroesophageal reflux.
   Heart : Abnormal heart rhythm, slow heart rate, chest pain, fainting, low blood pressure, inflammation of blood vessels.
   Central Nervous System : Sensory loss, tingling, tremor, sexual dysfunction, sleeplessness, nervousness, depression, abnormal dreams, anxiety, and depersonalization.
   Gastrointestinal : Loss of appetite, constipation, difficulty in swallowing, flatulence, inflammation of pancreas, vomiting, gum swelling.
   General : Allergic reaction, weakness, back pain, hot flushes, uneasiness, pain, rigors, weight gain, weight decrease.
   Musculoskeletal : Joint pain, muscle pain, degenerative disease of a joint, muscle cramps.
   Respiratory : Difficulty in breathing, nosebleed.
   Skin : Angioedema, itching, rash.

What are the other precautions for Aliskiren and Amlodipine?

Avoid excess dosage.

What are the storage conditions of Aliskiren and Amlodipine?

Store at 25C. Protect from heat and moisture.

♦ Safety Labeling Changes Approved By FDA

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