Alectinib - Drug Information

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Last Updated : 9/23/2016

General Information on Alectinib

Generic Name : Alectinib

Latest prescription information about Alectinib. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.

Trade Names/Brand Names of Alectinib

Alecensa

Why is Alectinib Prescribed? (Indications)

Alectinib belongs to a group of medicines known as kinase Inhibitors. It is prescribed for the treatment of a certain type (anaplastic lymphoma kinase (ALK)-positive) of non-small cell lung cancer that has spread to other parts of the body. It is given for patients who cannot take another drug, crizotinib, or in those in whom crizotinib was ineffective. It may slow down or stop the growth and spread of cancer cells by specifically blocking the protein which signals them to multiply. 

When should Alectinib not to be taken? (Contraindications)

Alectinib should not be used in patients who are allergic to the drug, patients with the history of liver or lung disease, exposure to excessive sunlight, during pregnancy or breast feeding.

What is the dosage of Alectinib?

The recommended dose of alectinib is 600mg to be taken twice daily with food.

How should Alectinib be taken?

Alectinib comes in the form of a capsule of 150mg each to be taken twice a day with food. Do not open or crush the capsule; it should be swallowed as a whole.

What are the warnings and precautions for Alectinib?

Alectinib should not be used during pregnancy or breast feeding as it may harm the fetus. Men and women should use contraceptives during treatment. Women should continue the use of birth control methods for at least a week after the end of treatment, while men should use contraceptives for three months following the last dose.
Avoid prolonged exposure of sunlight and use a sunscreen and lip balm with a sun protection factor (SPF) of 50 or more while taking alectinib and for a week after the last dose as the drug is capable of making the skin sensitive to sunlight.

What are the side effects of Alectinib?

  General: Muscle pain, weakness, swelling in the hands and the feet, increased weight.
  Gastrointestinal: Constipation, diarrhea, nausea and vomiting, stomach pain, loss of appetite.
  Skin: Rash
  Central Nervous System: Headache
  Respiratory System: Cough, lung disease, difficulty in breathing.
  Eye: Blurred vision, changes in vision.
  Cardiovascular System: Chest pain, reduced heart rate, fainting.
  Liver: Liver damage resulting in yellowing of skin and white of eyes, dark urine and itchy skin.

What are the other precautions for Alectinib?

Do not take double the dose of the drug to compensate the missed dose.
Doctors must inform patients about side effects of muscle pain and pneumonia while prescribing the drug.

What are the Drug Interactions of Alectinib?

Avoid the use of alectinib with any other drug which can reduce heart rate due to possible additive effect.

What are the storage conditions of Alectinib?

Store the medicine in a tightly closed container at room temperature. Protect from excess heat, light and moisture. Keep out of reach of children.

Last Updated : 9/23/2016

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