Generic Name : Aldesleukin Pronunciation : al-dess-LEW-Kin Therapeutic Classification : Chemotherapy ICD Code : Y43.3
International- Proleukin. Other Name : IL-2, Interleukin-2, r-serHuIL Why it is prescribed (Indications) :
This medication is an antineoplastic agent, prescribed for metastatic renal cell carcinoma. It is a man-made version of a substance called interleukin-2 which are produced naturally by cells in the body. When it is not to be taken (Contraindications):
Contraindicated in patients who have a history of an abnormal heart stress test or lung function test, heart rate or rhythm, re-treatment in patients who have experienced with drug-related toxicities.
Dosage & When it is to be taken :
Adults - IV- 600,000 units/kg every 8 h by a 15 min infusion for 14 doses. Repeat regimen after 9 days recovery for a total of 28 doses/course. How it should be taken :
It comes as a powder for injection (diluted with fluid) to be administered by a healthcare provider into the vein. Warnings and Precautions :
* Caution should be exercised in patients with history of heart, lung, brain, kidney, liver, or autoimmune disease, infection, central nervous system disorder, any allergy, who are taking other medications, during pregnancy and breastfeeding.
* It may cause drowsiness or dizziness, do not drive a car or operate machinery while taking this medication.
* It may reduce platelet counts; avoid injury or bruising.
* Avoid contact with people who have infections.
* Monitor complete blood cell counts, kidney and liver tests, and lung function tests regularly while taking this medication. Side Effects :
Body as a Whole - Chills, fever, uneasiness, weakness, infection, abdominal pain, acidity and abdominal bloating.
Metabolic - Elevated liver enzymes, weight gain and fluid retention.
Heart - Low blood pressure and fast heart rate.
Central Nervous System - Dilatation of blood vessels, confusion, drowsiness, anxiety and dizziness.
Gastrointestinal - Diarrhea, mouth ulcer, nausea, vomiting and loss of appetite.
Respiratory - Respiratory disorder, increased cough, runny nose and difficulty in breathing.
Skin - Rash, itching and skin inflammation.
Blood - Anemia and decrease in white blood cells.
Genitourinary - Decreased urination.
* Avoid excess dosage. Storage Conditions :
Store it in a refrigerator (2° to 8°C).
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