Ado-trastuzumab Emtansine - Drug Information

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General Information on Ado-trastuzumab Emtansine

Generic Name : Ado-trastuzumab Emtansine

Latest prescription information about Ado-trastuzumab Emtansine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.

Trade Names/Brand Names of Ado-trastuzumab Emtansine

International- Kadcyla.

Why is Ado-trastuzumab Emtansine Prescribed? (Indications)

This medication is a HER2-targeted antibody and microtubule inhibitor, prescribed as a single medicine for the treatment in patients with HER2-positive metastatic breast cancer who have previously received trastuzumab and a taxane separately or in combination. Patients should have either received prior therapy for metastatic disease, or developed disease recurrence during or within six months of completing adjuvant therapy. .  

When should Ado-trastuzumab Emtansine not to be taken? (Contraindications)

None.

What is the dosage of Ado-trastuzumab Emtansine?

IV- The recommended dose is 3.6 mg/kg every 3 weeks (21-day cycle).

How should Ado-trastuzumab Emtansine be taken?

It comes as powder for injection (diluted with fluid), to be administered by a healthcare provider into the vein.

What are the warnings and precautions for Ado-trastuzumab Emtansine?

Caution should be exercised in patients with history of liver or heart problem, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.
Ado-trastuzumab emtansine should not be administered at doses greater than 3.6 mg/kg.
Should not substitute for or with trastuzumab.
Monitor platelet counts prior to each dose of this drug administration.
Perform HER2 testing while taking this medication.
Discontinue this medication in patients diagnosed with interstitial lung disease or pneumonitis.

What are the side effects of Ado-trastuzumab Emtansine?

   Serious Effects : Lung problems, injection site reactions, nerve damage, heart damage, embryo-fetal toxicity.
   Most Common : Fatigue, nausea, muscle and bone pain, decrease in platelet counts, headache, increased level of liver enzymes and constipation.
   Miscellaneous : Tiredness, liver problems, nerve problems.

What are the other precautions for Ado-trastuzumab Emtansine?

Avoid excess dosage.

What are the storage conditions of Ado-trastuzumab Emtansine?

Store vials in a refrigerator at 2C to 8C.

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