Adalimumab - Drug Information

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General Information on Adalimumab

Generic Name : Adalimumab

Pronunciation : a dal aye' mu mab

Latest prescription information about Adalimumab. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y45.4 | Therapeutic Classification : Antirheumatics

Trade Names/Brand Names of Adalimumab

International- Humira.

Why is Adalimumab Prescribed? (Indications)

This medication is a tumor necrosis factor alpha (TNF alpha) inhibitor, prescribed for rheumatoid arthritis, crohn's disease (digestive tract inflammation), psoriatic arthritis, ulcerative colitis, plaque psoriasis, ankylosing spondylitis (spine infammation), and juvenile idiopathic arthritis (joint inflammation in children). It blocks the effect of TNF and thereby reduces the inflammation and its consequences in the joints and intestine. 

When should Adalimumab not to be taken? (Contraindications)

Hypersensitivity.

Pregnancy Category

A B C D X

Category C :

Animal studies have shown adverse effects on the fetus and there are no appropriate studies in pregnant women, but potential benefits may allow the use of the drug in pregnant women despite the potential for risks.

What is the dosage of Adalimumab?

SC- The recommended dose is 40mg to 80 mg, every two weeks; it may be increased if needed.
Juvenile Idiopathic Arthritis- 15 kg (33 lbs) to <30 kg (66 lbs): 20 mg every two weeks ≥30 kg (66 lbs): 40 mg every two weeks.

How should Adalimumab be taken?

It comes as a solution to inject under the skin (subcutaneous), by a healthcare provider.

What are the warnings and precautions for Adalimumab?

• It may cause serious infection, which leads to death, contact your healthcare provider immediately if you have any signs of infection such as fever, cough, or flu-like symptoms.
• Perform lab test for tuberculosis before treatment. Monitor every patient for active tuberculosis while taking this medication.
• Tuberculosis treatment should be given prior to this medication.
• In some patients it may develop cancer like lymphoma.
• Caution should be exercised in patients with cancer, multiple sclerosis, heart disease, during pregnancy and breastfeeding.

What are the side effects of Adalimumab?

•  Serious: Infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body , liver failure, blood clot in the lung, cerebrovascular accident, and cancer.
•  Most common: Injection site reactions, fever, joint pain, numbness, tingling and swelling in the face, tongue, ankles and lower leg regions, headache, rash, nausea and stomach upset.
•  Respiratory : Upper respiratory tract infection, asthma, sinusitis and flu syndrome.
•  Gastrointestinal : Feeling full, loss of appetite, pain in you’re the upper stomach that may spread to the shoulder.
•  Skin : Redness, rash, itching, bruising and pus filled skin eruptions.
•  Central Nervous System : Dizziness, confusion and tremor.
•  Respiratory : Difficulty in breathing.
•  Heart : Cardiovascular disorder, chest pain and heart attack.
•  Eye : Vision problems (cataract).
•  Laboratory Test: High cholesterol in blood, reduced levels of platelets and red cells, blood in urine and increase in the liver enzymes.
•  Miscellaneous : Accidental injury, back pain, urinary tract infection, weight loss, tiredness and high blood pressure.

What are the other precautions for Adalimumab?

Avoid vaccination while taking this medication.

What are the storage conditions of Adalimumab?

Refrigerate at 36°F to 46°F (2°C to 8°C) in an airtight container. Do not freeze. Do not use if frozen even if it has been thawed. When traveling, store HUMIRA in a cool carrier with an ice pack. Protect from light.

♦ Safety Labeling Changes Approved By FDA

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Please note for the minimum order for Exports is of US$ 200. All orders will be subject to courier charges and supplies are normally dispatched through internationally accredited courier services.

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sangey 

Hi i have a patient of ulcerative colitis and i want to start adalimumab kindly send me cost price and transportation facility, and i am a gastroenterologist in sikkim.

koomar.59 

I am a Professor in Pharmacology serving in Medical schools for over 33years now in India. My wife has Crohn 's colitis. I am not in a position to purchase Adalimumab for her. I want to write to the manufacturer and ask whether the drug may be sent at reduced rate. Anyone who has the address, please let me know.

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