Why it is prescribed :
This combination medication contains a nucleoside reverse transcriptase inhibitor (NRTI), prescribed for HIV-1 infection. It works by preventing human immunodeficiency virus (HIV) cells multiplication in your body.
When it is not to be taken (Contraindications):
Category C :
Animal studies have shown adverse effects on the fetus and there are no appropriate studies in pregnant women, but potential benefits may allow the use of the drug in pregnant women despite the potential for risks.
Dosage & When it is to be taken (Indications):
The recommended oral dose is one tablet twice daily. Weight should be at least 40 Kg.
How it should be taken :
It comes as a tablet which contains abacavir, lamivudine and zidovudine.(300 mg / 150 mg / 300 mg) to take by mouth, with or without food.
Warnings and Precautions :
Caution should be exercised in patients with history of kidney problems, heart disease, high blood pressure, high cholesterol, diabetes, bone marrow depression, muscle disorders, smoking, alcoholism, hepatitis B infection, breathing problem, nerve disorders, obesity, poor immunity, abdominal pain, diarrhea, nausea, vomiting, cough, sore throat, fever, fatigue, rash, any allergy, who are taking other medications, during pregnancy and breastfeeding.
It may cause dizziness, do not drive a car or operate machinery while taking this medication.
It should not be used in children.
It does not stop the spread of infection to others; avoid sexual contact, sharing of needles, injection supplies.
Side Effects :
Nausea, vomiting, headache, uneasiness, fatigue, diarrhea, fever, chills, depressive disorders, musculoskeletal pain, rash, throat infections, anxiety.
Body as a Whole
Redistribution/accumulation of body fat.
Endocrine and Metabolic
Breast enlargement in males, sugar.
Loss of appetite, abdominal pain, indigestion, darkening of skin.
Inflammation of blood cells, weakness.
Anemia, swelling of lymph nodes, decrease in platelets.
- Lactic acidosis and hepatic steatosis (fatty liver), elevated bilirubin, elevated transaminases, posttreatment exacerbation of hepatitis B, jaundice (yellowing of the skin or eyes).
Joint pain, muscle pain, muscle weakness, symptomatic myopathy(diseases of skeletal muscle), CPK elevation, breakdown of muscle fibers.
Central Nervous System
Dizziness, tingling, nerve disease, seizures, sleeplessness, and other sleep disorders.
Abnormal breath sounds/wheezing, difficulty in breathing.
Hair loss, redness, Stevens-Johnson syndrome, darkening of skin, rash, hives.
Other Precautions :
Avoid excess dosage.
Storage Conditions :
Store it at controlled room temperature (15° to 30°C).