1. Clarithromycin exhibits BACTERICIDAL activity against H.influenzae, S.pneumoniae, S.pyogenes,S.agalactia etc.,

2. It has good activity against many respiratory pathogens causing atypical pneumonia specifically very effective against L.pneumophiliae etc.,

3. In addition to its antibacterial activity, clarithromycin exhibits   

(1) Improvement in immune function  

(2) reduced the visco-elastic property of the mucus and sputum

1. Claritheomycin has consistent p.o absorption with good oral bioavailability exhibiting high concentrations in lung, tonsils, nasal tissue, middle ear, and WBCs etc.,

2. No need for adjustment of dosage in older patients and with mild hepatic impairment and renal impairment (except in Creatinine 30ml/mt)

3. Clarithromycin has greater activity against opportunistic infections associated with AIDS like MAC, T.gondii, and Cryptosporidiosis with very little or no interaction with new Anti HIV proteases used in AIDS.

4. Clarithromycin has greater activity against T.gondii when combined with pyrimethammine although secondary to cotrimoxazole

5. Clarithromycin has excellent activity against M.chelonae as mono-therapy in this refractory disseminated infection

6. Recent studies have clearly shown that clarithromycin is highly effective against B.burgdorferi the tick borne Lyme disease and associated arthritis.

7. Clarithromycin produced better clinical success and bacteriological eradication rate in chest infections like Acute bronchitis, Acute Exacerbation of Chronic Bronchitis (AECB), Community acquired pneumonia, otitis media etc.,

8. Clarithromycin is an important second line drug in leprosy and given in combination with minocycline.