http://www.medindia.net/healthnews/Leucopenia-news.asp Medindia largest health website in india. en-us Copyright 2012. All Rights Reserved. Fri, 25 May 2012 06:27:39 GMT http://www.medindia.net/news/commonly-used-chemo-drug-could-aid-the-spread-of-cancer-cells-into-bones-by-fertilizing-bone-marrow-101405-1.htm A new study conducted by researchers at University of Michigan School of Dentistry has found that instead of preventing the spread of cancer, a commonly used chemotherapy drug fertilizes the bone marrow, allowing cancer cells to multiply and spread easily, if it is administered before bone tumors took root. The findings provide valuable insight as to why some cancers metastasize to bone, and could eventually result in new metastasis-prevention drugs, said Laurie McCauley, professor in the Department ...]]> http://www.medindia.net/news/commonly-used-chemo-drug-could-aid-the-spread-of-cancer-cells-into-bones-by-fertilizing-bone-marrow-101405-1.htm http://www.medindia.net/news/treatment-of-heart-failure-with-bone-marrow-cells-probed-by-study-99396-1.htm Using patient's bone marrow cells to treat chronic ischemic heart failure did not result in progress on most measures of heart function, states study appearing in IJAMA/I. The study is being published early online to coincide with its presentation at the American College of Cardiology's annual scientific sessions. Cell therapy has emerged as an innovative approach for treating patients with advanced ischemic heart disease, including those with heart failure. "In patients with ischemic heart ...]]> http://www.medindia.net/news/treatment-of-heart-failure-with-bone-marrow-cells-probed-by-study-99396-1.htm http://www.medindia.net/news/symptoms-of-rett-syndrome-in-mice-halted-by-bone-marrow-transplant-99170-1.htm A new study has revealed that using bone marrow transplant (BMT) to replace faulty immune system cells in mouse models of Rett Syndrome arrested many severe symptoms of the childhood disorder. The latter included abnormal breathing and movement, and significantly extended the rodents' lifespan. Exploring the function of microglia deficient in methyl-CpG binding protein 2 (Mecp2), the protein encoded by the "Rett gene," principal investigator Jonathan Kipnis, Ph.D. and his team at the University ...]]> http://www.medindia.net/news/symptoms-of-rett-syndrome-in-mice-halted-by-bone-marrow-transplant-99170-1.htm http://www.medindia.net/news/Court-Permits-Payment-for-Bone-Marrow-Donors-94364-1.htm ...]]> http://www.medindia.net/news/Court-Permits-Payment-for-Bone-Marrow-Donors-94364-1.htm http://www.medindia.net/news/Half-Match-Bone-Marrow-Transplant-Procedure-Shows-Promising-Results-90151-1.htm A clinical trial conducted at the Kimmel Cancer Center at Jefferson testing its unique, two-step half-match procedure has produced some promising results. The probability of overall survival was 45 percent in all patients after three years and 75 percent in patients who were in remission at the time of the transplant. Neal Flomenberg, M.D., Chair of the Department of Medical Oncology at Thomas Jefferson University Hospital, Dolores Grosso, DNP, Co-Principal Investigator and lead author of ...]]> http://www.medindia.net/news/Half-Match-Bone-Marrow-Transplant-Procedure-Shows-Promising-Results-90151-1.htm http://www.medindia.net/news/Acute-Stroke-can-be-Safely-Treated-by-Patients-Own-Bone-Marrow-Stem-Cells-90080-1.htm Using a patient's own bone marrow stem cells to treat acute stroke is feasible and safe, results of a groundbreaking Phase I trial at the University of Texas Health Science Center at Houston (UTHealth) have indicated. The trial was the first ever to harvest an acute stroke patient's own stem cells from the iliac crest of the leg, separate them and inject them back into the patient intravenously. The first patient was enrolled in March 2009 at Memorial Hermann-Texas Medical Center. "In ...]]> http://www.medindia.net/news/Acute-Stroke-can-be-Safely-Treated-by-Patients-Own-Bone-Marrow-Stem-Cells-90080-1.htm http://www.medindia.net/news/Study-Shows-How-Bone-Marrow-Transplantation-Promotes-Cancer-Resistance-in-Patients-89634-1.htm Bone marrow transplantation with genetically modified cells may prolong the period of cancer-free survival, suggests a study led by Dr. Vivek Rangnekar, associate director of translational research for the Markey Cancer Center at the University of Kentucky. Bone marrow, a spongy tissue inside bones, contains stem cells that produce blood cells, including leukocytes, erythrocytes and platelets. In the cover story of the July issue of ICancer Biology (and) Therapy/I, Rangnekar and his team explore ...]]> http://www.medindia.net/news/Study-Shows-How-Bone-Marrow-Transplantation-Promotes-Cancer-Resistance-in-Patients-89634-1.htm http://www.medindia.net/news/Heart-Repair-Using-Laser-treated-Bone-Marrow-Stem-Cells-88973-1.htm A new treatment developed at Tel Aviv University uses laser-treated bone marrow stem cells to help restore heart function and health. After a heart attack or stroke, heart scarring can lead to dangerously paper-thin heart walls and a decreased ability to pump blood through the body. Although the heart is unable to completely heal itself, this new treatment can help restore heart health. Combining the therapeutic benefits of low-level lasers - a process called "shining" - and bone marrow stem cells, Prof....]]> http://www.medindia.net/news/Heart-Repair-Using-Laser-treated-Bone-Marrow-Stem-Cells-88973-1.htm http://www.medindia.net/news/Survival-Improves-in-Bone-Marrow-Transplant-87798-1.htm In the recent years bone marrow transplant survival has more than doubled for young, high-risk leukemia patients. The results are believed to be the best ever reported for leukemia patients who underwent bone marrow transplantation. The findings are expected to make transplantation a treatment option for more children and adolescents with high-risk forms of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) who lack genetically matched donors, either related or unrelated....]]> http://www.medindia.net/news/Survival-Improves-in-Bone-Marrow-Transplant-87798-1.htm http://www.medindia.net/news/Bone-Marrow-Stem-Cells-may-Help-Treat-Traumatic-Brain-Injuries-82115-1.htm Scientists have safely used stem cells derived from a patient's own bone marrow in pediatric patients with traumatic brain injury (TBI). This was part of a Phase I clinical trial at The University of Texas Health Science Center at Houston (UTHealth). "Our data demonstrate that the acute harvest of bone marrow and infusion of bone marrow mononuclear cells to acutely treat severe TBI in children is safe," said Charles S. Cox, Jr., the study's lead author. The clinical trial, which included ...]]> http://www.medindia.net/news/Bone-Marrow-Stem-Cells-may-Help-Treat-Traumatic-Brain-Injuries-82115-1.htm http://www.medindia.net/news/Stem-Cell-Discovery-can-Lead-to-Efficient-Bone-Marrow-Transplants-79167-1.htm Researchers have identified an essential molecule for establishing blood stem cells in their niche within the bone marrow.The findings, reported in the January issue of ICell Stem Cell/I, could lead to improvements in the safety and efficiency of bone marrow transplants. Bone marrow transplants are a type of stem cell therapy used to treat cancers such as lymphoma and leukemia and other blood-related diseases. In a bone marrow transplant, the "active ingredients" are hematopoietic stem ...]]> http://www.medindia.net/news/Stem-Cell-Discovery-can-Lead-to-Efficient-Bone-Marrow-Transplants-79167-1.htm http://www.medindia.net/news/Brit-Boy-Gifts-Brother-Bone-Marrow-for-Christmas-78654-1.htm 9 year old Robert Sherwood in Britain is set to donate his bone marrow to his younger brother as a Christmas gift. Younger brother Edward 5 years old is diagnosed with aplastic anemia. Robert Sherwood begged his parents to let him take a blood test to see if he could help his brother who was suffering from the disease which causes his bone marrow not to produce enough new blood cells. The condition, which affects just two children in Britain every year, leaves sufferers at high risk from infections....]]> http://www.medindia.net/news/Brit-Boy-Gifts-Brother-Bone-Marrow-for-Christmas-78654-1.htm http://www.medindia.net/news/Bone-Marrow-Stem-Cells-May-Aid-In-Stroke-Recovery-Study-77539-1.htm A new research has found that bone marrow stromal stem cells may aid in stroke recovery. The study from the Farber Institute for Neurosciences and the Department of Neuroscience at Thomas Jefferson University found that systematic administration of bone marrow stem cells (MSC) administered to laboratory rats one day after their simulated strokes found "significant recovery" of motor behaviour on the first day. "The timing of stem cell treatment was critical to the magnitude of the positive effects," said Lorraine Iacovitti....]]> http://www.medindia.net/news/Bone-Marrow-Stem-Cells-May-Aid-In-Stroke-Recovery-Study-77539-1.htm http://www.medindia.net/news/Actor-Salman-Khan-Pledges-To-Donate-His-Bone-Marrow-76733-1.htm Bollywood actor Salman Khan has pledged to donate his bone marrow to spread awareness on stem cell donation. Khan urged people to donate their bone marrow to save lives. "It's simple to donate bone marrow. You don't have to spend money for it. I think everybody should go and donate bone marrow," said Khan. Bone marrow is used for transplants that are life saving for patients suffering from blood cancer, thalassemia, aplastic anemia, congenital immuno-deficiency states and other such blood related diseases....]]> http://www.medindia.net/news/Actor-Salman-Khan-Pledges-To-Donate-His-Bone-Marrow-76733-1.htm http://www.medindia.net/news/New-Research-Setting-the-Ground-for-Liver-Bone-Marrow-Regeneration-76719-1.htm A new study, by demonstrating that endothelial cells that play a key role, has shed light on how the liver regenerates itself by. Endothelial cells form the lining of blood vessels. The Weill Cornell Medical College scientists have uncovered the endothelial cells' 'instructive role' in liver regeneration. Further, the researchers believe that in the coming years it will be possible to facilitate healing damaged livers by transplanting certain types of endothelial cells with liver cells. ...]]> http://www.medindia.net/news/New-Research-Setting-the-Ground-for-Liver-Bone-Marrow-Regeneration-76719-1.htm http://www.medindia.net/news/Treatment-for-Rheumatoid-Arthritis-in-Bone-Marrow-Cancer-Drug-76298-1.htm A drug used to treat bone marrow cancer could also provide a promising treatment for rheumatoid arthritis (RA). The study conducted by Greek researchers has suggested that the biologic drug bortezomib (Velcade), a proteasome inhibitor used to treat multiple myeloma (bone marrow cancer), may be useful for RA as well. In the study, bortezomib displayed favorable effects in an animal model of inflammatory arthritis that mimics RA, in reducing disease severity and inflammation, and promoting bone healing....]]> http://www.medindia.net/news/Treatment-for-Rheumatoid-Arthritis-in-Bone-Marrow-Cancer-Drug-76298-1.htm http://www.medindia.net/news/Bone-Marrow-Transplant-Success-Rate-may-be-Improved-by-Inhibiting-Cell-Signaling-Pathway-74573-1.htm New research indicates that identification of a molecular communications pathway that influences the mobilization of hematopoietic stem cells could lead to targeted therapies for improving bone marrow transplant success rates. In a bed-side to bench approach, researchers at Cincinnati Children's Hospital Medical Center report Sept. 26 in INature Medicine/I that pharmacological inhibition of a signaling pathway triggered by Egfr (epidermal growth factor receptor) increased the mobilization of hematopoietic stem cells in mice....]]> http://www.medindia.net/news/Bone-Marrow-Transplant-Success-Rate-may-be-Improved-by-Inhibiting-Cell-Signaling-Pathway-74573-1.htm http://www.medindia.net/news/Compound-Administered-During-Some-Bone-Marrow-Transplants-is-Risky-74406-1.htm The risks associated with administering a specific compound in some forms of bone-marrow transplantation may be debated following research conducted at Oregon Health (and) Science University's Vaccine and Gene Therapy Institute. The research is published in the current edition of ICell Host and Microbe/I. The VGTI research team, led by institute director Jay Nelson, Ph.D., studies human cytomegalovirus, a virus that may infect up to 80 percent of the American population. The exact percentage ...]]> http://www.medindia.net/news/Compound-Administered-During-Some-Bone-Marrow-Transplants-is-Risky-74406-1.htm http://www.medindia.net/news/Bone-Marrow-Stem-Cells-Used-for-Heart-Attack-Proven-Safe-in-First-Clinical-Trial-74076-1.htm Researchers found that the first randomized, placebo-controlled U.S. clinical trial to assess the use of bone marrow-derived mononuclear cells (BMC) in patients after a ST-elevation myocardial infarction or severe heart attack, was safe. "The use of adult stem cells, derived from the patient's own bone marrow, presents a potential new type of therapy to benefit individuals after they suffer a heart attack," said the study's principal investigator Dr. Jay H. Traverse, cardiologist ...]]> http://www.medindia.net/news/Bone-Marrow-Stem-Cells-Used-for-Heart-Attack-Proven-Safe-in-First-Clinical-Trial-74076-1.htm http://www.medindia.net/news/Route-to-Healing-Blood-Vessels-may-Lie-Via-Selected-Cells-from-Blood-or-Bone-Marrow-72704-1.htm Research from Emory University School of Medicine says that isolating cells from a patient's blood or bone marrow that nourish blood vessels may be a safer and less arduous route to treatment of cardiovascular disease than obtaining rare stem cells. In recent clinical trials, doctors in several countries have tested the ability of a patient's bone marrow cells to repair damage, such as heart attacks and peripheral artery disease, created by problems of blood flow. "The focus has been on ...]]> http://www.medindia.net/news/Route-to-Healing-Blood-Vessels-may-Lie-Via-Selected-Cells-from-Blood-or-Bone-Marrow-72704-1.htm http://www.medindia.net/news/Bone-Marrow-Stem-Cells-Can-Help-Treat-Killer-Skin-Disease-72615-1.htm In two groundbreaking studies, doctors have used stem cells from bone marrow to help heal children with a killer skin disease, and to repair injured lungs. Researchers led by University of Minnesota doctors John Wagner and Jakub Tolar used bone marrow stem cells to treat children with a rare genetic skin disorder called recessive dystrophic epidermolysis bullosa (RDEB). The study was the first to show that bone marrow stem cells can be used to treat diseases affecting the skin and upper ...]]> http://www.medindia.net/news/Bone-Marrow-Stem-Cells-Can-Help-Treat-Killer-Skin-Disease-72615-1.htm http://www.medindia.net/news/Stanford-Study-Shows-Purified-Blood-Stem-Cells-Improve-Success-of-Bone-Marrow-Transplants-in-Mice-72248-1.htm A new study shows that mice receiving purified blood stem cells are less prone to complications than mice receiving stem cells plus purified T cells. With these results, researchers at the Stanford University School of Medicine have challenged decades of accepted wisdom about bone marrow transplantation. The study, led by Judith Shizuru, MD, PhD, associate professor of medicine, will be published online Aug. 2 in the IProceedings of the National Academy of Sciences/I. Bone marrow transplantation ...]]> http://www.medindia.net/news/Stanford-Study-Shows-Purified-Blood-Stem-Cells-Improve-Success-of-Bone-Marrow-Transplants-in-Mice-72248-1.htm http://www.medindia.net/news/Saliva-Test-to-be-Used-for-Bone-Marrow-Matches-70744-1.htm The leukemia charity, Anthony Nolan Trust, is to encourage people to spit so as to use saliva for matching bone marrows. The charity hopes that this measure will help double the number of lives saved. The process is also pretty simple. People who want to register with the charity will be sent the saliva kits. They just have to fill a questionnaire, spit into the tube and send it back. "Ultimately, this is about saving more lives. Anthony Nolan provides two potentially lifesaving transplants every ...]]> http://www.medindia.net/news/Saliva-Test-to-be-Used-for-Bone-Marrow-Matches-70744-1.htm http://www.medindia.net/news/Compulsive-Disorder-in-Mice-can-be-Cured-by-Transplanting-Bone-Marrow-69475-1.htm New research says that compulsive behaviour in mice can be cured by bone marrow transplant. The study has appeared in the May 28th issue of Cell, a Cell Press publication. The Hoxb8 gene plays an important role in the development of immune cells known as microglia, which reside in the brain. Studies in which the researchers labelled Hoxb8 cells found that they show up in the brain exclusively in bone marrow-derived microglia. When they transplanted healthy bone marrow from control ...]]> http://www.medindia.net/news/Compulsive-Disorder-in-Mice-can-be-Cured-by-Transplanting-Bone-Marrow-69475-1.htm http://www.medindia.net/news/Women-Less-Likely-to-Undergo-Bone-Marrow-Transplantation-69257-1.htm African-Americans and women are less likely than Caucasians and men to undergo Women Less Likely to Undergo Bone Marrow Transplantation to treat cancers of the blood. That is the conclusion of a new analysis published early online in ICancer/I, a peer-reviewed journal of the American Cancer Society. The study's results indicate that additional research is needed to determine why disparities exist in access to bone marrow transplantation and also that the medical community should work to eliminate these inequities....]]> http://www.medindia.net/news/Women-Less-Likely-to-Undergo-Bone-Marrow-Transplantation-69257-1.htm http://www.medindia.net/news/Multiple-Sclerosis-Patients-can-Benefit-from-Bone-Marrow-Stem-Cell-Therapy-68583-1.htm A pathbreaking trial using bone marrow stem cell therapy for multiple sclerosis (MS) patients has helped stabilise the disease, according to researchers. The research team, led by Neil Scolding, Burden Professor of Clinical Neurosciences for the University of Bristol and North Bristol NHS Trust, completed the trial in patients with MS to begin translating the findings from the laboratory to the clinic. The Bristol team report on this pioneering trial in an article published ...]]> http://www.medindia.net/news/Multiple-Sclerosis-Patients-can-Benefit-from-Bone-Marrow-Stem-Cell-Therapy-68583-1.htm http://www.medindia.net/news/Salman-Khan-Promotes-Bone-Marrow-Donation-68552-1.htm Salman Khan is known for his generosity and espousal of worthy causes. He has now taken up the issue of bone marrow donation, which is acutely needed in the country and could help treat conditions like leukemia. "Salman first got to know about the lack of bone marrow donors through a friend. He has become quite net savvy of late and did a lot of research on the topic himself," a source told the Times of India. "Compared to other countries, the situation in India is quite primitive." The source ...]]> http://www.medindia.net/news/Salman-Khan-Promotes-Bone-Marrow-Donation-68552-1.htm http://www.medindia.net/news/Toddler-Battling-for-Life-After-Icelands-Volcanic-Ash-Delays-Bone-Marrow-Transplant-67903-1.htm A toddler is in a critical condition in England after Iceland's volcanic ash and the disruption of flights delayed a scheduled bone marrow transplant. The girl is one of the 16 patients who are now in "critical red" condition following a delay in transplants. A spokesman for the Anthony Nolan Trust, which organized the marrow transplant said that it was a life and death situation for the girl and added that her family was going through a nerve-wracking time. The girl was due to receive a marrow ...]]> http://www.medindia.net/news/Toddler-Battling-for-Life-After-Icelands-Volcanic-Ash-Delays-Bone-Marrow-Transplant-67903-1.htm http://www.medindia.net/news/HIV-infected-Cells-can-Reside-in-the-Bone-Marrow-66190-1.htm Researchers at University of Michigan have identified a new reservoir for hidden HIV-infected cells that can serve as a factory for new infections. The findings indicate a new target for curing the disease so that those infected with the virus might not have to rely on AIDS drugs for a lifetime. "Antiviral drugs have been effective at keeping the virus at bay. However once the drug therapy is stopped, the virus comes back," Nature quoted senior author of the study Dr. Kathleen L. Collins, as saying....]]> http://www.medindia.net/news/HIV-infected-Cells-can-Reside-in-the-Bone-Marrow-66190-1.htm http://www.medindia.net/news/Aprepitant-Drug-Reduces-Nausea-Vomiting-in-Bone-Marrow-Transplant-Patients-65777-1.htm Bone marrow transplant patients say two of the most debilitating side effects of the treatment are nausea and vomiting caused by chemotherapy and radiation. But a Loyola University Health System study has found the drug aprepitant can dramatically reduce both nausea and vomiting when combined with other anti-nausea drugs. Seventy-three percent of patients receiving aprepitant experienced no vomiting during the study period, compared with 23 percent of patients who received a placebo. (Both ...]]> http://www.medindia.net/news/Aprepitant-Drug-Reduces-Nausea-Vomiting-in-Bone-Marrow-Transplant-Patients-65777-1.htm http://www.medindia.net/news/Heart-Disease-Patients-Will-Benefit-With-Bone-Marrow-Cell-Transplants-65566-1.htm Two new studies, conducted by scientists in Brazil and China, may lead to novel treatments for heart diseases. The first study, conducted by Brazilian researchers, found that cell transplantation of bone marrow mononuclear cells (BMMCs) directly into the heart benefited patients suffering from refractory angina. A separate study, carried out by researchers in the Peoples' Republic of China, found that apelin, a newly described inotropic peptide, improves heart function following transplantation of BMMCs....]]> http://www.medindia.net/news/Heart-Disease-Patients-Will-Benefit-With-Bone-Marrow-Cell-Transplants-65566-1.htm http://www.medindia.net/news/Fusing-Bone-Marrow-Cells-to-Embryonic-Stem-Cells-Could-Evade-Immune-System-Rejection-64428-1.htm A new strategy for making embryonic stem cell transplants less likely to be rejected by a recipient's immune system, by scientists from Iowa and Iran, who have used cells from mice. The strategy, involves fusing bone marrow cells to embryonic stem cells. Once fused, the hybrid cells have DNA from both the donor and recipient, raising hopes that immune rejection of embryonic stem cell therapies can be avoided without drugs. "Our study shows that transplanted bone marrow cells ...]]> http://www.medindia.net/news/Fusing-Bone-Marrow-Cells-to-Embryonic-Stem-Cells-Could-Evade-Immune-System-Rejection-64428-1.htm http://www.medindia.net/news/Bone-Marrow-Cells-are-the-Answer-to-Avoid-Rejection-64413-1.htm Scientists from Iowa and Iran have used cells from mice and have discovered a new strategy for making embryonic stem cell transplants less likely to be rejected by a recipient's immune system. This strategy, described in a new research report appearing in the February 2010 print issue of The IFASEB Journal/I (A HREF="http:www.fasebj.org"http:www.fasebj.org/A), involves fusing bone marrow cells to embryonic stem cells. Once fused, the hybrid cells have DNA from both the donor and recipient, ...]]> http://www.medindia.net/news/Bone-Marrow-Cells-are-the-Answer-to-Avoid-Rejection-64413-1.htm http://www.medindia.net/news/Bone-Marrow-Nerve-Damage-Linked-to-Blindness-causing-Diabetic-Complication-63373-1.htm Researchers say, bone marrow nerve damage has been found to play a crucial role in blindness-causing complications in diabetics. According to Julia Busik, an associate professor in MSU's Department of Physiology, the key to better treating retinopathy damage to blood vessels in the retina that affects up to 80 percent of diabetic patients - lies not in the retina but in damage to the nerves found in bone marrow that leads to the abnormal release of stem cells. "With ...]]> http://www.medindia.net/news/Bone-Marrow-Nerve-Damage-Linked-to-Blindness-causing-Diabetic-Complication-63373-1.htm http://www.medindia.net/news/Boffins-Find-That-Infusion-of-Bone-Marrow-Cells-Reduces-Chances-of-Second-Heart-Attack-62099-1.htm In a new study, researchers found that cells from heart attack survivors' own bone marrow reduced the risk of death or another heart attack when infused into the affected artery after successful stent placement. Benefits found early in the trial could last for at least two years, researchers said. "More research is needed, but this gives us a hint of what might be possible with this new treatment - prevention of another heart attack and of rehospitalization for heart failure, both life-threatening ...]]> http://www.medindia.net/news/Boffins-Find-That-Infusion-of-Bone-Marrow-Cells-Reduces-Chances-of-Second-Heart-Attack-62099-1.htm http://www.medindia.net/news/Key-to-Complications-of-Bone-Marrow-Transplantation-Lies-in-Proteins-61758-1.htm A process known as allogeneic bone marrow transplantation is the preferred treatment for a number of cancers and other medical conditions. The treatment often causes an extended period of immune deficiency, resulting in susceptibility to infections and recurrence of cancers. Damage to the thymus (the part of the body where immune cells known as T cells develop) elicited by T cells from the donor bone marrow (a medical condition known as thymic GVHD [tGVHD]) contributes to the deficit in T cell immunity....]]> http://www.medindia.net/news/Key-to-Complications-of-Bone-Marrow-Transplantation-Lies-in-Proteins-61758-1.htm http://www.medindia.net/news/Gene-Mismatch-Influences-Success-of-Bone-Marrow-Transplants-61288-1.htm A commonly inherited gene deletion can increase the likelihood of immune complications following bone marrow transplantation, an international team of researchers reports in the November 22 advance online issue of INature Genetics/I. When the gene, called UGT2B17, is missing from the donor's genome but present in the recipient's, transplants have a significantly greater risk of a serious side-effect known as graft-versus-host disease, in which immune cells from the donor attack tissues in the recipient....]]> http://www.medindia.net/news/Gene-Mismatch-Influences-Success-of-Bone-Marrow-Transplants-61288-1.htm http://www.medindia.net/news/Leukemia-Cell-Detection-is-Enhanced-by-High-sensitivity-Bone-Marrow-Aspiration-Technology-59183-1.htm A viable technology to improve the detection of leukemia cells in bone marrow has been developed by scientists. Superconducting Quantum Interference Device (SQUID) enhanced the ability to rapidly quantify the amount of nanoparticle bound tumor cells in a sample at least 10 fold, and increased sensitivity of minimal residual disease measurements. Results of this proof-of-concept study are published in ICancer Research/I, a journal of the American Association for Cancer Research. "This ...]]> http://www.medindia.net/news/Leukemia-Cell-Detection-is-Enhanced-by-High-sensitivity-Bone-Marrow-Aspiration-Technology-59183-1.htm http://www.medindia.net/news/Gene-Discovery-Could-Lead-to-New-Therapies-for-Bone-Marrow-Disease-58854-1.htm Scientists from Van Andel Research Institute (VARI) have identified a gene that helps in progression of Myelodysplastic Syndrome (MDS), a bone marrow disease. They believe that the new gene called RhoB could prove to be a therapeutic target for late-stage MDS. "Using our genetic models, we've been able to provide a better understanding of underlying molecular defects that drive the malignant progression of MDS," said VARI Distinguished Scientific Investigator Dr Art Alberts. "The genes ...]]> http://www.medindia.net/news/Gene-Discovery-Could-Lead-to-New-Therapies-for-Bone-Marrow-Disease-58854-1.htm http://www.medindia.net/news/Researchers-Identify-Potential-Risk-in-Transfusions-of-Platelets-Before-Bone-Marrow-Transplant-56288-1.htm A potential risk of transfusing donated platelets, especially to patients with bone marrow failure syndromes who are subsequently candidates for bone marrow transplantation has been identified. The results are online and scheduled for publication in the September 1 issue of the IJournal of Clinical Investigation/I. Doctors have noticed a pattern in performing bone marrow transplants as a cure for diseases involving bone marrow failure: more transfusions before a bone marrow transplant ...]]> http://www.medindia.net/news/Researchers-Identify-Potential-Risk-in-Transfusions-of-Platelets-Before-Bone-Marrow-Transplant-56288-1.htm http://www.medindia.net/news/Molecule-Helps-Breast-Cancer-Cells-to-Survive-in-the-Bone-Marrow-54260-1.htm Cases of breast cancer relapse are nothing new as patients often succumb to the disease years later when the cancer shows up in a different part of the body. Now, scientists have identified key signals that support the long term survival of breast cancer cells after they have spread to the bone marrow. The research, published by Cell Press in the July issue of the journal ICancer Cell/I, may lead to development of treatment strategies that decrease the likelihood of breast cancer recurrence in the bone and other organs....]]> http://www.medindia.net/news/Molecule-Helps-Breast-Cancer-Cells-to-Survive-in-the-Bone-Marrow-54260-1.htm http://www.medindia.net/news/Extract-From-Bone-Marrow-Is-Beneficial-To-Cardiac-Function-After-Heart-Attack-53916-1.htm An extract derived from bone marrow cells is as effective as therapy using bone marrow stem cells for improving cardiac function after a heart attack, finds a new study. The study was conducted in mice using a novel stem cell delivery method developed by researchers to show that the extract from bone marrow cells is as beneficial to cardiac function as are intact, whole cells. Both the cell and cell extract therapies resulted in the presence of more blood vessels and less cardiac cell death, or apoptosis, than no therapy....]]> http://www.medindia.net/news/Extract-From-Bone-Marrow-Is-Beneficial-To-Cardiac-Function-After-Heart-Attack-53916-1.htm http://www.medindia.net/news/Adult-Stem-Cells-from-Bone-Marrow-can-Reach-Cancer-Killing-Protein-to-Tumors-51694-1.htm Researchers in London have discovered the power of adult stem cells from bone marrow to reach cancer-killing protein to tumors. The genetically engineered stem cells are able to home to the cancer cells, both in culture and in mouse models, and deliver TNF-related apoptosis-inducing ligand (TRAIL), destroying the tumor cells while sparing normal cells. The research will be presented on Tuesday, May 19, at the American Thoracic Society's 105th International Conference in San Diego. "Present oncological ...]]> http://www.medindia.net/news/Adult-Stem-Cells-from-Bone-Marrow-can-Reach-Cancer-Killing-Protein-to-Tumors-51694-1.htm http://www.medindia.net/news/Ischemic-Heart-Disease-Patients-may-be-Helped-by-Bone-Marrow-Cell-Therapy-51680-1.htm A new study appearing in JAMA is saying that injection of bone marrow cells into the heart of patients with chronic myocardial ischemia may be associated with modest improvements in blood flow and function of the left ventricle. Bone marrow cell therapy is currently being investigated as a new therapeutic option for patients with ischemic heart disease. Two small-sized studies assessed the effect of this therapy in patients with chronic myocardial ischemia, but with varying results, according to background information in the article....]]> http://www.medindia.net/news/Ischemic-Heart-Disease-Patients-may-be-Helped-by-Bone-Marrow-Cell-Therapy-51680-1.htm http://www.medindia.net/news/Bone-Marrow-Donors-Touching-One-Million-in-China-51560-1.htm The China Marrow Donor Program (CMDP) is a resounding success, say authorities. Since its establishment in 2001, as many as 970,000 persons have responded, as of last month. "We expect the number of donors to reach 1 million next year," said Hong Junling, the CMDP director, at the program's annual meeting Tuesday. The number of donors increased by 170,000 in 2008 over the previous year, he said. He attributed the increase to more investment in collecting samples, building storages and improving test devices....]]> http://www.medindia.net/news/Bone-Marrow-Donors-Touching-One-Million-in-China-51560-1.htm http://www.medindia.net/news/Revolutionary-Treatment-to-Obtain-Bone-Marrow-From-Stem-Cells-on-the-Anvil-50154-1.htm Researchers at Universiti de Montrial have successfully produced a large quantity of laboratory stem cells from a small number of blood stem cells obtained from bone marrow. The research team, led by Dr. Guy Sauvageau, has taken a giant step towards the development of a revolutionary treatment based on these stem cells. It is known that a bone marrow stem cell transplant can reconstitute the recipient's bone marrow. The main difficulty is to obtain a sufficient number of compatible stem cells....]]> http://www.medindia.net/news/Revolutionary-Treatment-to-Obtain-Bone-Marrow-From-Stem-Cells-on-the-Anvil-50154-1.htm http://www.medindia.net/news/Researchers-Use-Stem-Cells-From-Bone-Marrow-To-Grow-Blood-Vessels-49675-1.htm Researchers have grown new blood vessels using stem cells from bone marrow, a medical advance that could be used to treat patients with diseases such as peripheral artery disease. It's one of the severe complications often faced by people who've had diabetes for a long time. Reduced blood flow (ischemia) in their limbs can lead to resting pain, trouble with wound healing and in severe cases, amputation. During the research, David Hess of the Robarts Research Institute at the university ...]]> http://www.medindia.net/news/Researchers-Use-Stem-Cells-From-Bone-Marrow-To-Grow-Blood-Vessels-49675-1.htm http://www.medindia.net/news/Patients-Own-Bone-Marrow-Stem-Cells-May-Help-Treat-Heart-Attack-49407-1.htm Patients treated with their own bone marrow stem cells after a heart attack experienced increased circulation within the heart, a study by Emory University School of Medicine physicians has found. Principal investigator Arshed Quyyumi, MD, professor of medicine at Emory University School of Medicine, presents the results Monday at the American College of Cardiology conference in Orlando. "These results show that treatment with a patient's own bone marrow stem cells has the potential to reduce ...]]> http://www.medindia.net/news/Patients-Own-Bone-Marrow-Stem-Cells-May-Help-Treat-Heart-Attack-49407-1.htm http://www.medindia.net/news/Bone-Marrow-Stem-Cell-Injections-may-Help-Treat-Spinal-Cord-Injury-48652-1.htm Injecting a patient's own bone marrow-derived stem cells into the spinal column using multiple routes can be an effective treatment for spinal cord injury (SCI), say researchers. Scientists from DaVinci Biosciences, Costa Mesa, California, and Hospital Luis Vernaza in Ecuador say that such a treatment can return some quality of life for SCI patients without serious adverse events. Revealing their findings in the journal Cell Transplantation, the researchers said that they administered bone ...]]> http://www.medindia.net/news/Bone-Marrow-Stem-Cell-Injections-may-Help-Treat-Spinal-Cord-Injury-48652-1.htm http://www.medindia.net/news/Diabetics-May-Soon-Turn-to-Bone-Marrow-Transplantation-to-Restore-Nerve-Sensation-47260-1.htm In a recent successful study, Emory University researchers restored nerve function in diabetic mice. The process they adopted - bone marrow cell transplantation. The team revealed that transplanting cells that replenish blood vessels could restore nerve function in an animal model of diabetic neuropathy. The majority of people with diabetes have some form of neuropathy-damage to the peripheral nerves that can cause a loss of sensation in hands, arms, feet or legs. The damage, caused ...]]> http://www.medindia.net/news/Diabetics-May-Soon-Turn-to-Bone-Marrow-Transplantation-to-Restore-Nerve-Sensation-47260-1.htm