http://www.medindia.net/healthnews/Clinical-Trials-Different-Phases-news.asp Medindia largest health website in india. en-us Copyright 2013. All Rights Reserved. Tue, 21 May 2013 02:09:05 GMT http://www.medindia.net/news/new-drug-enhances-radiation-treatment-for-brain-cancer-118936-1.htm A novel drug may significantly help increase the effectiveness of radiation therapy for the most deadly form of brain cancer, say scientists at Virginia Commonwealth University Massey Cancer Center. In mouse models of human glioblastoma multiforme (GBM), the new drug helped extend survival to a great extent when used in combination with radiation therapy. Recently published in the journal iClinical Cancer Research/i, the study provides the first preclinical evidence demonstrating that an ATM kinase inhibitor radiosensitizes gliomas....]]> http://www.medindia.net/news/new-drug-enhances-radiation-treatment-for-brain-cancer-118936-1.htm http://www.medindia.net/news/early-predictors-of-disease-progression-which-could-speed-huntingtons-disease-drug-trials-identified-118775-1.htm A set of tests that could help identify whether and how Huntington's disease (HD) is progressing in groups of people who are not yet showing symptoms were identified by scientists. The latest findings from the TRACK-HD study*, published Online First in iThe Lancet Neurology/i, could be used to assess whether potential new treatments are slowing the disease up to 10 years before the development of noticeable symptoms.br / br /"Currently, the effectiveness of a new drug is decided by its ability to treat symptoms....]]> http://www.medindia.net/news/early-predictors-of-disease-progression-which-could-speed-huntingtons-disease-drug-trials-identified-118775-1.htm http://www.medindia.net/news/new-drug-can-reduce-amount-of-alcohol-consumed-by-problem-drinkers-118514-1.htm There may be relief at hand for Britons suffering from alcoholism with a new drug, which helps them reduce the amount of alcohol they consume, to be available from Monday. The drug, known as nalmefene, has already been approved in Norway, Finland, Poland and the Baltic countries and doctors in Britain can now prescribe the drug to their patients with the manufacturers claiming that it can reduce the alcohol consumption levels by as much as 60 percent. The drug will cost around 42.42 for 14 tablets....]]> http://www.medindia.net/news/new-drug-can-reduce-amount-of-alcohol-consumed-by-problem-drinkers-118514-1.htm http://www.medindia.net/news/us-doctor-creates-new-website-that-made-clinical-trials-easy-to-find-118320-1.htm A website is being created by a US doctor to make it easier for sick people to connect with research that could potentially save their lives. The non-profit endeavor known as MyClinicalTrialLocator.com aims to become "the Wikipedia of clinical trials," by allowing a quick and free search for studies at academic centers around the globe, said its founder Bruce Moskowitz. It also seeks to provide an easier experience than the US government-run website ClinicalTrials.gov, which critics say ...]]> http://www.medindia.net/news/us-doctor-creates-new-website-that-made-clinical-trials-easy-to-find-118320-1.htm http://www.medindia.net/news/results-of-first-american-clinical-trial-for-stem-cell-based-treatment-of-als-encourages-researchers-118271-1.htm Researchers completed the first American clinical trial involving stem cell-based treatment of Amyotrophic Lateral Sclerosis (ALS). They were encouraged by the trial study's results, noting that this delivery approach could be a helpful therapeutic approach for other traumatic spine-related problems. The group focused on the safety of a direct microinjection-based technique and neural stem cell transplantation to the cervical and thoracolumbar spinal cord. Eighteen microinjection procedures ...]]> http://www.medindia.net/news/results-of-first-american-clinical-trial-for-stem-cell-based-treatment-of-als-encourages-researchers-118271-1.htm http://www.medindia.net/news/esperion-therapeutics-has-raised-33-million-to-finance-clinical-trials-117975-1.htm American biotech company Esperion Therapeutics revealed that it has managed to raise (Dollor) 33 million through preferred stock financing which will be used on clinical trials. The Ann Arbor based company is currently in midst of the phase II trial of LDL-lowering pill, ETC-1002, which it says will be able to reduce levels of bad cholesterol by as much as 43 percent. The CEO of the company, Tim Mayleben said that the money generated will be used on the trials, adding that they expect to publish the results of the trial by June....]]> http://www.medindia.net/news/esperion-therapeutics-has-raised-33-million-to-finance-clinical-trials-117975-1.htm http://www.medindia.net/news/new-technology-shows-promise-for-reinventing-drug-discovery-117824-1.htm Harvard Stem Cell Institute (HSCI) researchers have found a compound more effective in protecting the neurons killed in amyotrophic lateral sclerosis (ALS) than two drugs that failed in human clinical trials after hundreds of millions of dollars had been invested in them. The researchers made this discovery by using a new stem-cell based drug screening technology. The new stem cell screening technique developed by Lee Rubin, a member of HSCI's Executive Committee and a professor in Harvard's ...]]> http://www.medindia.net/news/new-technology-shows-promise-for-reinventing-drug-discovery-117824-1.htm http://www.medindia.net/news/researchers-suggest-new-drug-combination-therapy-to-treat-leukemia-117734-1.htm A new, pre-clinical study by researchers suggests that a novel drug combination could lead to profound leukemia cell death by disrupting the function of two major pro-survival proteins. The study took place at Virginia Commonwealth University Massey Cancer Center. The effectiveness of the therapy lies in its ability to target a pro-survival cell signaling pathway known as PI3K/AKT/mTOR, upon which the leukemia cells have become dependent. In the study, published in the journal iCancer ...]]> http://www.medindia.net/news/researchers-suggest-new-drug-combination-therapy-to-treat-leukemia-117734-1.htm http://www.medindia.net/news/new-class-of-cancer-drugs-safe-and-effective-found-by-tgen-scottsdale-healthcare-clinical-trial-117428-1.htm The Scottsdale Healthcare's Virginia G. Piper Cancer Center Clinical Trials and the Translational Genomics Research Institute (TGen) reported the safety and preliminary efficacy of a new class of tumor fighting drugs. Early results from the phase I, first in-human study of an RNA interference (RNAi) drug were announced during the American Association for Cancer Research (AACR) Annual Meeting 2013, April 6-10, in Washington, D.C. The drug, TKM-080301 (also known as TKM-PLK1) is being developed by Tekmira Pharmaceuticals Corporation....]]> http://www.medindia.net/news/new-class-of-cancer-drugs-safe-and-effective-found-by-tgen-scottsdale-healthcare-clinical-trial-117428-1.htm http://www.medindia.net/news/phase-1-clinical-trial-reveals-positive-data-for-bind-theraputics-drug-for-solid-tumors-117315-1.htm Presenting the data at the American Association for Cancer Research (AACR) 2013 Annual Meeting, biopharmaceutical company BIND Therapeutics revealed that phase 1 clinical data for BIND-014, the company's leading drug candidate, have been positive. Clinical investigators presented the Phase 1 results with BIND-014, its targeted docetaxel Accurin, in 28 heavily-pretreated patients with advanced or metastatic solid tumors. In the study, BIND-014 was shown to be generally safe and well-tolerated ...]]> http://www.medindia.net/news/phase-1-clinical-trial-reveals-positive-data-for-bind-theraputics-drug-for-solid-tumors-117315-1.htm http://www.medindia.net/news/new-drug-target-for-metastatic-breast-cancer-identified-117297-1.htm Tumor suppressor genes work to inhibit the growth and spread of breast cancer cells to the lungs, say researchers. The research is published this week online in the iJournal of Biological Chemistry/i. Working in a mouse model, the LSUHSC research team studied LKB1, an enzyme that functions as a tumor suppressor in the small intestine, and Nischarin, a novel protein that regulates breast cancer cell migration and movement discovered by Dr. Alahari in 2000. Thirty percent of lung ...]]> http://www.medindia.net/news/new-drug-target-for-metastatic-breast-cancer-identified-117297-1.htm http://www.medindia.net/news/new-drug-options-to-target-genetic-vulnerability-of-lung-cancer-116965-1.htm A vulnerability of certain lung cancer cells that can be exploited for new therapies has been identified by physician-researchers at UT Southwestern Medical Center. Although researchers have long known that mutant versions of the KRAS gene drive tumor formation and are key to cell survival in non-small cell lung cancer, the blocking of activated KRAS has proven difficult. For years, investigations have explored stopping lung cancer at this junction, which also would have an impact on many other cancers....]]> http://www.medindia.net/news/new-drug-options-to-target-genetic-vulnerability-of-lung-cancer-116965-1.htm http://www.medindia.net/news/new-drug-to-treat-lung-cancer-in-patients-116533-1.htm A new drug that impairs the function of cancer-driving proteins may prove to be a new treatment for patients with lung cancer. The drug, ganetespib, may also be effective for treating patients who have become resistant to the only FDA-approved targeted therapy for this disease, crizotinib, according to data published in iCancer Discovery/i, a journal of the American Association for Cancer Research. "Lung cancer, a leading cause of death, is no longer thought of as a single disease, ...]]> http://www.medindia.net/news/new-drug-to-treat-lung-cancer-in-patients-116533-1.htm http://www.medindia.net/news/clinical-trial-shows-how-shock-treatments-can-kill-children-115793-1.htm In East Africa, the results from the Fluid Expansion as Supportive Therapy (FEAST) trial show that children who are given fluid to treat shock have an increased risk of death. Death occured due to cardiovascular collapse at 48 hours. These findings in BioMed Central's open access journal iBMC Medicine/i challenge the generally held idea that early and rapid reversal of shock by fluid resuscitation translates into longer-term survival benefits. The FEAST trial was conducted in six African ...]]> http://www.medindia.net/news/clinical-trial-shows-how-shock-treatments-can-kill-children-115793-1.htm http://www.medindia.net/news/436-clinical-trial-deaths-in-india-last-year-115711-1.htm The Indian parliament was told on Tuesday that a total of 436 deaths were recorded during clinical trials in India in 2012. While 438 deaths took place during clinical trials in 2011, 668 people died during 2010, Health Minister Ghulam Nabi Azad said told the Rajya Sabha in reply to a question. Out of the 436 deaths in 2012, 16 were caused due to the clinical trials, he said. Rest of the deaths might have been disease-related in the cases of terminally ill patients suffering from cancer, ...]]> http://www.medindia.net/news/436-clinical-trial-deaths-in-india-last-year-115711-1.htm http://www.medindia.net/news/relapse-risk-does-not-reduce-if-common-ms-drugs-are-taken-together-clinical-trial-115663-1.htm Interferon (and) #946;-1a (INF) and glatiramer acetate (GA), two of the most commonly prescribed drugs for multiple sclerosis (MS), provide no additional clinical benefit when taken together finds a recent clinical trial. While findings published today in iAnnals of Neurology/i, a journal of the American Neurological Association and Child Neurology Society, suggest that taking both INF and GA together was not superior to GA monotherapy in reducing relapse risk; the combination therapy does appear ...]]> http://www.medindia.net/news/relapse-risk-does-not-reduce-if-common-ms-drugs-are-taken-together-clinical-trial-115663-1.htm http://www.medindia.net/news/new-drug-reduces-heart-damage-during-surgery-115632-1.htm A single dose of an anti-inflammatory treatment was found to reduce heart muscle damage during angioplasty procedures, says study. The antibody inclacumab, developed by Swiss lab Hoffmann-La Roche, significantly reduced levels of the standard molecular markers troponin I and CK-MB in patients, compared to those who took a placebo in a clinical trial. Patients who received the inclacumab dose saw troponin I levels drop 22.4 percent more after 16 hours and 24.4 percent after more at 24 hours (p=0....]]> http://www.medindia.net/news/new-drug-reduces-heart-damage-during-surgery-115632-1.htm http://www.medindia.net/news/heart-damage-reduced-significantly-by-a-new-drug-under-clinical-trial-115629-1.htm A new drug, inclacumab, developed by Swiss lab Hoffmann-La Roche, showed significant results in the phase II clinical trial in reducing the levels of inflammatory enzymes that mark heart damage. Most often, heart tissue is inflamed following angioplasty and an increase in the proteins, troponin I and CK-MB are noticed. Inclacumab is designed to reduce the levels of these biomarkers thereby reducing heart damage. The trial involved 530 heart patients with an average age of 61 years and who ...]]> http://www.medindia.net/news/heart-damage-reduced-significantly-by-a-new-drug-under-clinical-trial-115629-1.htm http://www.medindia.net/news/report-patients-with-post-acs-depression-benefitted-from-active-treatment-in-clinical-trial-115602-1.htm According to a report, a clinical trial of patients with post-acute coronary syndrome (ACS, heart disease) depression finds that a centralized, patient-preference program decreased depressive symptoms and may be cost-neutral over time. The report was published Online First by iJAMA Internal Medicine/i, a JAMA Network publication. The study is being released early to coincide with its presentation at the American College of Cardiology's annual Scientific Sessions. About 1.2 million Americans ...]]> http://www.medindia.net/news/report-patients-with-post-acs-depression-benefitted-from-active-treatment-in-clinical-trial-115602-1.htm http://www.medindia.net/news/new-drug-with-vitamin-b-and-folate-may-aid-migraine-sufferers-115570-1.htm A team of researchers is well on their way to find a cure for the worst form of headache-Migraine! Migraine is not new to us. One of Lewis Carrol's character in his classic 'Alice in Wonderland' shows signs of experiencing what we now know as 'aura' an experience that is linked to migraine. A scientific team from Queensland is hoping to find a cure for migraine with a treatment involving vitamin B and folate supplements. According to Bridget Maher, postdoctoral ...]]> http://www.medindia.net/news/new-drug-with-vitamin-b-and-folate-may-aid-migraine-sufferers-115570-1.htm http://www.medindia.net/news/india-reports-six-cases-of-clinical-trial-irregularities-115361-1.htm The parliament was informed that India has reported six cases of alleged irregularities in conduct of clinical trials during the last two years. Listing steps to contain the irregularities, Health Minister Ghulam Nabi Azad told the Rajya Sabha that 12 new drug advisory committees consisting of leading experts from government medical colleges and institutes from across the country have been constituted to advise the Central Drugs Standard Control Organisation (CDSCO) in matters related to approval of clinical trials and new drugs....]]> http://www.medindia.net/news/india-reports-six-cases-of-clinical-trial-irregularities-115361-1.htm http://www.medindia.net/news/new-drug-fights-diabetes-115332-1.htm A simple once-a-day injection could offer hope to millions of people with diabetes, say researchers. The ground-breaking drug - a longer-lasting type of insulin - costs just 2.20-pound-a-day, the Daily Express reported. In order to keep their problems under control, many diabetic patients inject themselves with insulin several times a day to keep their blood sugar level steady. But the new drug called Tresiba, developed by Novo Nordisk, can revolutionise the drug industry by making ...]]> http://www.medindia.net/news/new-drug-fights-diabetes-115332-1.htm http://www.medindia.net/news/new-drug-options-for-serious-diseases-possible-via-new-discovery-115290-1.htm The way in which oxidative stress can turn to the dark side a cellular protein and make it become a powerful accomplice in neuronal death has been identified by researchers. This finding, reported today in iProceedings of the National Academy of Sciences/i, could ultimately lead to new therapeutic approaches to many of the world's debilitating or fatal diseases. The research explains how one form of oxidative stress called tyrosine nitration can lead to cell death. Through the common ...]]> http://www.medindia.net/news/new-drug-options-for-serious-diseases-possible-via-new-discovery-115290-1.htm http://www.medindia.net/news/animas-reveals-results-of-its-clinical-trial-into-closed-loop-insulin-delivery-system-115213-1.htm Presenting the results of its second phase of human clinical trials at the Advanced Technologies (and) Treatments for Diabetes (ATTD) Conference in Paris, Animas Corporation revealed that its first-generation closed loop insulin delivery system has displayed positive results in predicting the rise of fall in blood glucose and correspondingly increase, decrease, suspend and resume insulin delivery. The feasibility study of the predictive Hypoglycemia-Hyperglycemia Minimizer (HHM) System* in development ...]]> http://www.medindia.net/news/animas-reveals-results-of-its-clinical-trial-into-closed-loop-insulin-delivery-system-115213-1.htm http://www.medindia.net/news/london-university-invites-students-to-participate-in-a-clinical-trial-of-cocaine-114856-1.htm We all do know that use of cocaine is associated with adverse effects on the body. To understand completely what cocaine can do to the body, A London University has invited students to participate in a clinical trial of cocaine. Many hundreds of students have been invited by Kings College London to participate in a study which will involve nasal administration of cocaine. "After cocaine administration, repeated biological samples (blood, urine, hair, sweat, oral fluid) will be taken to ...]]> http://www.medindia.net/news/london-university-invites-students-to-participate-in-a-clinical-trial-of-cocaine-114856-1.htm http://www.medindia.net/news/new-drug-combo-could-prevent-head-and-neck-cancer-in-high-risk-patients-114615-1.htm Research findings reveal a new drug combination that could reduce the risk for patients with advanced oral precancerous lesions to develop squamous cell carcinoma of the head and neck. The results of the study, which included preclinical and clinical analyses, were published in iClinical Cancer Research/i, a journal of the American Association for Cancer Research. "Squamous cell carcinoma of the head and neck (SCCHN) is the most common type of head and neck cancer," said Dong Moon Shin, M....]]> http://www.medindia.net/news/new-drug-combo-could-prevent-head-and-neck-cancer-in-high-risk-patients-114615-1.htm http://www.medindia.net/news/new-drug-could-prevent-liver-damage-in-alcoholics-114511-1.htm Liver damage is one of the most common problems associated with regular consumption of alcohol but a team of American researchers could have found a solution to the problem, a new study published in the journal Nature Nanotechnology reveals. According to the study, researchers at University of California have developed a pill that lowers the blood alcohol concentration (BAC), thereby preventing excess damage to the liver. The researchers conducted their study on a group of mice and found that ...]]> http://www.medindia.net/news/new-drug-could-prevent-liver-damage-in-alcoholics-114511-1.htm http://www.medindia.net/news/research-details-new-way-of-looking-at-drug-discovery-114506-1.htm New developments are urgently needed in the field of drug discovery. Garret FitzGerald, MD, FRS, chair of the Department of Pharmacology and Director of the Institute for Translational Medicine (and) Therapeutics, Perelman School of Medicine at the University of Pennsylvania, has long said the current drug-development system in the United States is in need of change, "representing an unsustainable model." Even though the number of drugs approved has risen in the last three years, overall, roughly ...]]> http://www.medindia.net/news/research-details-new-way-of-looking-at-drug-discovery-114506-1.htm http://www.medindia.net/news/new-drug-to-treat-low-grade-ovarian-cancer-found-114339-1.htm Researchers have discovered that taking a regular dose of the compound selumetinib help stabilize or shrink tumors in women with low-grade serous carcinoma of the ovary or peritoneum. The findings show that selumetinib targets a mutation in the MAPK pathway for patients with low-grade serous carcinoma, allowing for treatment on previously chemoresistant tumors. "This is a potentially important breakthrough for the Gynecologic Oncology Group," said John Farley, MD, a gynecologic oncologist ...]]> http://www.medindia.net/news/new-drug-to-treat-low-grade-ovarian-cancer-found-114339-1.htm http://www.medindia.net/news/scientists-make-a-breakthrough-with-new-drug-combo-which-can-destroy-root-of-breast-cancer-cells-114052-1.htm Scientists have used a combination of drugs to target cancer stem cells that cause the disease to spread. This had led to a breakthrough in the battle against breast cancer. Current treatments kill only the surface cells in a breast tumour, but scientists now say they can destroy the root, the Mirror reported. They hope that the findings, revealed ahead of World Cancer Day, can be used to help women with advanced and aggressive cancers. Targeting cancer stem cells takes us a step closer ...]]> http://www.medindia.net/news/scientists-make-a-breakthrough-with-new-drug-combo-which-can-destroy-root-of-breast-cancer-cells-114052-1.htm http://www.medindia.net/news/scientists-develop-new-drug-to-increase-wakefulness-113850-1.htm Poor impulse control contributes to one's inability to control the consumption of rewarding substances like alcohol, food and other drugs. This can lead to the development of addiction. FDA-approved medications for alcoholism, like naltrexone (Revia) and disulfiram (Antabuse), are thought to reduce alcohol consumption by curbing cravings and creating unpleasant reactions to alcohol, effects which reduce the desire to drink alcohol. New medications, however, might target the uncontrollable urges to consume drugs of abuse....]]> http://www.medindia.net/news/scientists-develop-new-drug-to-increase-wakefulness-113850-1.htm http://www.medindia.net/news/clinical-trial-to-treat-chronic-pulmonary-sarcoidosis-launched-by-mount-sinai-113766-1.htm The first clinical trial to investigate the efficacy of immunological therapy for chronic pulmonary sarcoidosis is currently enrolling patients. The trial is being conducted by researchers at the Icahn School of Medicine at Mount Sinai. Mount Sinai has the largest Sarcoidosis Service in the world and is one of only two institutions in the country participating in the trial; the other is the University of Cincinnati. Mount Sinai is a National Institutes of Health Center of Excellence for research in sarcoidosis....]]> http://www.medindia.net/news/clinical-trial-to-treat-chronic-pulmonary-sarcoidosis-launched-by-mount-sinai-113766-1.htm http://www.medindia.net/news/publishing-information-from-clinical-trials-needs-greater-transparency-113735-1.htm According to the Editors of iPLOS Medicine/i an initiative from the drugs regulator, the European Medicines Agency, to commit to releasing all of the information from clinical trials once the marketing authorization process has ended, which has been greeted with cautious optimism by proponents of access to data but with much less enthusiasm by the pharmaceutical industry, sparks an interesting debate on the role of medical journals in publishing drug data. Writing in an Editorial, the Editors ...]]> http://www.medindia.net/news/publishing-information-from-clinical-trials-needs-greater-transparency-113735-1.htm http://www.medindia.net/news/study-identifies-new-drug-target-for-treating-alzheimers-ms-113707-1.htm Researchers have found that the protein Klotho plays an important role in the health of myelin, the insulating material allowing for the rapid communication between nerve cells. These findings may lead to new therapies for multiple sclerosis (MS) and Alzheimer's disease (AD), in which white matter abnormalities are also common but have been largely ignored. MS is an inflammatory disease, which damages the fatty myelin sheaths around the axons of the brain and spinal cord. This destruction, ...]]> http://www.medindia.net/news/study-identifies-new-drug-target-for-treating-alzheimers-ms-113707-1.htm http://www.medindia.net/news/new-drug-to-combat-auto-immune-diseases-report-113698-1.htm A newly-developed drug could kill rebellious immune cells. These cells which prey on the tissues instead of defending them, cause auto-immune diseases such as type-1 diabetes, rheumatoid arthritis and lupus. The absence of two proteins Bax and Bak from certain immune cells permits them to override apoptosis, a process that ensures cellular death after they have outlived their utility. Consequently, these cells turn against the body, with adverse health outcomes. Lorraine O'Reilly from Australia's ...]]> http://www.medindia.net/news/new-drug-to-combat-auto-immune-diseases-report-113698-1.htm http://www.medindia.net/news/clinical-trials-with-nonblinded-outcome-assessors-have-high-observer-bias-new-study-113593-1.htm Significant observer bias toward a more beneficial treatment effect in nonblinded trials when the researcher knew the treatment being given to the participant was found by a new study of randomized clinical trials. The study is published in iCMAJ/i (iCanadian Medical Association Journal/i). "Nonblinded assessors of subjective measurement scales outcomes in randomized clinical trials tended to generate substantially biased effect sizes," writes Dr. Asbjrn Hrobjartsson, The Nordic Cochrane ...]]> http://www.medindia.net/news/clinical-trials-with-nonblinded-outcome-assessors-have-high-observer-bias-new-study-113593-1.htm http://www.medindia.net/news/protection-against-side-effects-of-chemotherapy-provided-by-new-drug-113336-1.htm Protection against the side effects of cancer treatments while strengthening the effects on the tumour provided by a new drug developed at Linkoping University in Sweden. An international drug evaluation is now starting up on a larger group of patients. The results of the studies with the compound, known as calmangafodipir, were published in the latest issue of the cancer journal iTranslational Oncology/i with Professor Rolf G. G. Andersson as the main author. The research was initiated ...]]> http://www.medindia.net/news/protection-against-side-effects-of-chemotherapy-provided-by-new-drug-113336-1.htm http://www.medindia.net/news/new-drug-slows-rheumatoid-arthritis-joint-damage-113313-1.htm In rheumatoid arthritis patients, tofacitinib - a novel oral medication was found to inhibit the progression of joint damage, show clinical trial results. Results of the 12-month interim analysis of the efficacy of tofacitinib appear in iArthritis (and) Rheumatism/i, a journal published by Wiley on behalf of the American College of Rheumatology (ACR). RA is a chronic, autoimmune disease that causes inflammation, pain and swelling of the joints. Over time, RA may destroy joints, impair ...]]> http://www.medindia.net/news/new-drug-slows-rheumatoid-arthritis-joint-damage-113313-1.htm http://www.medindia.net/news/new-drug-can-target-hard-to-reach-leukemia-stem-cells-113088-1.htm A novel stem cell targeting drug that is currently under development may be able to affect hard-to-reach drug resistant leukemia stem cells, researchers at University of California, San Diego School of Medicine revealed. The findings, published in the January 17 online issue of iCell Stem Cell/i, open the possibility that diseases like chronic myeloid leukemia (CML) and some solid tumor cancers might - in combination with other therapies - be more effectively treated with this drug, and with a lower chance of relapse....]]> http://www.medindia.net/news/new-drug-can-target-hard-to-reach-leukemia-stem-cells-113088-1.htm http://www.medindia.net/news/new-congress-should-take-immediate-action-to-expand-medical-research-112775-1.htm A majority of Americans (72%) say the new Congress and the President should take action to expand medical research within the first 100 days of the 113th Congress. America Speaks, Volume 13, a compilation of public opinion polls commissioned by Research!America, features timely data about Americans' views on issues related to biomedical and health research. Public support for increased government spending on medical research holds particular relevance as Congress considers whether to further ...]]> http://www.medindia.net/news/new-congress-should-take-immediate-action-to-expand-medical-research-112775-1.htm http://www.medindia.net/news/supreme-court-orders-health-ministry-to-monitor-new-applications-for-clinical-trials-in-india-112414-1.htm The health ministry was ordered by the Supreme Court of India to ensure that any new applications for clinical trials of new drugs were monitored closely with the apex court stating that unregulated clinical trials were creating "havoc" in the country. The comments were made during a hearing on a petition detailing deaths and health problems caused by clinical trials carried out on Indians, often without their knowledge or consent. "Uncontrolled clinical trials are causing havoc to human life," Justice R....]]> http://www.medindia.net/news/supreme-court-orders-health-ministry-to-monitor-new-applications-for-clinical-trials-in-india-112414-1.htm http://www.medindia.net/news/new-method-could-help-manufacturers-predict-side-effects-of-a-new-drug-112364-1.htm Researchers have developed a new method that could help drug manufacturers better predict the side effects that a patient may experience by taking a drug, a new study published in the Journal of Chemical Information and Modeling reveals. Yoshihiro Yamanishi and colleagues explain that drug side effects are a major health problem - the fourth-leading cause of death in the U.S. - which by some estimates claim 100,000 lives every year. Serious side effects are the main reason why existing drugs ...]]> http://www.medindia.net/news/new-method-could-help-manufacturers-predict-side-effects-of-a-new-drug-112364-1.htm http://www.medindia.net/news/aiming-to-make-several-types-of-cancer-self-destruct-is-a-new-drug-112032-1.htm Poised to test whether new drugs can work against a wide range of cancers independently of where they originated - breast, prostate, liver, lung for the first time ever are three pharmaceutical companies. The drugs go after an aberration involving a cancer gene fundamental to tumour growth, the New York Times reported. Many scientists see this as the beginning of a new genetic age in cancer research. Even though great uncertainties remain, such drugs could mean new treatments for rare, neglected cancers, as well as common ones....]]> http://www.medindia.net/news/aiming-to-make-several-types-of-cancer-self-destruct-is-a-new-drug-112032-1.htm http://www.medindia.net/news/gene-therapy-cocktail-shows-promise-in-long-term-clinical-trial-111888-1.htm Clinical trial result shows that a gene therapy cocktail conveyed into the brain by a molecular special delivery vehicle may help extend the lives of children with Canavan disease. It is a rare and fatal neurodegenerative disorder. A report of the trial appears in the Dec. 19, 2012 online edition of the journal iScience Translational Medicine/i. The form of gene therapy was created and developed at the University of North Carolina School of Medicine. The work was spearheaded by R....]]> http://www.medindia.net/news/gene-therapy-cocktail-shows-promise-in-long-term-clinical-trial-111888-1.htm http://www.medindia.net/news/cognitive-test-used-in-alzheimers-drug-trial-flawed-111667-1.htm A number of clinical trials related to drug development for Alzheimer's disease have been called into question after researchers at Plymouth University Peninsula Schools of Medicine and Dentistry said that the cognitive test used in such trials is flawed. The current standard cognitive test for the disease is the ADAS Cog. The new research, published as two studies in iAlzheimer's (and) Dementia/ii: The Journal of the Alzheimer's Association/i, investigates the role of the test and questions its effectiveness....]]> http://www.medindia.net/news/cognitive-test-used-in-alzheimers-drug-trial-flawed-111667-1.htm http://www.medindia.net/news/automated-design-helps-in-new-drug-discovery-111513-1.htm For new drugs, a system of 'automated design' could help develop the complex therapies needed for many medical conditions while also improving drug safety and efficiency. This was shown by a new research from the University of Dundee. The 'Moneyball' approach taken by the research team utilises the principles of advanced statistical and data analysis which have seen to be increasingly influential in areas as varied as sport, finance and in forecasting the recent US Presidential election....]]> http://www.medindia.net/news/automated-design-helps-in-new-drug-discovery-111513-1.htm http://www.medindia.net/news/experimental-agent-briefly-eases-depression-rapidly-in-test-clinical-trial-111493-1.htm According to a clinical trial conducted by the National Institutes of Health, a drug that works through the same brain mechanism as the fast-acting antidepressant ketamine briefly improved treatment-resistant patients' depression symptoms in minutes, with minimal untoward side effects. The experimental agent, called AZD6765, acts through the brain's glutamate chemical messenger system. Existing antidepressants available through prescription, which work through the brain's serotonin system, ...]]> http://www.medindia.net/news/experimental-agent-briefly-eases-depression-rapidly-in-test-clinical-trial-111493-1.htm http://www.medindia.net/news/new-drug-for-duchenne-muscular-dystrophy-in-the-offing-111466-1.htm Researchers are currently testing new drugs that show promise in treating patients with Duchenne muscular dystrophy (DMD). The inherited disease affects about one in 3,600 boys and results in muscle degeneration and, eventually, death. Now, scientists at UCLA have found a drug, already approved by the U.S. Food (and) Drug Administration and being used in humans, that provides a powerful boost to the therapy currently being tested in clinical trials. They hope this one-two punch used in combination ...]]> http://www.medindia.net/news/new-drug-for-duchenne-muscular-dystrophy-in-the-offing-111466-1.htm http://www.medindia.net/news/positive-early-results-shown-in-clinical-trial-for-dna-vaccine-111342-1.htm Robust vaccine-specific antibody responses in all vaccinated patients evaluated to date were shown in the early results of a trial to treat leukaemia with a WT1 DNA vaccine. Furthermore, T cell immune responses, including those of the "killer T cells," were detected. Antibody and T cell responses are strong signals of the DNA vaccine's potential to treat the disease. Presented at the DNA Vaccines 2012 conference in California by Christian Ottensmeier, the trial's principal investigator ...]]> http://www.medindia.net/news/positive-early-results-shown-in-clinical-trial-for-dna-vaccine-111342-1.htm http://www.medindia.net/news/new-drug-found-effective-against-prostate-cancer-111099-1.htm A new drug, cabozantinib, produced dramatic and rapid effect on prostate cancer that had spread to the bone, according to an American study. About two-thirds of patients treated with the drug showed improvements on their bone scans. These bone scans assess the degree to which cancer is in the bone. Improvements on these scans suggest a response to the drug. "The effects of cabozantinib on bone scans are unprecedented in the treatment of prostate cancer," says David C. Smith, professor of ...]]> http://www.medindia.net/news/new-drug-found-effective-against-prostate-cancer-111099-1.htm