http://www.medindia.net/healthnews/Clinical-Trials-Different-Phases-news.asp Medindia largest health website in india. en-us Copyright 2012. All Rights Reserved. Fri, 25 May 2012 05:05:21 GMT http://www.medindia.net/news/heat-shock-protein-inhibitor-and-hormonal-therapy-combo-tested-in-breast-cancer-clinical-trial-101624-1.htm Pushed to the edge of survival, the hyper-driven cells of a cancerous tumor tap into an ancient system that has helped organisms cope with internal stresses and environmental challenges since life began. Most importantly in this system, heat shock protein 90 (HSP90) has been shown to help malignant cells accommodate the genetic changes and profound disturbances in normal biology that occur in cancers. Researchers have theorized that inhibiting HSP90 just might render breast cancer cells less ...]]> http://www.medindia.net/news/heat-shock-protein-inhibitor-and-hormonal-therapy-combo-tested-in-breast-cancer-clinical-trial-101624-1.htm http://www.medindia.net/news/verify-clinical-trials-of-non-skeletal-benefits-of-vitamin-d-demand-experts-101600-1.htm New scientific statement on representation of the first comprehensive evaluation of both the basic and clinical evidence linked to the non-skeletal effects of vitamin D published online by The Endocrine Society. The statement addresses current research regarding the associations of vitamin D with immune function, hypertension, stroke, skin conditions and maternal/fetal health. Vitamin D is a steroid hormone that regulates calcium and phosphate levels in the bloodstream and promotes healthy bone growth....]]> http://www.medindia.net/news/verify-clinical-trials-of-non-skeletal-benefits-of-vitamin-d-demand-experts-101600-1.htm http://www.medindia.net/news/clinical-trials-into-new-drug-targeting-abnormal-genes-responsible-for-cancer-provides-encouraging-results-in-phase-i-trial-101572-1.htm Clinical trials testing out a new drug, which targets abnormal genes that are responsible for specific cancers, have given encouraging signs to researchers who are testing the drugs in children suffering from a rare and aggressive type of lymphoma and neuroblastoma. A phase 1 clinical trial of the drug crizotinib achieved remissions, with minimal side effects, for 10 of the children participating in a clinical study carried out by the multicenter Children's Oncology Group (COG). The results ...]]> http://www.medindia.net/news/clinical-trials-into-new-drug-targeting-abnormal-genes-responsible-for-cancer-provides-encouraging-results-in-phase-i-trial-101572-1.htm http://www.medindia.net/news/new-drug-shows-promise-against-localized-high-risk-prostate-tumors-101554-1.htm A novel hormone-depleting drug helps eliminate tumors in patients with aggressive cancers that have yet to spread beyond the prostate, shows clinical study. The phase II clinical trial, led by investigators at Dana-Farber Cancer Institute and other research centers, examined the use of the drug abiraterone acetate (Zytiga(R)) in combination with prednisone and surgery in 58 men with high-risk prostate cancer isolated to the prostate gland. Participants received either three or six months ...]]> http://www.medindia.net/news/new-drug-shows-promise-against-localized-high-risk-prostate-tumors-101554-1.htm http://www.medindia.net/news/new-drug-candidates-offer-route-to-controlling-inflammation-101536-1.htm New set of molecules have the potential to treat inflammatory diseases such as asthma, rheumatoid arthritis, stroke and sepsis, say researchers. The team started by creating a three-dimensional map of a protein structure called the C3a receptor, which sits on the surface of human cells and plays a critical role in regulating a branch of the immune system called the complement system. They then used computational techniques to design short portions of protein molecules, known as peptides, ...]]> http://www.medindia.net/news/new-drug-candidates-offer-route-to-controlling-inflammation-101536-1.htm http://www.medindia.net/news/new-drug-kills-off-cancer-cells-by-restoring-mutated-tumor-suppressor-protein-101403-1.htm Researchers from The Cancer Institute of New Jersey have identified a new compound that can restore the structure and function of a commonly mutated protein, p53, in human cancer which can then selectively kill off the cancer cells. The research, published by Cell Press in the May 15th issue of the journal iCancer Cell/i, uses a novel, computer based strategy to identify potential anti-cancer drugs, including one that targets the third most common p53 mutation in human cancer, p53-R175H. ...]]> http://www.medindia.net/news/new-drug-kills-off-cancer-cells-by-restoring-mutated-tumor-suppressor-protein-101403-1.htm http://www.medindia.net/news/new-drug-destroys-cancer-cells-by-blocking-its-recycling-mechanism-101331-1.htm Researchers from Perelman School of Medicine, the Abramson Cancer Center and University of Pennsylvania have developed a new drug that blocks the recycling mechanism of cancer cells and destroys the tumors by disabling the ability of repairing themselves from the damage caused by chemotherapy and other cancer treatments. Ravi K. Amaravadi, MD, assistant professor of Medicine, and colleagues showed previously that an old malaria drug, hydroxychloroquine, reduces autophagy in cancer cells and ...]]> http://www.medindia.net/news/new-drug-destroys-cancer-cells-by-blocking-its-recycling-mechanism-101331-1.htm http://www.medindia.net/news/potential-new-drug-targets-via-a-closer-look-at-parp-1-101286-1.htm The molecular details of PARP-1 have been elaborated in a new study published in iScience/i on May 11. The former is a DNA damage-detecting enzyme that when inhibited has been shown to be effective in fighting cancer and other diseases. The investigation led by a href="http:www.jefferson.edu/biochemistry/faculty_profile.cfm?key=jmp007"John M. Pascal, Ph.D./a, an assistant professor in the a href="http:www.jefferson.edu/biochemistry/"Department of Biochemistry and Molecular Biology/a ...]]> http://www.medindia.net/news/potential-new-drug-targets-via-a-closer-look-at-parp-1-101286-1.htm http://www.medindia.net/news/fda-panel-approves-new-drug-for-weight-loss-101162-1.htm The US Food and Drug Administration has been urged by a panel of experts to approve Lorcaserin, a new weight loss drug, developed by Arena Pharmaceuticals. The committee voted 18-4 in favor of the drug, which works to control the appetite through receptors in the brain, after trial data showed it helped nearly half of patients studied lose up to five percent of their body weight. The drug was rejected in 2010 by the Endocrinologic and Metabolic Drugs Advisory Committee, which advises the ...]]> http://www.medindia.net/news/fda-panel-approves-new-drug-for-weight-loss-101162-1.htm http://www.medindia.net/news/clinical-trials-of-pneumonia-vaccine-in-cuba-101051-1.htm The official daily Granma has confirmed that Cuba will begin clinical trials of a new pneumonia vaccine this year. The vaccine was developed by scientists at Havana's Finlay Institute and the Center for Biomolecular Chemistry, Finlay Director Concepcion Campa was quoted as saying by Granma. Campa is participating in the 16th International Seminar of the Caribbean Medical Association, which began Wednesday in Havana and gathered 200 specialists from various countries. Campa gave a lecture ...]]> http://www.medindia.net/news/clinical-trials-of-pneumonia-vaccine-in-cuba-101051-1.htm http://www.medindia.net/news/novel-strategy-in-drug-discovery-100905-1.htm New method developed by Washington University School of Medicine researchers identifies drugs that help fight broad range of virus. "Over many years of research, we have developed a good understanding of the human body''s own mechanisms to fight viruses," says the study''s first author Dhara Patel, PhD, a postdoctoral research scholar at Washington University. "Instead of targeting the virus itself, which most current antiviral drugs do, we have designed a strategy to look for chemical compounds ...]]> http://www.medindia.net/news/novel-strategy-in-drug-discovery-100905-1.htm http://www.medindia.net/news/us-study-finds-clinical-trials-too-small-to-offer-medical-evidence-100796-1.htm A review of the US database of clinical studies released on Tuesday found most clinical trials for cancer, heart disease and mental health too small to offer adequate medical evidence. The analysis in the Journal of the American Medical Association was led by experts at Duke University in collaboration with the US Food and Drug Administration. That partnership, known as the Clinical Trials Transformation Initiative (CTTI), examined more than 96,000 studies registered as of September 2010 with the website ClinicalTrials....]]> http://www.medindia.net/news/us-study-finds-clinical-trials-too-small-to-offer-medical-evidence-100796-1.htm http://www.medindia.net/news/clinical-drug-trials-neglects-children-100758-1.htm Even if kids are likelier to suffer from many diseases than adults, few clinical trials are being conducted to test drugs in paediatric patients, states a study to be presented Saturday, April 28, at the Pediatric Academic Societies (PAS) annual meeting in Boston. Drug studies in children are important because children often respond differently to medications than adults. However, there is widespread concern about the lack of clinical evidence available to guide physicians in prescribing pharmaceuticals to children....]]> http://www.medindia.net/news/clinical-drug-trials-neglects-children-100758-1.htm http://www.medindia.net/news/clinical-trials-to-be-appraised-by-stem-cell-division-100697-1.htm A stem cell division to evaluate proposals relating to stem cell research has been established by The Directorate General of Health Services, said Ghulam Nabi Azad Minister of Health and Family Welfare. Speaking in the Lok Sabha, Azad said the stem cell division was established within the Biological Division in Central Drugs Standard Control Organisation for the internal evaluation of all proposals, including stem cell concerning with clinical trial and marketing authorisation. "Till recently, ...]]> http://www.medindia.net/news/clinical-trials-to-be-appraised-by-stem-cell-division-100697-1.htm http://www.medindia.net/news/azad-stresses-on-the-need-for-more-medical-research-100685-1.htm Union Health Minister Ghulam Nabi Azad has said that more medical research was needed in the country. He also asked doctors to put more service in rural areas. Delivering his address on the occasion of the 32nd convocation of the Post Graduate Institute of Medical Education and Research (PGIMER) here, Azad called upon the medical faculty to intensify their research efforts. The health minister observed that in clinical skills Indian doctors are acclaimed internationally but medical research in the country needs attention....]]> http://www.medindia.net/news/azad-stresses-on-the-need-for-more-medical-research-100685-1.htm http://www.medindia.net/news/new-drug-to-reduce-risk-of-respiratory-viral-infections-100324-1.htm Researchers at University of Southampton are currently developing a new drug that could reduce the risk of respiratory viral infections that lead to worsening of symptoms among asthmatics. Recent figures have revealed that over 80 percent of asthma-related emergency visits are due to respiratory viral infections, such as common cold, which spread to the lungs and cause worsening of asthma attacks. Researchers are currently conducting clinical trials of the drug, known as SNG001, which they hope ...]]> http://www.medindia.net/news/new-drug-to-reduce-risk-of-respiratory-viral-infections-100324-1.htm http://www.medindia.net/news/new-drug-offers-hope-to-patients-with-seizures-100266-1.htm A new anti-epilepsy medication reduces seizure frequency in people with frequent and uncontrollable seizure, reveals Johns Hopkins-led research. "Many other drugs to treat frequent seizures have been released in the last 10 years and for many people, they just don''t work," says study leader Gregory L. Krauss, M.D., a professor of neurology at the Johns Hopkins University School of Medicine. "For a drug-resistant population that has run out of options, this study is good news. These are ...]]> http://www.medindia.net/news/new-drug-offers-hope-to-patients-with-seizures-100266-1.htm http://www.medindia.net/news/clinical-trial-finds-new-prostate-cancer-therapy-effective-with-fewer-side-effects-100232-1.htm Researchers said Tuesday a new prostate cancer treatment using high frequency sound waves may be a suitable alternative to surgery and radiotherapy with less chance of side effects like incontinence or impotence. A clinical trial funded by Britain's Medical Research Council examined the efficacy of a new treatment known as high-intensity focused ultrasound (HIFU), that can target areas just a few millimetres in size. "The results ... show that 12 months after treatment, none of the 41 men ...]]> http://www.medindia.net/news/clinical-trial-finds-new-prostate-cancer-therapy-effective-with-fewer-side-effects-100232-1.htm http://www.medindia.net/news/new-drug-helps-detect-marker-for-alzheimers-disease-earlier-100150-1.htm A novel drug helps doctors detect beta-amyloid plagues in the brain earlier. Beta amyloid plagues are the key signs of Alzheimer's disease, shows research. Currently, Alzheimer's disease can only be definitively confirmed through the detection of amyloid plaques and/or tangles in the brain during autopsy after death or with a brain tissue biopsy. The new method uses the drug florbetaben as a tracer during a PET scan of the brain to visualize amyloid plaques during life. In order to ...]]> http://www.medindia.net/news/new-drug-helps-detect-marker-for-alzheimers-disease-earlier-100150-1.htm http://www.medindia.net/news/lasmiditan-a-new-drug-for-migraine-in-clinical-trials-99765-1.htm bA new oral drug called lasmiditan may be effective in the treatment of migraine, according to a study recently published in the Lancet Neurology journal/b. Migraine is a throbbing and recurring type of headache that is associated with an increase in sensitivity to light, sound and movement, and sometimes nausea and vomiting. It may be preceded by certain visual and other sensory symptoms referred to as aura. Migraine is caused due to abnormal electrical activity in the ...]]> http://www.medindia.net/news/lasmiditan-a-new-drug-for-migraine-in-clinical-trials-99765-1.htm http://www.medindia.net/news/progression-of-osteoarthritis-slowed-by-new-drug-99284-1.htm A new study has indicated that a drug used in osteoporosis has shown promise in slowing down the progression of osteoarthritis. The new findings showed that Protelos (strontium ranelate) reduced deterioration of knee joint cartilage in a group of arthritis patients by a third over three years, significantly reducing pain and improved day-to-day mobility, the Telegraph reported here. Cyrus Cooper, professor from Oxford and Southampton Universities, who led the study, said: "This is a major breakthrough....]]> http://www.medindia.net/news/progression-of-osteoarthritis-slowed-by-new-drug-99284-1.htm http://www.medindia.net/news/keyed-new-drug-marked-to-boost-memory-in-alzheimers-patients-98734-1.htm The protease cathepsin B (CatB) has been verified by researchers as a target to develop memory deficits and shrinking the pathology of Alzheimer's disease (AD), leastways in an animal model. The breakthrough study was conducted jointly by researchers at the University of California, San Diego, the Medical University of South Carolina, the University of Cincinnati and American Life Science Pharmaceuticals of San Diego. According to investigator Vivian Y. H. Hook, PhD, professor of the UCSD ...]]> http://www.medindia.net/news/keyed-new-drug-marked-to-boost-memory-in-alzheimers-patients-98734-1.htm http://www.medindia.net/news/new-drug-target-for-kidney-disease-identified-98705-1.htm Mount Sinai School of Medicine researchers have identified a promising and novel drug target that plays a crucial role in kidney fibrosis. Finding this regulator provides a new therapeutic target for the millions of Americans affected by kidney failure. The research is published in the March 11 issue of iNature Medicine/i. Led by John Cijiang He, MD, PhD, Professor of Nephrology and Pharmacology and Systems Therapeutics; and Avi Ma''ayan, PhD, Assistant Professor of Pharmacology and ...]]> http://www.medindia.net/news/new-drug-target-for-kidney-disease-identified-98705-1.htm http://www.medindia.net/news/new-drug-target-improves-memory-deficits-in-alzheimers-disease-98591-1.htm Researchers at the University of California, San Diego, have found promise in protease cathepsin B (CatB) as a target for improving memory deficits and reducing the pathology of Alzheimer's disease (AD)during experiments conducted on mice. /IAccording to investigator Vivian Y. H. Hook, PhD, professor of the UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences and professor of neurosciences, pharmacology and medicine at the UCSD School of Medicine, the study is important because it could ...]]> http://www.medindia.net/news/new-drug-target-improves-memory-deficits-in-alzheimers-disease-98591-1.htm http://www.medindia.net/news/opioid-induced-constipation-in-critical-care-patients-may-be-reduced-by-new-drug-98306-1.htm Use of opioids in critical care units causes constipation which can lead to adverse outcomes including delayed feeding and later discharge from the ICU. Researchers from London, UK, and Chicago, IL, have found that methylnaltrexone (MNTX), a peripheral opioid antagonist, may restore bowel function in critically ill patients. Their retrospective study appears in the March issue of IMayo Clinic Proceedings/I. "We found MNTX to be very effective in producing laxation when compared with ...]]> http://www.medindia.net/news/opioid-induced-constipation-in-critical-care-patients-may-be-reduced-by-new-drug-98306-1.htm http://www.medindia.net/news/new-drug-extends-survival-rate-in-people-with-myelofibrosis-98197-1.htm Ruxolitinib improves survival and quality of life in patients with a life-threatening bone marrow disorder called myelofibrosis, shows study published in NEJM. "The Phase I/II clinical trial showed that ruxolitinib improves quality of life for many patients with myelofibrosis and now this phase III study indicates that the drug extends survival in a patient population that has lacked effective treatments," said study principal investigator Srdan Verstovsek, M.D., Ph.D., associate professor ...]]> http://www.medindia.net/news/new-drug-extends-survival-rate-in-people-with-myelofibrosis-98197-1.htm http://www.medindia.net/news/new-drug-for-neuro-enocrine-tumors-97915-1.htm A wonder drug to treat neuro-endocrine tumors has been unveiled by The Amrita Centre for Nanosciences. The product has been developed at the Amrita Centre by a team headed by Manzoor Koyakutty. Amrita Centre belongs to Mata Amritananda Mayi. The drug, Nanophotomedicine, was launched at a three-day conference organised by the Amrita Centre for Nanosciences that began here Tuesday. According to Koyakutty, the nanomedicine for neuro-endocrine tumours can eliminate tumour cells ...]]> http://www.medindia.net/news/new-drug-for-neuro-enocrine-tumors-97915-1.htm http://www.medindia.net/news/clinical-trials-for-norovirus-vaccine-on-the-anvil-97671-1.htm Two different groups of researchers in the United States are hoping to conduct clinical trials for their vaccines which they believe will provide protection against the highly infectious norovirus. Also known as the winter vomiting bug, norovirus causes a non fatal stomach illness that lead to violent repeated vomiting and diarrhea. Two groups of researchers, one from the Arizona State University and another at LigoCyte, are hoping to develop liquid nasal sprays to prevent the condition. The researchers ...]]> http://www.medindia.net/news/clinical-trials-for-norovirus-vaccine-on-the-anvil-97671-1.htm http://www.medindia.net/news/azad-says-drug-trials-should-follow-procedures-97165-1.htm Clinical trials should be as per laid down procedures, says Health Minister Ghulam Nabi Azad. "Clinical trials have to be there, but going for a clinical trial for testing any medicine on human being, there is a laid down procedure," Azad said, reacting to the apex court's notice to the central government on a plea seeking investigation into illegal and unethical clinical trials. "...Sometimes the companies don't go by the laid down procedures and it causes great harm to persons and individuals ...]]> http://www.medindia.net/news/azad-says-drug-trials-should-follow-procedures-97165-1.htm http://www.medindia.net/news/new-drug-improves-survival-rate-in-advanced-prostate-cancer-patients-clinical-trial-96954-1.htm Results of a large, phase III clinical trial show a new drug MDV3100, improves the survival rate in men with advanced prostate cancer. The drug is designed to block a type of cellular receptor that drives progression of prostate cancer. Based on the strength of the data from the phase III trial, it is anticipated that the biopharmaceutical company Medivation, which licensed MDV3100, will file a new drug application with the Food and Drug Administration later this year. The presentation of ...]]> http://www.medindia.net/news/new-drug-improves-survival-rate-in-advanced-prostate-cancer-patients-clinical-trial-96954-1.htm http://www.medindia.net/news/new-drug-delivery-system-developed-by-boston-university-researchers-96904-1.htm Long duration, controllable drug delivery is of great importance to medical researchers and clinicians, particularly those seeking to improve treatment for patients with chronic pain or to prevent cancer recurrence after surgery. Now a team of researchers led by Boston University Biomedical Engineer and Chemist Mark Grinstaff has developed a unique material and drug delivery mechanism that could pave the way for implants that release a drug at a designated rate for months. The system consists ...]]> http://www.medindia.net/news/new-drug-delivery-system-developed-by-boston-university-researchers-96904-1.htm http://www.medindia.net/news/clinical-trial-shows-arthritis-and-cholesterol-drugs-are-well-tolerated-in-prostate-cancer-treatment-96881-1.htm FDA-approved drugs Celebrex used for arthritis pain and Lipitor used for lowering cholesterol are well tolerated in the treatment of recurrent prostate cancer, research from The Cancer Institute of New Jersey (CINJ) on the drugs shows. Preliminary results from an ongoing Phase II clinical trial will be presented during the 2012 Genitourinary Cancers Symposium, which is co-sponsored by the American Society of Clinical Oncology (ASCO), the American Society for Radiation Oncology (ASTRO) and the ...]]> http://www.medindia.net/news/clinical-trial-shows-arthritis-and-cholesterol-drugs-are-well-tolerated-in-prostate-cancer-treatment-96881-1.htm http://www.medindia.net/news/new-drug-kalydeco-for-rare-cystic-fibrosis-approved-in-us-96874-1.htm Kalydeco, a new, gene-targeted drug treatment for people who have a rare kind of the incurable lung disease cystic fibrosis was approved by US regulators on Tuesday. Made by the Massachusetts-based Vertex Pharmaceuticals, Kalydeco (ivacaftor) was approved by the US Food and Drug Administration on a fast-track for drugs that may offer big advances over standard therapy. The drug works to restore the balance of salt and water on the surface of the patient's airways, a process that is crucial ...]]> http://www.medindia.net/news/new-drug-kalydeco-for-rare-cystic-fibrosis-approved-in-us-96874-1.htm http://www.medindia.net/news/new-drug-for-common-skin-cancer-96827-1.htm FDA approved erivedge - a new drug to treat basal cell carcinoma, the most common form of skin cancer. Erivedge (vismodegib) is made by Genentech, a US subsidiary of the Swiss drug giant Roche, and was approved by the Food and Drug Administration after an expedited review for drugs that offer the potential for major advances in treatment. The drug is the first of its kind for patients whose basal cell carcinoma has spread either locally or to other parts of the body, or metastasized....]]> http://www.medindia.net/news/new-drug-for-common-skin-cancer-96827-1.htm http://www.medindia.net/news/new-drug-delivery-eliminates-harmful-side-effects-in-transplant-patients-96668-1.htm Scientists are developing a new drug delivery system which would eliminate harmful side effects in organ transplant patients. The drug, cyclosporine (CsA), is widely used in transplant operations and helps prevent the patient's body rejecting the organ but it can cause adverse drug reactions, of which the most serious problems are kidney and liver damage, in the doses which are currently administered in the long term. The gap between a safe, effective dose of the treatment and a toxic dose ...]]> http://www.medindia.net/news/new-drug-delivery-eliminates-harmful-side-effects-in-transplant-patients-96668-1.htm http://www.medindia.net/news/new-guidelines-for-acute-and-preventive-migraine-clinical-trials-96566-1.htm International Headache Society (IHS) experts have developed new migraine clinical trial guidelines. The third edition of Migraine Clinical Trials Guidelines is now available in the IHS journal Cephalalgia, which is published by SAGE.The new guidelines represent an expert consensus summary, and recommend a contemporary, standardized, and evidence-based approach to investigators conducting and reporting randomised, controlled migraine clinical trials. Migraine clinical research has increased ...]]> http://www.medindia.net/news/new-guidelines-for-acute-and-preventive-migraine-clinical-trials-96566-1.htm http://www.medindia.net/news/Demystified-New-Drug-Labels-for-Kidney-Disease-Patients-96409-1.htm Clinicians were asked by the FDA to be more conservative when they prescribe chronic kidney disease (CKD) patients with drugs that treat red blood cell deficiencies. But the drug label's recommendations fall short, according to two commentaries appearing in an upcoming issue of the IClinical Journal of the American Society Nephrology/I (CJASN). The A HREF="http:www.fda.gov/Drugs/DrugSafety/ucm259639.htm"new federal recommendations/A apply to erythropoiesis-stimulating agents (ESAs)....]]> http://www.medindia.net/news/Demystified-New-Drug-Labels-for-Kidney-Disease-Patients-96409-1.htm http://www.medindia.net/news/Clinical-Trial-Using-Stem-Cell-in-Parkinsons-Disease-Likely-in-Near-Future-96309-1.htm bParkinson's Disease/b - Medical world has struggled in finding permanent cure for this condition that usually affects men over the age of 50 years, but now this maybe changing with the advent of stem cell based research in regenerative medicine. A significant clinical human trial using these technique now seems feasible in the near future. bParkinson's disease is a neurodegenenerative disorder of the brain that leads to shaking (tremors) and difficulty with walking, movement, and coordination....]]> http://www.medindia.net/news/Clinical-Trial-Using-Stem-Cell-in-Parkinsons-Disease-Likely-in-Near-Future-96309-1.htm http://www.medindia.net/news/Caltech-Chemists-Formulate-Chemical-Reaction-Anticipating-New-Drug-Development-96201-1.htm New method to make complex molecules has been devised by researchers at the California Institute of Technology (Caltech).The reaction they have come up with should enable chemists to synthesize new varieties of a whole subclass of organic compounds called nitrogen-containing heterocycles, thus opening up new avenues for the development of novel pharmaceuticals and natural products ranging from chemotherapeutic compounds to bioactive plant materials such as morphine. The team-led by Brian Stoltz, ...]]> http://www.medindia.net/news/Caltech-Chemists-Formulate-Chemical-Reaction-Anticipating-New-Drug-Development-96201-1.htm http://www.medindia.net/news/Clinical-Trial-Result-Rilonacept-Significantly-Reduces-Gout-Flares-95738-1.htm Rilonacept, an inhibitor of the protein interleukin-1 (IL-1), significantly reduced acute gout flares that occur when initiating uric acid-lowering therapy, a phase II clinical trial found. Results of the trial-the first placebo-controlled study investigating IL-1 targeted therapy in prevention of gout flares-show rilonacept to be generally well tolerated with no serious infections or treatment-related serious adverse events reported. Full findings are published in iArthritis (and) Rheumatism/i, ...]]> http://www.medindia.net/news/Clinical-Trial-Result-Rilonacept-Significantly-Reduces-Gout-Flares-95738-1.htm http://www.medindia.net/news/Once-promising-Genital-Herpes-Vaccine-Fails-in-a-Large-Clinical-Trial-95722-1.htm A once-promising genital herpes vaccine has failed in a large clinical trial, reported researchers. Researchers found that the vaccine efficacy was only 20%.About 8,300 uninfected women, aged 18-30 years, were part of this new study. Researchers found that the experimental genital herpes shot was only mildly effective against herpes simplex virus type 1 (HSV-1), which commonly causes cold sores and sometimes genital herpes; and not at all effective against herpes simplex virus 2 (HSV-2), the most common cause of genital herpes....]]> http://www.medindia.net/news/Once-promising-Genital-Herpes-Vaccine-Fails-in-a-Large-Clinical-Trial-95722-1.htm http://www.medindia.net/news/Several-NIH-Funded-Clinical-Trials-Go-Unpublished-Limited-Years-After-Completion-95693-1.htm Study investigated the challenges of disseminating clinical research findings in peer-reviewed biomedical journals at Yale School of Medicine. The researchers found lesser than half of a sample of trials primarily or partially funded by the National Institutes of Health (NIH) were published within 30 months of completing the clinical trial. These findings appear in the January issue of the IBritish Medical Journal/I, which focuses on the topic of unpublished evidence. "When research ...]]> http://www.medindia.net/news/Several-NIH-Funded-Clinical-Trials-Go-Unpublished-Limited-Years-After-Completion-95693-1.htm http://www.medindia.net/news/Secret-Drug-Trials-On-Indian-Children-Provoke-Activists-Anger-95656-1.htm A petty fine of just 5,000 rupees ( (Dollor) 94) each on 12 doctors for conducting secret drug trials on children and patients with learning disabilities has triggered an outcry among Indian activists. The Madhya Pradesh state government said the tests had not been cleared by health authorities, and it added that the doctors refused to disclose further details citing patient confidentiality laws. Anand Rai, a doctor who acted as a whistle-blower over the case, told AFP on Tuesday he was angered and ...]]> http://www.medindia.net/news/Secret-Drug-Trials-On-Indian-Children-Provoke-Activists-Anger-95656-1.htm http://www.medindia.net/news/Indian-Authorities-Criticized-Over-Low-Fine-for-Drug-Trials-95647-1.htm Indian authorities have been criticized for letting off lightly 12 doctors in the state of Madhya Pradesh who conducted drug trials on children and patients with learning disabilities.The doctors failed to maintain records of tests and inform the details to the Chief Medical and Health Officer under the Madhya Pradesh Nursing Homes and Clinical Establishments (Registration and License) Act. The doctors were just fined Rupees 5,000 ( (Dollor) 94) each. The trials of the drug to treat sexual dysfunction were conducted in the city of Indore....]]> http://www.medindia.net/news/Indian-Authorities-Criticized-Over-Low-Fine-for-Drug-Trials-95647-1.htm http://www.medindia.net/news/Blood-Pressure-Medicine-Gives-Longer-Life-Clinical-Trial-Reveals-95092-1.htm People who took blood pressure medicine during a 1980s clinical trial were found to live longer two decades later, than people who took a placebo, a US study said on Tuesday. The randomized trial included 4,736 patients aged 60 and over who had high blood pressure. Some were given a drug called chlorthalidone and others were given a sugar pill for a 4.5 year period beginning in 1985. At the end of the Systolic Hypertension in the Elderly Program (SHEP) trial, all participants were advised to begin following the drug regimen....]]> http://www.medindia.net/news/Blood-Pressure-Medicine-Gives-Longer-Life-Clinical-Trial-Reveals-95092-1.htm http://www.medindia.net/news/New-Drug-Therapy-Target-to-Treat-Stress-Disorders-Identified-94742-1.htm For the first time neuroscience researchers from Tufts have demonstrated, that the physiological response to stress depends on neurosteroids acting on specific receptors in the brain, and they have been able to block that response in mice. This breakthrough suggests that these critical receptors may be drug therapy targets for control of the stress-response pathway. This finding may pave the way for new approaches to manage a wide range of neurological disorders involving stress. The stress-control ...]]> http://www.medindia.net/news/New-Drug-Therapy-Target-to-Treat-Stress-Disorders-Identified-94742-1.htm http://www.medindia.net/news/New-Drug-Treatments-to-Prevent-Atherosclerosis-94557-1.htm Hardening of arteries or atherosclerosis treatment can be improved by new discovery, says study. The researchers showed that by changing the behaviour of endothelial cells in hardened vessels, without making the vessels any less stiff, they could reduce the effects of aging on vessel health. This was achieved by dulling the vessels' inflammatory response to stiffening by, in essence, tricking the cells in the blood vessels into thinking the vessels were not stiff. "One of the things ...]]> http://www.medindia.net/news/New-Drug-Treatments-to-Prevent-Atherosclerosis-94557-1.htm http://www.medindia.net/news/Research-Sheds-Light-on-How-to-Better-Predict-Success-in-HIV-Prevention-Clinical-Trials-94529-1.htm The failure of some recent clinical trials of prevention of HIV infection, compared to the success of others that used the same drugs might be explained by new research from the University of North Carolina at Chapel Hill schools of medicine and pharmacy. The study published online December 7, 2011 in the journal IScience Translational Medicine/I, also suggests how to improve the chances for success, even before the research begins. These suggestions are reinforced in an editorial by several ...]]> http://www.medindia.net/news/Research-Sheds-Light-on-How-to-Better-Predict-Success-in-HIV-Prevention-Clinical-Trials-94529-1.htm http://www.medindia.net/news/New-Drug-Combination-Delays-Breast-Cancer-Progression-94464-1.htm Researchers found that a combination of drugs increased breast cancer survival in postmenopausal women. The results of the phase III trial, released at a meeting of breast cancer experts in San Antonio, Texas, show the first benefit for women with hormone receptor-positive metastatic breast cancer in 10 years, study authors said. Both drugs -- anastrozole (Arimidex) and fulvestrant (Faslodex) -- are currently used to treat breast cancer but they have typically been administered separately, not together....]]> http://www.medindia.net/news/New-Drug-Combination-Delays-Breast-Cancer-Progression-94464-1.htm http://www.medindia.net/news/Whole-Genome-Sequencing-Clinical-Trials-for-Triple-Negative-Breast-Cancer-94297-1.htm Previous research has shown that triple negative breast tumors make up nearly 20 percent of breast cancers. These cancers do not respond to treatment with targeted therapies such as Herceptin (Regd) (trastuzumab). To investigate new options for these patients, the first clinical trial of whole-genome sequencing for women with triple negative breast cancer was initiated in March 2010, and the first results will be presented during the 2011 CTRC-AACR San Antonio Breast Cancer Symposium, Dec. 6-10, 2011....]]> http://www.medindia.net/news/Whole-Genome-Sequencing-Clinical-Trials-for-Triple-Negative-Breast-Cancer-94297-1.htm