http://www.medindia.net/healthnews/Clinical-Trials-news.asp Medindia largest health website in india. en-us Copyright 2012. All Rights Reserved. Fri, 25 May 2012 05:04:53 GMT http://www.medindia.net/news/heat-shock-protein-inhibitor-and-hormonal-therapy-combo-tested-in-breast-cancer-clinical-trial-101624-1.htm Pushed to the edge of survival, the hyper-driven cells of a cancerous tumor tap into an ancient system that has helped organisms cope with internal stresses and environmental challenges since life began. Most importantly in this system, heat shock protein 90 (HSP90) has been shown to help malignant cells accommodate the genetic changes and profound disturbances in normal biology that occur in cancers. Researchers have theorized that inhibiting HSP90 just might render breast cancer cells less ...]]> http://www.medindia.net/news/heat-shock-protein-inhibitor-and-hormonal-therapy-combo-tested-in-breast-cancer-clinical-trial-101624-1.htm http://www.medindia.net/news/verify-clinical-trials-of-non-skeletal-benefits-of-vitamin-d-demand-experts-101600-1.htm New scientific statement on representation of the first comprehensive evaluation of both the basic and clinical evidence linked to the non-skeletal effects of vitamin D published online by The Endocrine Society. The statement addresses current research regarding the associations of vitamin D with immune function, hypertension, stroke, skin conditions and maternal/fetal health. Vitamin D is a steroid hormone that regulates calcium and phosphate levels in the bloodstream and promotes healthy bone growth....]]> http://www.medindia.net/news/verify-clinical-trials-of-non-skeletal-benefits-of-vitamin-d-demand-experts-101600-1.htm http://www.medindia.net/news/clinical-trials-into-new-drug-targeting-abnormal-genes-responsible-for-cancer-provides-encouraging-results-in-phase-i-trial-101572-1.htm Clinical trials testing out a new drug, which targets abnormal genes that are responsible for specific cancers, have given encouraging signs to researchers who are testing the drugs in children suffering from a rare and aggressive type of lymphoma and neuroblastoma. A phase 1 clinical trial of the drug crizotinib achieved remissions, with minimal side effects, for 10 of the children participating in a clinical study carried out by the multicenter Children's Oncology Group (COG). The results ...]]> http://www.medindia.net/news/clinical-trials-into-new-drug-targeting-abnormal-genes-responsible-for-cancer-provides-encouraging-results-in-phase-i-trial-101572-1.htm http://www.medindia.net/news/clinical-trials-of-pneumonia-vaccine-in-cuba-101051-1.htm The official daily Granma has confirmed that Cuba will begin clinical trials of a new pneumonia vaccine this year. The vaccine was developed by scientists at Havana's Finlay Institute and the Center for Biomolecular Chemistry, Finlay Director Concepcion Campa was quoted as saying by Granma. Campa is participating in the 16th International Seminar of the Caribbean Medical Association, which began Wednesday in Havana and gathered 200 specialists from various countries. Campa gave a lecture ...]]> http://www.medindia.net/news/clinical-trials-of-pneumonia-vaccine-in-cuba-101051-1.htm http://www.medindia.net/news/novel-strategy-in-drug-discovery-100905-1.htm New method developed by Washington University School of Medicine researchers identifies drugs that help fight broad range of virus. "Over many years of research, we have developed a good understanding of the human body''s own mechanisms to fight viruses," says the study''s first author Dhara Patel, PhD, a postdoctoral research scholar at Washington University. "Instead of targeting the virus itself, which most current antiviral drugs do, we have designed a strategy to look for chemical compounds ...]]> http://www.medindia.net/news/novel-strategy-in-drug-discovery-100905-1.htm http://www.medindia.net/news/us-study-finds-clinical-trials-too-small-to-offer-medical-evidence-100796-1.htm A review of the US database of clinical studies released on Tuesday found most clinical trials for cancer, heart disease and mental health too small to offer adequate medical evidence. The analysis in the Journal of the American Medical Association was led by experts at Duke University in collaboration with the US Food and Drug Administration. That partnership, known as the Clinical Trials Transformation Initiative (CTTI), examined more than 96,000 studies registered as of September 2010 with the website ClinicalTrials....]]> http://www.medindia.net/news/us-study-finds-clinical-trials-too-small-to-offer-medical-evidence-100796-1.htm http://www.medindia.net/news/clinical-drug-trials-neglects-children-100758-1.htm Even if kids are likelier to suffer from many diseases than adults, few clinical trials are being conducted to test drugs in paediatric patients, states a study to be presented Saturday, April 28, at the Pediatric Academic Societies (PAS) annual meeting in Boston. Drug studies in children are important because children often respond differently to medications than adults. However, there is widespread concern about the lack of clinical evidence available to guide physicians in prescribing pharmaceuticals to children....]]> http://www.medindia.net/news/clinical-drug-trials-neglects-children-100758-1.htm http://www.medindia.net/news/clinical-trials-to-be-appraised-by-stem-cell-division-100697-1.htm A stem cell division to evaluate proposals relating to stem cell research has been established by The Directorate General of Health Services, said Ghulam Nabi Azad Minister of Health and Family Welfare. Speaking in the Lok Sabha, Azad said the stem cell division was established within the Biological Division in Central Drugs Standard Control Organisation for the internal evaluation of all proposals, including stem cell concerning with clinical trial and marketing authorisation. "Till recently, ...]]> http://www.medindia.net/news/clinical-trials-to-be-appraised-by-stem-cell-division-100697-1.htm http://www.medindia.net/news/azad-stresses-on-the-need-for-more-medical-research-100685-1.htm Union Health Minister Ghulam Nabi Azad has said that more medical research was needed in the country. He also asked doctors to put more service in rural areas. Delivering his address on the occasion of the 32nd convocation of the Post Graduate Institute of Medical Education and Research (PGIMER) here, Azad called upon the medical faculty to intensify their research efforts. The health minister observed that in clinical skills Indian doctors are acclaimed internationally but medical research in the country needs attention....]]> http://www.medindia.net/news/azad-stresses-on-the-need-for-more-medical-research-100685-1.htm http://www.medindia.net/news/clinical-trial-finds-new-prostate-cancer-therapy-effective-with-fewer-side-effects-100232-1.htm Researchers said Tuesday a new prostate cancer treatment using high frequency sound waves may be a suitable alternative to surgery and radiotherapy with less chance of side effects like incontinence or impotence. A clinical trial funded by Britain's Medical Research Council examined the efficacy of a new treatment known as high-intensity focused ultrasound (HIFU), that can target areas just a few millimetres in size. "The results ... show that 12 months after treatment, none of the 41 men ...]]> http://www.medindia.net/news/clinical-trial-finds-new-prostate-cancer-therapy-effective-with-fewer-side-effects-100232-1.htm http://www.medindia.net/news/lasmiditan-a-new-drug-for-migraine-in-clinical-trials-99765-1.htm bA new oral drug called lasmiditan may be effective in the treatment of migraine, according to a study recently published in the Lancet Neurology journal/b. Migraine is a throbbing and recurring type of headache that is associated with an increase in sensitivity to light, sound and movement, and sometimes nausea and vomiting. It may be preceded by certain visual and other sensory symptoms referred to as aura. Migraine is caused due to abnormal electrical activity in the ...]]> http://www.medindia.net/news/lasmiditan-a-new-drug-for-migraine-in-clinical-trials-99765-1.htm http://www.medindia.net/news/clinical-trials-for-norovirus-vaccine-on-the-anvil-97671-1.htm Two different groups of researchers in the United States are hoping to conduct clinical trials for their vaccines which they believe will provide protection against the highly infectious norovirus. Also known as the winter vomiting bug, norovirus causes a non fatal stomach illness that lead to violent repeated vomiting and diarrhea. Two groups of researchers, one from the Arizona State University and another at LigoCyte, are hoping to develop liquid nasal sprays to prevent the condition. The researchers ...]]> http://www.medindia.net/news/clinical-trials-for-norovirus-vaccine-on-the-anvil-97671-1.htm http://www.medindia.net/news/azad-says-drug-trials-should-follow-procedures-97165-1.htm Clinical trials should be as per laid down procedures, says Health Minister Ghulam Nabi Azad. "Clinical trials have to be there, but going for a clinical trial for testing any medicine on human being, there is a laid down procedure," Azad said, reacting to the apex court's notice to the central government on a plea seeking investigation into illegal and unethical clinical trials. "...Sometimes the companies don't go by the laid down procedures and it causes great harm to persons and individuals ...]]> http://www.medindia.net/news/azad-says-drug-trials-should-follow-procedures-97165-1.htm http://www.medindia.net/news/new-drug-improves-survival-rate-in-advanced-prostate-cancer-patients-clinical-trial-96954-1.htm Results of a large, phase III clinical trial show a new drug MDV3100, improves the survival rate in men with advanced prostate cancer. The drug is designed to block a type of cellular receptor that drives progression of prostate cancer. Based on the strength of the data from the phase III trial, it is anticipated that the biopharmaceutical company Medivation, which licensed MDV3100, will file a new drug application with the Food and Drug Administration later this year. The presentation of ...]]> http://www.medindia.net/news/new-drug-improves-survival-rate-in-advanced-prostate-cancer-patients-clinical-trial-96954-1.htm http://www.medindia.net/news/clinical-trial-shows-arthritis-and-cholesterol-drugs-are-well-tolerated-in-prostate-cancer-treatment-96881-1.htm FDA-approved drugs Celebrex used for arthritis pain and Lipitor used for lowering cholesterol are well tolerated in the treatment of recurrent prostate cancer, research from The Cancer Institute of New Jersey (CINJ) on the drugs shows. Preliminary results from an ongoing Phase II clinical trial will be presented during the 2012 Genitourinary Cancers Symposium, which is co-sponsored by the American Society of Clinical Oncology (ASCO), the American Society for Radiation Oncology (ASTRO) and the ...]]> http://www.medindia.net/news/clinical-trial-shows-arthritis-and-cholesterol-drugs-are-well-tolerated-in-prostate-cancer-treatment-96881-1.htm http://www.medindia.net/news/new-guidelines-for-acute-and-preventive-migraine-clinical-trials-96566-1.htm International Headache Society (IHS) experts have developed new migraine clinical trial guidelines. The third edition of Migraine Clinical Trials Guidelines is now available in the IHS journal Cephalalgia, which is published by SAGE.The new guidelines represent an expert consensus summary, and recommend a contemporary, standardized, and evidence-based approach to investigators conducting and reporting randomised, controlled migraine clinical trials. Migraine clinical research has increased ...]]> http://www.medindia.net/news/new-guidelines-for-acute-and-preventive-migraine-clinical-trials-96566-1.htm http://www.medindia.net/news/Clinical-Trial-Using-Stem-Cell-in-Parkinsons-Disease-Likely-in-Near-Future-96309-1.htm bParkinson's Disease/b - Medical world has struggled in finding permanent cure for this condition that usually affects men over the age of 50 years, but now this maybe changing with the advent of stem cell based research in regenerative medicine. A significant clinical human trial using these technique now seems feasible in the near future. bParkinson's disease is a neurodegenenerative disorder of the brain that leads to shaking (tremors) and difficulty with walking, movement, and coordination....]]> http://www.medindia.net/news/Clinical-Trial-Using-Stem-Cell-in-Parkinsons-Disease-Likely-in-Near-Future-96309-1.htm http://www.medindia.net/news/Clinical-Trial-Result-Rilonacept-Significantly-Reduces-Gout-Flares-95738-1.htm Rilonacept, an inhibitor of the protein interleukin-1 (IL-1), significantly reduced acute gout flares that occur when initiating uric acid-lowering therapy, a phase II clinical trial found. Results of the trial-the first placebo-controlled study investigating IL-1 targeted therapy in prevention of gout flares-show rilonacept to be generally well tolerated with no serious infections or treatment-related serious adverse events reported. Full findings are published in iArthritis (and) Rheumatism/i, ...]]> http://www.medindia.net/news/Clinical-Trial-Result-Rilonacept-Significantly-Reduces-Gout-Flares-95738-1.htm http://www.medindia.net/news/Once-promising-Genital-Herpes-Vaccine-Fails-in-a-Large-Clinical-Trial-95722-1.htm A once-promising genital herpes vaccine has failed in a large clinical trial, reported researchers. Researchers found that the vaccine efficacy was only 20%.About 8,300 uninfected women, aged 18-30 years, were part of this new study. Researchers found that the experimental genital herpes shot was only mildly effective against herpes simplex virus type 1 (HSV-1), which commonly causes cold sores and sometimes genital herpes; and not at all effective against herpes simplex virus 2 (HSV-2), the most common cause of genital herpes....]]> http://www.medindia.net/news/Once-promising-Genital-Herpes-Vaccine-Fails-in-a-Large-Clinical-Trial-95722-1.htm http://www.medindia.net/news/Several-NIH-Funded-Clinical-Trials-Go-Unpublished-Limited-Years-After-Completion-95693-1.htm Study investigated the challenges of disseminating clinical research findings in peer-reviewed biomedical journals at Yale School of Medicine. The researchers found lesser than half of a sample of trials primarily or partially funded by the National Institutes of Health (NIH) were published within 30 months of completing the clinical trial. These findings appear in the January issue of the IBritish Medical Journal/I, which focuses on the topic of unpublished evidence. "When research ...]]> http://www.medindia.net/news/Several-NIH-Funded-Clinical-Trials-Go-Unpublished-Limited-Years-After-Completion-95693-1.htm http://www.medindia.net/news/Secret-Drug-Trials-On-Indian-Children-Provoke-Activists-Anger-95656-1.htm A petty fine of just 5,000 rupees ( (Dollor) 94) each on 12 doctors for conducting secret drug trials on children and patients with learning disabilities has triggered an outcry among Indian activists. The Madhya Pradesh state government said the tests had not been cleared by health authorities, and it added that the doctors refused to disclose further details citing patient confidentiality laws. Anand Rai, a doctor who acted as a whistle-blower over the case, told AFP on Tuesday he was angered and ...]]> http://www.medindia.net/news/Secret-Drug-Trials-On-Indian-Children-Provoke-Activists-Anger-95656-1.htm http://www.medindia.net/news/Indian-Authorities-Criticized-Over-Low-Fine-for-Drug-Trials-95647-1.htm Indian authorities have been criticized for letting off lightly 12 doctors in the state of Madhya Pradesh who conducted drug trials on children and patients with learning disabilities.The doctors failed to maintain records of tests and inform the details to the Chief Medical and Health Officer under the Madhya Pradesh Nursing Homes and Clinical Establishments (Registration and License) Act. The doctors were just fined Rupees 5,000 ( (Dollor) 94) each. The trials of the drug to treat sexual dysfunction were conducted in the city of Indore....]]> http://www.medindia.net/news/Indian-Authorities-Criticized-Over-Low-Fine-for-Drug-Trials-95647-1.htm http://www.medindia.net/news/Blood-Pressure-Medicine-Gives-Longer-Life-Clinical-Trial-Reveals-95092-1.htm People who took blood pressure medicine during a 1980s clinical trial were found to live longer two decades later, than people who took a placebo, a US study said on Tuesday. The randomized trial included 4,736 patients aged 60 and over who had high blood pressure. Some were given a drug called chlorthalidone and others were given a sugar pill for a 4.5 year period beginning in 1985. At the end of the Systolic Hypertension in the Elderly Program (SHEP) trial, all participants were advised to begin following the drug regimen....]]> http://www.medindia.net/news/Blood-Pressure-Medicine-Gives-Longer-Life-Clinical-Trial-Reveals-95092-1.htm http://www.medindia.net/news/Research-Sheds-Light-on-How-to-Better-Predict-Success-in-HIV-Prevention-Clinical-Trials-94529-1.htm The failure of some recent clinical trials of prevention of HIV infection, compared to the success of others that used the same drugs might be explained by new research from the University of North Carolina at Chapel Hill schools of medicine and pharmacy. The study published online December 7, 2011 in the journal IScience Translational Medicine/I, also suggests how to improve the chances for success, even before the research begins. These suggestions are reinforced in an editorial by several ...]]> http://www.medindia.net/news/Research-Sheds-Light-on-How-to-Better-Predict-Success-in-HIV-Prevention-Clinical-Trials-94529-1.htm http://www.medindia.net/news/Whole-Genome-Sequencing-Clinical-Trials-for-Triple-Negative-Breast-Cancer-94297-1.htm Previous research has shown that triple negative breast tumors make up nearly 20 percent of breast cancers. These cancers do not respond to treatment with targeted therapies such as Herceptin (Regd) (trastuzumab). To investigate new options for these patients, the first clinical trial of whole-genome sequencing for women with triple negative breast cancer was initiated in March 2010, and the first results will be presented during the 2011 CTRC-AACR San Antonio Breast Cancer Symposium, Dec. 6-10, 2011....]]> http://www.medindia.net/news/Whole-Genome-Sequencing-Clinical-Trials-for-Triple-Negative-Breast-Cancer-94297-1.htm http://www.medindia.net/news/Safety-of-Customized-Gene-Therapy-Highlighted-in-Clinical-Trial-for-Muscular-Dystrophy-94230-1.htm It is safe to cut and paste together different viruses in an effort to create the ultimate vehicle for gene therapy, researchers at the University of North Carolina at Chapel Hill. In a phase I clinical trial, the investigators found no side effects from using a "chimeric" virus to deliver replacement genes for an essential muscle protein in patients with muscular dystrophy. "This trial demonstrates that gene therapy is no longer limited by the viruses we find in nature, and should usher ...]]> http://www.medindia.net/news/Safety-of-Customized-Gene-Therapy-Highlighted-in-Clinical-Trial-for-Muscular-Dystrophy-94230-1.htm http://www.medindia.net/news/Clinical-Trial-Results-Announced-for-Sunshine-Hearts-C-Pulse-Cardiac-Pump-93728-1.htm Global medical device company Sunshine Heart has announced results of the FDA-approved feasibility clinical trial for its C-Pulse System. This system was implanted in 20 patients at 8 approved sites in North America. Eighteen patients in the trial had Class III heart failure, while 2 had Class IV heart failure. Results indicated that there were significant improvements in NYHA Class reduction, Quality of Life and Left Ventricular Ejection Fraction in the patients. "The completion of the C-Pulse ...]]> http://www.medindia.net/news/Clinical-Trial-Results-Announced-for-Sunshine-Hearts-C-Pulse-Cardiac-Pump-93728-1.htm http://www.medindia.net/news/India-Says-Loopholes-Leading-to-Guinea-Pig-Medical-Trials-Will-be-Fixed-93614-1.htm After it emerged that many poor and illiterate people in India are becoming 'guinea pigs' for drugs trials conducted by various companies, Indian authorities have vowed to tighten regulations over the way medical trials are conducted in the country. An investigation by The Independent recently revealed that pharmaceutical firms in the West have seized on developing countries like India over the past five years as a testing ground for drugs, where research costs for lucrative products to be sold in the Western nations are very low....]]> http://www.medindia.net/news/India-Says-Loopholes-Leading-to-Guinea-Pig-Medical-Trials-Will-be-Fixed-93614-1.htm http://www.medindia.net/news/Drug-Discovery-Process-into-a-New-Class-of-Drugs-Opened-Up-by-Scripps-Research-Team-93090-1.htm One of the most important cancer drugs ever discovered by researchers is Taxol (Regd) . The latter belongs to a class of drugs called taxanes. But the difficulty producing these complex molecules in the lab has hampered or blocked exploration of the family for further drug leads. Now, a group of Scripps Research Institute scientists has successfully achieved a major step toward the goal of synthetically producing Taxol (Regd) and other complex taxanes on a quest to harness chemical reactions that could enable ...]]> http://www.medindia.net/news/Drug-Discovery-Process-into-a-New-Class-of-Drugs-Opened-Up-by-Scripps-Research-Team-93090-1.htm http://www.medindia.net/news/Drug-Trial-for-Lung-Disease-Shows-Promising-Results-92910-1.htm Researchers in the US have revealed that a new gene-targeted treatment for cystic fibrosis has shown promise toward treating a small number of those affected by the incurable disease. Published in the New England Journal of Medicine, the results of the phase III trial using the drug ivacaftor showed it could improve lung function by acting against the defect which causes the disease. Made by the US-based Vertex Pharmaceuticals, the drug works to restore the balance of salt and water on the surface of the patient's airways....]]> http://www.medindia.net/news/Drug-Trial-for-Lung-Disease-Shows-Promising-Results-92910-1.htm http://www.medindia.net/news/Clinical-Trial-Shows-New-Medication-Effectively-Improves-Lung-Function-in-Cystic-Fibrosis-Patients-92856-1.htm A new study has confirmed that the drug, ivacaftor (VX-770), greatly improves lung function in some people with cystic fibrosis (CF). The results of the phase III clinical trial study, "A CFTR Potentiator in Patients with Cystic Fibrosis and the G551D Mutation," led by Bonnie W. Ramsey, MD of Seattle Children's Research Institute and the University of Washington, were published in the iNew England Journal of Medicine/i. Ivacaftor, also known as VX-770, was developed by Vertex Pharmaceuticals ...]]> http://www.medindia.net/news/Clinical-Trial-Shows-New-Medication-Effectively-Improves-Lung-Function-in-Cystic-Fibrosis-Patients-92856-1.htm http://www.medindia.net/news/First-Clinical-Trial-of-Red-Wine-Ingredient-Shows-Improved-Metabolic-Health-92824-1.htm When obese men take a relatively small dose of resveratrol, a natural compound and a key ingredient in red wine, in purified form every day for a month, their metabolisms change for the better. In fact, the effects appear to be as good for us as severe calorie restriction. "We saw a lot of small effects, but consistently pointing in a good direction of improved metabolic health," said Patrick Schrauwen of Maastricht University in The Netherlands. The findings in the November issue of the ...]]> http://www.medindia.net/news/First-Clinical-Trial-of-Red-Wine-Ingredient-Shows-Improved-Metabolic-Health-92824-1.htm http://www.medindia.net/news/Circadian-Technologies-Investigative-Cancer-Drug-Receives-FDA-Nod-for-Clinical-Trials-92786-1.htm Australian biotechnology company, Circadian Technologies announced that its subsidiary company, Vegenics' New Drug Application for its investigative cancer drug has been approved by the US Food and Drug Administration and the company will be conducting clinical trials for the drug. The company's chief executive Robert Klupacs said that they are finalizing clinical trial sites in the United States and will initiate the clinical trials for the drug, known as VGX-100, by the end of this year with ...]]> http://www.medindia.net/news/Circadian-Technologies-Investigative-Cancer-Drug-Receives-FDA-Nod-for-Clinical-Trials-92786-1.htm http://www.medindia.net/news/Drugs-Trials-Result-Challenged-Possible-Side-Effect-in-Macular-Degeneration-Drug-92501-1.htm Though two major drug trials conclude there was little risk from a drug aimed at age-related macular degeneration, a Mayo Clinic ophthalmologist began to note something concerning in some of her patients: an increase in pressure inside the eye. This led to a retrospective study and findings that will be presented at the American Academy of Ophthalmology in Orlando. Sophie Bakri, M.D., had been treating patients in her clinic with Food and Drug Administration-approved ranibizumab (Lucentis), when she began noticing a change in some patients....]]> http://www.medindia.net/news/Drugs-Trials-Result-Challenged-Possible-Side-Effect-in-Macular-Degeneration-Drug-92501-1.htm http://www.medindia.net/news/Clinical-Trial-Results-on-Early-HIV-Treatment-in-HIV-Patients-With-TB-92235-1.htm Starting HIV therapy in HIV patients co-infected with TB within two weeks of TB treatment, rather than two months as is the current practice, increases survival by 33 percent, according to a large-scale clinical trial in Cambodia led by researchers at Children's Hospital Boston and the Immune Disease Institute (IDI). The study's results - reported by Anne Goldfeld, MD, of the IDI and the Program in Cellular and Molecular Medicine at Children's Hospital Boston, and the CAMELIA (Cambodian Early ...]]> http://www.medindia.net/news/Clinical-Trial-Results-on-Early-HIV-Treatment-in-HIV-Patients-With-TB-92235-1.htm http://www.medindia.net/news/Medical-Research-and-the-Elimination-of-Bias-92199-1.htm Researchers have always found it tricky to exactly evaluate a patient's claims. For example, most people are rather vague when reporting on food and drink consumption, smoking and exercise habits. General practitioners, however, are skilled at interpreting phrases such as "I only have a few drinks rarely...each week" and "I get to the gym regularly" and can estimate based on symptoms and a person's physical appearance just how precise those claims are. However, it is crucial for healthcare research ...]]> http://www.medindia.net/news/Medical-Research-and-the-Elimination-of-Bias-92199-1.htm http://www.medindia.net/news/Roches-Alzheimers-Drug-Shows-Promise-in-Clinical-Trial-91802-1.htm A new drug being developed by Roche to treat Alzheimer's has found some success in a small clinical trial after a new report published in the Archive of Neurology revealed that it was able to remove amyloid plaques from the brains of Alzheimer's disease patients. The study was led by Dr Susanne Ostrowitzki in Switzerland and included 16 patients suffering from Alzheimer's. The researchers divided the patients into two groups, and each group was given two to seven infusions of intravenous gantenerumab ...]]> http://www.medindia.net/news/Roches-Alzheimers-Drug-Shows-Promise-in-Clinical-Trial-91802-1.htm http://www.medindia.net/news/More-Cancer-Patients-in-Clinical-Trials-Possible-With-New-Multimedia-Tool-91550-1.htm A new study suggests more cancer patients could enroll for clinical trials with a new multimedia informed consent tool accessed via the Internet that is simple and easier to understand and could make them feel comfortable to enroll in clinical trials. The study conducted by researchers in the Perelman School of Medicine at the University of Pennsylvania will be presented at the American Society for Radiation Oncology's (ASTRO) 53rd Annual Meeting. The research group points to the tool as a potential ...]]> http://www.medindia.net/news/More-Cancer-Patients-in-Clinical-Trials-Possible-With-New-Multimedia-Tool-91550-1.htm http://www.medindia.net/news/Even-When-They-Will-Not-Lead-to-Any-Drug-Companies-Must-Report-Clinical-Trial-Results-91363-1.htm A commentary co-authored by a leading UC Davis drug researcher says that drug companies sponsoring human trials of possible new medications have ethical responsibilities to study participants and to science to disclose the results of their clinical research even when product development is no longer being pursued. The commentary is published online today in IScience Translational Medicine. /IIn the commentary, titled "Disclosure of Clinical Trial Results When Product Development is Abandoned," ...]]> http://www.medindia.net/news/Even-When-They-Will-Not-Lead-to-Any-Drug-Companies-Must-Report-Clinical-Trial-Results-91363-1.htm http://www.medindia.net/news/Promising-Show-By-HIV-Vaccine-MVA-B-In-Clinical-Trials-91233-1.htm The Spanish vaccine MVA-B has been found quite effective against HIV in Phase I clinical trials. As many as 90% of the volunteers who went through the tests developed an immunological response against the virus and 85% kept this response for at least one year. The vaccine has been developed by Spanish Superior Scientific Research Council (CSIC) together with Gregorio Maranon Hospital in Madrid and Clinic Hospital in Barcelona, reveals MVA-B preventive vaccine's immune efficiency against Human's immunodeficiency virus (HIV)....]]> http://www.medindia.net/news/Promising-Show-By-HIV-Vaccine-MVA-B-In-Clinical-Trials-91233-1.htm http://www.medindia.net/news/Prior-Insider-Information-from-Cancer-Clinical-Trials-Impacts-Drug-Companys-Stock-Prices-91209-1.htm 'Insider trading' that gives prior knowledge of phase III clinical trials of new drugs and Food and Drug Administration (FDA) regulatory decisions may push up or pull down the price of a drug company's stock, suggests a study published September 26 in the iJournal of the National Cancer Institute/i. Regulatory decisions made by the FDA and phase III clinical trials are important for the financial success of new drugs. Investors with information on the trial results and FDA decisions before ...]]> http://www.medindia.net/news/Prior-Insider-Information-from-Cancer-Clinical-Trials-Impacts-Drug-Companys-Stock-Prices-91209-1.htm http://www.medindia.net/news/How-to-Prevent-a-Second-Stroke-Answers-from-Stroke-Prevention-Clinical-Trial-90270-1.htm A large nationwide clinical trial showed patients at a high risk for a second stroke who received intensive medical treatment had fewer strokes and deaths than patients who received a brain stent plus the medical treatment. The investigators published the results in the online first edition of the INew England Journal of Medicine/I. The National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, funded the trial. The medical regimen included ...]]> http://www.medindia.net/news/How-to-Prevent-a-Second-Stroke-Answers-from-Stroke-Prevention-Clinical-Trial-90270-1.htm http://www.medindia.net/news/Clinical-Trials-of-Organ-Care-System-Successfully-Maintains-a-Beating-Heart-for-Transplant-Delivery-90216-1.htm Recent clinical trials conducted on the Organ Care System developed by Transmedics gives hope of delivering a still-beating heart to a transplant patient. This device is currently undergoing phase II clinical trials. Once the heart is removed from the donor's body, it is placed in this OCS device. Soon the heart is revived to a beating state and is maintained at the appropriate temperature. Heart monitors are also provided to evaluate the functioning of the heart during the transport phase....]]> http://www.medindia.net/news/Clinical-Trials-of-Organ-Care-System-Successfully-Maintains-a-Beating-Heart-for-Transplant-Delivery-90216-1.htm http://www.medindia.net/news/Report-Public-Disclosure-of-Clinical-Trial-Results-by-Health-Canada-Should-be-Mandatory-90006-1.htm An analysis in CMAJ (Canadian Medical Association Journal) says that Health Canada is not prevented by law from publicly disclosing safety and efficacy data from clinical trials, pharmaceuticals, biologics and medical devices and should be more transparent. An example of the need for transparency relates to antidepressants known as selective serotonin reuptake inhibitors (SSRIs). These were not authorized for sale to people under the age of 19 because of risks of self-harm associated with SSRIs in that age group....]]> http://www.medindia.net/news/Report-Public-Disclosure-of-Clinical-Trial-Results-by-Health-Canada-Should-be-Mandatory-90006-1.htm http://www.medindia.net/news/Anti-Psychotic-Drug-Trial-On-Teens-Abandoned-In-Australia-89438-1.htm An anti-psychotic drug trial on teenagers has been given up in Australia, following strong protests from the international scientific community, reports say. The controversy revolves around Quetiapine, sold as Seroquel and manufactured by AstraZeneca. They were to fund the trial. Experts were concerned children who had not yet been diagnosed with a psychotic illness would be unnecessarily given drugs with potentially dangerous side effects. Anti-psychotics are vital, but should not be used without ...]]> http://www.medindia.net/news/Anti-Psychotic-Drug-Trial-On-Teens-Abandoned-In-Australia-89438-1.htm http://www.medindia.net/news/Long-delayed-Pfizer-Payouts-Over-Nigerian-Drug-Trial-Begins-89054-1.htm US pharmaceutical giant Pfizer on Thursday began long-awaited compensation payments to families over a 1996 drug trial blamed for the deaths of 11 children and disabilities in dozens of others. But even as the compensation process began, the company faced further criticism since only four families were paid in the initial disbursements, while some 200 children participated in the trial of meningitis drug Trovan. Parents of four of the children who died received cheques of (Dollor) 175,000 each at ...]]> http://www.medindia.net/news/Long-delayed-Pfizer-Payouts-Over-Nigerian-Drug-Trial-Begins-89054-1.htm http://www.medindia.net/news/New-Alzheimers-Drug-Might-be-Ready-for-Clinical-Trials-Soon-88983-1.htm Scientists working on finding a cure for Alzheimer's disease revealed that they could start testing for the drug in the next six years. A team of international scientists have been working on the research that has cost over 14.6 million euro and a drug to cure the disease could be possible in the near future with the researchers stating that they could stop the disease by blocking the protein plaques that cause Alzheimer's. The researchers said that Alzheimer's can now be detected early even before ...]]> http://www.medindia.net/news/New-Alzheimers-Drug-Might-be-Ready-for-Clinical-Trials-Soon-88983-1.htm http://www.medindia.net/news/Clinical-Trials-Now-for-Gene-Therapy-to-Reverse-Heart-Failure-88027-1.htm After years of proving itself highly effective in the lab and a large animal study a promising gene therapy to prevent and reverse congestive heart failure is ready for clinical trials now. The therapy was developed, in part, at a href="http:www.jefferson.edu"Thomas Jefferson University's/a a href="http:www.jefferson.edu/jmc/medicine/translational_medicine/"Center for Translational Medicine/a. Reporting in the online July 20 issue of iScience Translational Medicine/i, cardiology ...]]> http://www.medindia.net/news/Clinical-Trials-Now-for-Gene-Therapy-to-Reverse-Heart-Failure-88027-1.htm http://www.medindia.net/news/Existence-of-trial-Effect-in-HIV-Clinical-Trials-Confirmed-87751-1.htm A recent study confirms the existence of a "trial effect" in the clinical trials for treatment of HIV. Trial effect is an umbrella term for the benefit experienced by study participants simply by virtue of their participating in the trial. It includes the benefit of newer and more effective treatments, the way those treatments are delivered, increased care and follow-up, and the patient's own behavior change as a result of being under observation. "Trial effect is notoriously difficult ...]]> http://www.medindia.net/news/Existence-of-trial-Effect-in-HIV-Clinical-Trials-Confirmed-87751-1.htm http://www.medindia.net/news/Clinical-Trial-Result-Widens-Pool-of-Donors-for-Leukemia-and-Lymphoma-Patients-87493-1.htm Results of two clinical trials have made it easier to identify a suitable donor for leukemia and lymphoma patients who need bone marrow transplants. According to researchers transplant results with half-matched bone marrow or umbilical cord blood are comparable to fully matched tissue, thanks in large part to the availability of effective antirejection drugs and special post-transplant chemotherapy. The finding means that nearly all patients in need of a transplant can find donors, according ...]]> http://www.medindia.net/news/Clinical-Trial-Result-Widens-Pool-of-Donors-for-Leukemia-and-Lymphoma-Patients-87493-1.htm