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Serum Bactericidal Test
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| Test |
Serum Bactericidal Test |
| Indication |
Determine the maximum bactericidal dilution or serum bactericidal dilution of serum or body fluid after administration of antibiotics.
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| Physiology |
The serum bactericidal test has been applied experimentally to detect antimicrobial activity in cerbrospinal fluid, join fluid, and amniotic fluid. It is useful in determining whether serum antimicrobial activity remains adequate after a shift from parenteral to oral therapy. Serum bactericidal titers are useful in evaluating synergy between antibiotics after administration of the drugs.
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| Normal Range |
Peak bactericidal activity should be observed at >1:8 dilution, trough at >1:2.
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| Interpretation |
The titer is useful in monitoring total therapeutic effect. It is used to evaluate therapy in endocarditis, osteomyelitis, and suppurative arthritis. Serum bactericidal titers of >1:8 are often recommended for the optimal treatment of these infections.
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| Sample |
Peak and trough serum from patient and bacterial isolate causing infection.
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| Test Method |
Serial dilution of patients serum with Mueller Hinton broth.
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| Related Tests |
Antibiotic level
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