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Tartarate Resistant Leukocyte Acid Phosphatase/ Acid phosphatase/ Leukocyte Acid Phosphatase. |
| Test |
Tartarate Resistant Leukocyte Acid Phosphatase/ Acid phosphatase/ Leukocyte Acid Phosphatase. |
| Indication |
This test is used to diagnose "hairy cell leukemia"/ "Leukemic reticuloendotheliosis"
|
| Physiology |
There are six isoenzymes of leukocyte acid phosphatase. Isoenzyme V is not inhibited by L (+) tartaric acid. Malignant nuclear cells of leukemic reticuloendotheliosis contain isoenzyme V and are resistant to inhibition by L (+) tartaric acid. |
| Normal Range |
Most white cells of peripheral blood as well as platelets are acid phosphatase positive. |
| Test Method |
Naphthol AS-BI, fast garnet GBC, with and without L(+) tartaric acid. |
| Related Tests |
Leukocyte Cytochemistry, Lymph node biopsy |
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