The test is used to detect Vitamin B12 deficiency as in pernicious anemia in those patients who have hematologic symptoms – weakness, anemia, hyper-segmented neutrophils, leucopenia, or Neurologic – numbness, tingling, loss of vibratory sensation.
Physiology
Cyanocobalamin analogues from the base compound in coenzymes having important biologic functions. Vitamin B12 is not synthesized by humans. It is a requisite dietary component widely available in animal products. The minimum daily requirement is 1-5 µg/day, body stores are 2000-5000 µg. Vitamin B12 is absorbed by microvilli of the ileum a pH and divalent cation dependent process.
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