Biochemistry Test

Creatinine kinase

Dr. Krishanga
Medically Reviewed by Dr. Krishanga, BDS
Last Updated on Feb 16, 2024
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Test : Creatinine kinase


Indications :

A Creatine kinase (CK) test is used to diagnose the below diseases (1 Trusted Source
Creatine Kinase

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)

  • Muscular dystrophy: It causes weakness, breakdown, and loss of skeletal muscle functions.
  • Rhabdomyolis: A rapid breakdown of muscle tissues caused by serious injury, muscle disease, or other diseases.
  • Heart attack
  • Heart damages

A creatine kinase (CK) test may be ordered if you have the below symptoms of muscular disorder (2 Trusted Source
About Creatine Kinase (CK)

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)

  • Muscle weakness
  • Balance issues
  • Numbness or tingling
  • Muscle pain or cramps
  • Dark urine


Physiology :

Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme That is present in the heart, skeletal muscle, and a small amount in the brain. When the cells in the skeletal muscles, heart muscles, or brain are damaged, they release CK into the blood. (2 Trusted Source
About Creatine Kinase (CK)

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)

There are three types of CK enzymes:

  • CK-MM – Found mostly in skeletal muscles
  • CK-MB – Found mostly in heart muscle
  • CK-BB – Found mostly in brain tissue


Normal Range :

The reference range of CK is 22-334 IU/L for men and 22-199 IU/L for women. It may vary from laboratory to laboratory. (3 Trusted Source
Creatine kinase in the U.S. population

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)



Interpretation :

Based on the types of CK enzymes, the test results indicate the below results: (1 Trusted Source
Creatine Kinase

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)

  • Higher than normal CK-MM enzymes: It may mean you have muscular dystrophy or rhabdomyolis
  • Higher than normal CK-MB enzymes: It may mean you have heart muscle inflammation or are having a heart attack
  • Higher than normal CK-BB enzymes: It may mean you have had a stroke or brain injury

Other conditions which causes higher CK level may include, (1 Trusted Source
Creatine Kinase

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)

  • Blood clots
  • Prolonged surgery
  • Hormonal disorders
  • Certain medications
  • Infections
  • Strenuous exercise
  • Seizures
  • Connective tissue disorders
  • Kidney failure
  • Celiac disease
  • Shot injections


References:

  1. Creatine Kinase - (https://medlineplus.gov/lab-tests/creatine-kinase/)
  2. About Creatine Kinase (CK) - (https://my.clevelandclinic.org/health/diagnostics/22692-creatine-kinase-ck)
  3. Creatine kinase in the U.S. population - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370787/)
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sandeep199118, India

TEST RATE OF CPK

ramesh7074, India

"My mother aged 75 has her report as follows, esr count is 70mm/ist hour blood urea 21mg/dl,serum creatinine-9mg/dl, albumin creatinine ratio 181.8 mg/dl"

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