| Treatment |
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Once
prostate cancer has been diagnosed, graded, and staged,
there is a lot to consider before you choose a treatment
plan. The treatment you choose for prostate cancer should
also take into account your age and expected life span,
personal preferences and feelings about the side effects
associated with each treatment, any other serious health
conditions you have, and the stage and grade of your
cancer.
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| Surgery |
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The
two most common prostate operations are radical
prostatectomy and transurethral resection of the prostate.
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| Radical
prostatectomy |
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This
procedure removes the entire prostate gland plus some
tissue around it. Radical prostatectomy is used most often
if the cancer is thought not to have spread outside of the
gland. The patient is generally put under general
anaesthesia or under spinal or epidural anesthesia during
the surgery.
There are two main types of radical prostatectomy radical
retropubic prostatectomy and radical perineal
prostatectomy. In the retropubic operation, the surgeon
makes a skin incision in the lower abdomen. The surgeon
can remove lymph nodes during this operation through the
same incision.
A nerve-sparing radical retropubic prostatectomy is a
modification of this operation. During this procedure, the
surgeon carefully fells the small bundles of nerves on
either side of the prostate gland. If the cancer has not
spread to these nerves, the surgeon will not remove them.
Because these are the nerves that are needed for
erections, leaving them intact lowers the risk of
impotence following surgery.
The radical perineal prostatectomy removes the prostate
through an incision in the skin between the scrotum and
anus.
These operations last from one to four hours. This is
followed by an average hospital stay of three days and
average time away from work of three to five weeks. In
most cases, you will be able to donate your own blood
before surgery. This blood can be given back to you during
the operation, if needed.
For most patients, a catheter is inserted through the
penis and into the bladder after surgery while the patient
is still asleep. The catheter stays in place for 10 to 21
days and allows you to urinate easily while you are
healing. You will be able to urinate on your own after the
catheter is removed.
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| Transurethral
resection of the prostate |
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This
operation removes part of the prostate gland that
surrounds the urethra. It is most often used to treat men
with non-cancerous enlargement of the prostate called
benign prostatic hyperplasia. The procedure is also used
for men with prostate cancer who cannot have a radical
prostatectomy because of advanced age or a serious illness
in addition to their prostate cancer. It can be used to
relieve symptoms caused by a cancer before other
treatments begin. But it is not expected to cure this
disease or remove all of the cancer.
A
tool with a small loop of wire on the end is placed inside
the prostate through the urethra. Electricity is passed
through the wire to heat it and cut the tissue. Either
spinal anaesthesia or general anaesthesia is used. The
operation usually takes about one hour.
A
catheter is inserted through the penis into the bladder
after surgery. It remains in place for two or three days
to help urine drain while the prostate heals. You can
usually leave the hospital after one to two days and
return to work in a week or two. There may be some
bleeding into the urine after surgery anaesthesia used.
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| Cryosurgery |
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Cryosurgery,
also called cryotherapy or cryoablation, is used to treat
localized prostate cancer by freezing its cells with a
metal probe.
Warm saline water is circulated through a
catheter in the urethra to keep it from freezing. The
probe is placed through a skin incision located between
the anus and scrotum, and guided into the cancer using
transrectal ultrasound. The appearance of prostate tissue
in ultrasound images changes when it is frozen. Spinal or
epidural anaesthesia is used during the procedure.
The
catheter is removed on to two weeks later. After the
procedure, there will be some bruising and soreness of the
area where the probe was inserted. Men usually remain in
the hospital for one or two days.
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| Radiation
therapy |
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Radiation
therapy uses high-energy rays (such as gamma rays or
x-rays) and particles (such as electrons, protons, or
neutrons) to kill cancer cells. Radiation is sometimes
used to treat cancer that is still confined within the
prostate gland, or has spread to nearby tissue. If the
disease is more advanced, radiation may be used to reduce
the size of the tumour and to provide relief from present
and future symptoms. Radiation usually eliminates the need
for surgery. Patients who do not have a good response with
radiation therapy may still have surgery at a later date.
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| Hormone
therapy |
|
In
the early 1940s two doctors, Huggins and Hodges, won the
Nobel Prize for Medicine for their discovery that most
prostate cancer cells are dependent on the male hormone
testosterone for nourishment.
Combination
hormone therapy (CHT) means the use of two drugs to
control the bodies production of testosterone. It is the
most widely used of several variations of hormone therapy.
CHT combines the drugs to reduce or eliminate or block the
effects of the production of testosterone from the
testicles and adrenal glands.
Testosterone
is produced primarily by the testes (testicles), and in
much lesser amounts by the adrenal glands. A combination
of drugs is used to (a) prevent production of testosterone
by the testicles and (b) block the cancer tumour from
using the testosterone can cause a substantial reduction
in the total body tumor mass of cancer in about 80 per
cent of cases.
This
treatment is often used of patients whose prostate cancer
has spread to other parts of the body or has come back
after treatment. Most evidence shows that hormone therapy
works better if it is started as early as possible after
the cancer has reached an advanced stage. The goal of
hormone therapy is to lower levels of the male hormones,
androgens.
Androgens
are produced mainly in the testicles and cause prostate
cancer cells to grow. Lowering androgen levels can make
prostate cancers shrink or grow more slowly. But hormone
therapy does not cure the cancer.
Until
recently CHT was used primarily as a treatment of symptoms
in late stage prostate cancer when it had spread outside
the prostate capsule to surrounding tissue or the ones.
However, evidence is accumulating that CHT may deserve a
larger role in the management of prostate cancer.
CHT
is increasingly being recommended for a few months prior
to other procedures such as radical prostatectomy. Leading
urologists, however, disagree on its use.
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| Chemotherapy |
|
This
is used for patients whose prostate cancer has spread
outside of the prostate gland and for whom hormone therapy
has failed. It is not expected to destroy all the cancer
cells, but it may slow tumour growth and reduce pain.
Chemotherapy is not recommended as a treatment for men
with early prostate cancer.
Chemotherapy
uses anti-cancer drugs that are injected into a vein,
injected into a muscle, or taken orally. These drug skill
cancer cells, but they also damage some normal cells.
Sometimes, hospitalization may be needed to monitor the
treatment and to control its side effect.
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| Watchful
waiting |
|
It
is generally agreed that prostate cancer is a progressive,
but slow-growing disease. It usually takes many years to
determine with confidence whether prostate cancer has been
cured by aggressive treatment. Therefore, following
treatment patients are monitored with periodic checkups
and PSA tests for progression of the disease. These
periods between aggressive treatments are known as
watchful waiting. Watchful waiting allows the patient and
his doctor to watch for progression and make decisions
about more aggressive treatment if need for such
treatments is indicated by a PSA that rises too rapidly or
symptoms appear.
Most
men with prostate cancer die of other causes before they
ever experience symptoms of the disease.
Recent
studies indicate that patients of prostate cancer may do
about as well in terms of survival by choosing watchful
waiting instead of radical prostatectomy, or external beam
radiation, the standard treatments. So a question has been
raised as to when or if aggressive treatment is necessary.
Watchful waiting is gaining acknowledgment as a viable
first line treatment in some cases of prostate cancer,
particularly when the Gleason Score is low or the patient
is elderly or in otherwise poor health.
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| Diet
and prostate cancer |
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Whether
or not diet can help in the prevention or cure of prostate
cancer is a very difficult question to answer. In term as
of prevention, the answer may be yes, but there is very
little hard scientific evidence to e more certain.
However, a lack of scientific evidence does not
necessarily mean a lack of benefit, but simply that very
little research ahs been performed in this area. There is
a great deal anecdotal evidence which points to diet as
benign a major factor in accelerating the disease.
Vegetarians
are approximately half as likely to develop prostate
cancer as meat eaters. It is not clear why this should be
the case. It is not clear whether meat itself is the
problem or whether a person who eats more meat is less
likely to eat other beneficial foods for example.
It
is observed that people in eastern countries such as
India, China and Japan are far less likely than westerners
to develop cancer. Also, the levels of cancer in the east
are arising and this coincides with changes in lifestyle
since more people are eating western style foods.
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