It has various types which are classified based on the type of mechanism
Antibody mediated Cell mediated Injury
Injury to glomeruli results in a variety of signs and symptoms of disease including:
Proteinurias | caused by | altered permeability of capillary walls. | Hematuria | caused by
| loss of capillary wall integrity.
| Azotemia | caused by |
impaired filtration of nitrogenous wastes. |
Oliguria oranuria |
caused by |
reduced or absent urine production. | Edema | caused by | loss of intravascular oncotic pressure.
| Hypertension | caused by | fluid retentionand altered renal regulation of blood pressure. |
Several syndromes related to glomerulonephritis have been described.
Nephrotic syndrome: Proteinuria in excess of 3.5 grams in 24 hours, accompanied by edema, hypoalbuminemia, hyperlipidemia and lipiduria.
Acute nephritis or the Nephritic syndrome: Hematuria, variable proteinuria, azotemia, and hypertension.
Rapidly progressive glomerulonephritis: Hematuria, oliguria and acute renal failure.
Although much overlap exists, glomerular diseases may be classified by their predominant clinical manifestations.
| Nephroti Syndrome | Nephritic Syndrome | | Minimal change disease | +++++ | - | | Membranous glomerulonephritis | ++++ | + | | Focal segmental glomerulosclerosis |
++++ | + | | IgA nephropathy | +++ | ++ | | Membranoproliferative GN | ++ | +++ | | Acute post-infectious GN | + | ++++ |
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