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Risks of Complications are Higher in ART Than in Natural Conception
July 27, 2007 at 5:26 PM
General Health News
Dr Alastair Sutcliffe, Institute of Child Health, University College London, UK and Dr Michael Ludwig, Endokrinologikum, Hamburg, Germany reviewed data published between 1980 and 2005 on in-vitro fertilisation (IVF) and intracytoplasmic sperm injection, and used 3980 articles to compile their analysis. They focussed mainly on ART single births, since multiple births bring with them their own set of confounding complications.
The authors say: “In-vitro fertilisation has been done for nearly 30 years; in developed countries at least 1% of births are from ARTs. These children now represent a substantial portion of the population but little is known about their health."
They say that there are several points for consideration when counselling couples seeking treatment for subfertility. The biggest risk for ART is that multiple births may occur, however a number of other risks are evident from ART techniques.
Spontaneous abortion rates are between 20-34% higher for ART couples compared to those spontaneously conceiving -- this could be because ART couples are generally older, and also due to endocrine disorders, organic abnormalities and the degree of ovarian stimulation. For couples using ART, the risk of pre-eclampsia occurring is increased by 55%, while there is also an increased risk of still birth (155%), low birthweight (70-77%) very low birthweight (170-200%), or the baby being small for gestational age (40-60% increased risk).
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