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Gene Variants for Crohn's Disease Identified
The study has reinforced earlier results of a German study that identified the same gene variant associated with the adult form of the disease.Crohn’s disease is a chronic and painful condition attributed to inflammation of the gastrointestinal tract.
“Because Crohn’s disease is complex, with multiple genes interacting with each other and with environmental factors, it’s important to sort out specific genes and to replicate previous findings,” said the study’s first author, Robert N. Baldassano, M.D., director of the Center for Pediatric Inflammatory Bowel Disease at Children’s Hospital.
“There are different types of Crohn’s disease, so classifying types by genetic profiles may help us select the most appropriate treatments for each patient,” he added.
The study compared the genomes of 143 children with Crohn’s disease to genomes of 282 matched control subjects. The study team found that 64 percent of children with Crohn’s disease had a specific variant form of the gene ATG16L1, compared with 52 percent of the healthy children.
The odds ratio for children with the gene variant was 1.62 compared to control children, meaning that those who have the variant were 62 percent more likely to have Crohn’s disease than children with the more common allele.
A separate test that analyzed trios (a Crohn’s patient and both parents) also found an association between the ATG16L1 gene variant and disease symptoms. This finding strengthened the results of the pediatric case-control study.
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