Keeping in mind the importance of preventing astronauts from harmful effects of space radiation during extended missions to the Moon or Mars, scientists have shown that radiation targets stem cells in the hippocampus, a brain area important for learning and mood control.
The new findings are based on a study of mice conducted by researchers from the Cold Spring Harbor Laboratory, Brookhaven National Laboratory, NASA’s Kennedy Space Center and the McKnight Brain Institute of the University of Florida.
According to the researchers, identifying medications or physical shielding to protect astronauts from cosmic and solar radiation will be important for the success of human space missions beyond low Earth orbit.
“Our discovery does not present any adverse issues for the astronaut program because the ground-based dose and application of radiation we used were not comparable to that seen for existing space travel,” said Dr. Dennis A. Steindler, executive director of UF’s McKnight Brain Institute, a professor of neuroscience at the UF College of Medicine and co-investigator in the study.
“But the exceptional sensitivity of these neural stem cells suggests that we are going to have to rethink our understanding of stem cell susceptibility to radiation, including cosmic radiation encountered during space travel, as well as radiation doses that accompany different medical procedures,” he added.
During the course of study, Cold Spring Harbor Laboratory scientists developed mice that were genetically engineered with easily identifiable, fluorescent stem cells. The stem cells lose their fluorescence when they transform into neurons, which makes it easier to account for them.